Poly-(d,l-Lactic Acid) Microspheres Incorporating Histological Dyes for Intra-pulmonary Histopathological Investigations

Armstrong, David J.; Elliott, Paul I. P.; Ford, J. L.; Gadsdon, D; Mccarthy, G. P.; Rostron, C.; Worsley, M. D.

doi:10.1111/j.2042-7158.1996.tb05913.x

Cited by 21 publications

(9 citation statements)

References 11 publications

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“…Synthetic polymers are much more frequently used than natural polymers. Even if the synthetic polymers are well tolerated as implants, they are not biologically inert when they are not biologically inert when they are used as particles (Armstrong et al 1996). In fact, particles having sizes ranging from nanometers to micrometers can be internalized by macrophages and then degraded inside the cells, leading to a possible toxicity.…”

Section: Significance Of Nanotechnology By Pulmonary Routementioning

confidence: 99%

From Fluorescence Nanoscopy to Nanoscopic Medicine

Peters

2008

Nanomedicine

117

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The purpose of this review is to discuss the impact of nanocarriers administered by pulmonary route to treat and to diagnose respiratory and non respiratory diseases. Indeed, during the past 10 years, the removal of chlorofluorocarbon propellants from industrial and household products intended for the pulmonary route has lead to the developments of new alternative products. Amongst these ones, on one hand, a lot of attention has been focused to improve the bioavailability of marketed drugs intended for respiratory diseases and to develop new concepts for pulmonary administration of drugs and, on the other hand, to use the pulmonary route to administer drugs for systemic diseases. This has led to some marketed products through the last decade. Although the introduction of nanotechnology permitted to step over numerous problems and to improve the bioavailability of drugs, there are, however, unresolved delivery problems to be still addressed. These scientific and industrial innovations and challenges are discussed along this review together with an analysis of the current situation concerning the industrial developments.

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Section: Significance Of Nanotechnology By Pulmonary Routementioning

confidence: 99%

From Fluorescence Nanoscopy to Nanoscopic Medicine

Peters

2008

Nanomedicine

117

View full text Add to dashboard Cite

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“…Because of the above characteristics, lipid particles overcome most of the drawbacks associated with polymeric particles, such as inefficient biodegradation, polymer accumulation effects, toxicity and the general requirement of organic solvents for their production [1,3,[15][16][17], and therefore represent an alternative carrier system to traditional polymeric microparticles and nanoparticles.…”

Section: Introductionmentioning

confidence: 99%