Poly(dopamine)-inspired surface functionalization of polypropylene tissue mesh for prevention of intra-peritoneal adhesion formation

Lu, Sheng; Ma, Ying; Ren, Pengfei; Ma, Xiaoe; Zhou, Naizhen; Hu, Wanjun; Ji, Zhenling

doi:10.1039/c6tb02667b

“…Additionally, the plasma treatment parameters used here are similar to those of plasmas applied towards surface modification of biomaterials currently used clinically, or being investigated for such use. Power outputs between 40 W and 200 W, treatment durations between 30 s and 10 min, and carrier gases such as Ar, N 2 , O 2 , and NH 3 have been reported for plasma treatments of surgical meshes (Hu et al, 2017;Lanzalaco et al, 2019;Nisticò et al, 2015;Rivolo et al, 2016;Sanbhal et al, 2019Sanbhal et al, , 2018bSannino et al, 2005;Zhang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Nonthermal plasma treatment of polymers modulates biological fouling but can cause material embrittlement

Learn

¹

,

Lai

²

,

Wilson

³

et al. 2021

Journal of the Mechanical Behavior of Biomedical Materials

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Plasma-based treatment is a prevalent strategy to alter biological response and enhance biomaterial coating quality at the surfaces of biomedical devices and implants, especially polymeric materials. Plasma, an ionized gas, is often thought to have negligible effects on the bulk properties of prosthetic substrates given that it alters the surface chemistry on only the outermost few nanometers of material. However, no studies to date have systematically explored the effects of plasma exposure on both the surface and bulk properties of a biomaterial. This work examines the time-dependent effects of a nonthermal plasma on the surface and bulk properties of polymeric implants, specifically polypropylene surgical meshes and sutures. Findings suggest that plasma exposure improved resistance to fibrinogen adsorption and Escherichia coli attachment, and promoted mammalian fibroblast attachment, although increased duration of exposure resulted in a state of diminishing returns. At the same time, it was observed that plasma exposure can be detrimental to the material properties of individual filaments (i.e. sutures), as well as the structural characteristics of knitted meshes, with longer exposures resulting in further embrittlement and larger changes in anisotropic qualities. Though there are few guidelines regarding appropriate mechanical properties of surgical textiles, the results from this investigation imply that there are ultimate exposure limits for plasma-based treatments of polymeric implant materials when structural properties must be preserved, and that the effects of a plasma on a given biomaterial should be examined carefully before translation to a clinical scenario.

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“…Additionally, plasma can easily treat objects with complex geometries and high surface areas. Numerous studies have therefore explored plasma surface treatments for surgical meshes (Avetta et al, 2014;Binnebösel et al, 2012Binnebösel et al, , 2010Gorgieva et al, 2015;Hu et al, 2017;Junge et al, 2007;Kulaga et al, 2014;Kumar et al, 2013;Labay et al, 2015;Lanzalaco et al, 2019;Lu et al, 2019;Nisticò et al, 2017Nisticò et al, , 2015Nisticò et al, , 2013Nisticò et al, , 2012Paul et al, 2010;Rivolo et al, 2016;Sanbhal et al, 2019Sanbhal et al, , 2018bSannino et al, 2005;Zhang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Nonthermal plasma treatment of polymers modulates biological fouling but can cause material embrittlement

Learn

¹

,

Lai

²

,

Wilson

³

et al. 2019

Preprint

4

3

0

View full text Add to dashboard Cite

Plasma-based treatment is a prevalent strategy to alter biological response and enhance biomaterial coating quality at the surfaces of biomedical devices and implants, especially polymeric materials. Plasma, an ionized gas, is often thought to have negligible effects on the bulk properties of prosthetic substrates given that it alters the surface chemistry on only the outermost few nanometers of material. However, no studies to date have systematically explored the effects of plasma exposure on both the surface and bulk properties of a biomaterial. This work examines the time-dependent effects of a nonthermal plasma on the surface and bulk properties of polymeric implants, specifically polypropylene surgical meshes and sutures. Findings suggest that plasma exposure improved resistance to fibrinogen adsorption and Escherichia coli attachment, and promoted mammalian fibroblast attachment, although increased duration of exposure resulted in a state of diminishing returns. At the same time, it was observed that plasma exposure can be detrimental to the material properties of individual filaments (i.e. sutures), as well as the structural characteristics of knitted meshes, with longer exposures resulting in further embrittlement and larger changes in anisotropic qualities. Though there are few guidelines regarding appropriate mechanical properties of surgical textiles, the results from this investigation imply that there are ultimate exposure limits for plasma-based treatments of polymeric implant materials when structural properties must be preserved, and that the effects of a plasma on a given biomaterial should be examined carefully before translation to a clinical scenario.

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“…The poly(DOPA) layer on inorganic scaffold could effectively activate the inert CCPP scaffold and concatenate multiple functional groups on the surface; however, it may be problematic for cell attachment and migration. 32 Therefore, for the ultimate coverage of the collagen coating, its secondary modification was necessary to promote biocompatibility. Covering with collagen layers resulted in an apparent change in the particulate and porous microstructure to a much denser and smoother surface (although the scaffolds' porous surface was completely covered by collagen to form a smooth surface, the collagen layer was easy to degrade and was then dedicated to promoting cell attachment and migration).…”

Section: Resultsmentioning

confidence: 99%

Introducing copper and collagen (viapoly(DOPA)) coating to activate inert ceramic scaffolds for excellent angiogenic and osteogenic capacity

Wang

¹

,

Wu

²

,

Qi

³

et al. 2018

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Poly(dopamine)-inspired surface functionalization of polypropylene tissue mesh for prevention of intra-peritoneal adhesion formation

Abstract: The poly(dopamine)-inspired coating of O2 plasma treated PP mesh with chitosan shows an excellent anti-adhesion property.

Cited by 41 publications

References 36 publications

Nonthermal plasma treatment of polymers modulates biological fouling but can cause material embrittlement

Nonthermal plasma treatment of polymers modulates biological fouling but can cause material embrittlement

Nonthermal plasma treatment of polymers modulates biological fouling but can cause material embrittlement

Introducing copper and collagen (viapoly(DOPA)) coating to activate inert ceramic scaffolds for excellent angiogenic and osteogenic capacity

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