Poly (Ethylene Glycol) Methyl Ether Methacrylate-Based Hydrogel and Cerium(IV) Oxide Nanoparticles as Ophthalmic Lens Material

Abstract

The functional hydrogel lens containing 2-hydroxyethylmethacrylate (HEMA) was manufactured by thermal polymerization. The physical properties of the produced hydrogel lens were measured and analyzed. In this study, HEMA, ethylene glycol dimethacrylate (EGDMA), and azobisisobutyronitrile (AIBN) were used for thermal copolymerization. Additionally, poly (ethylene glycol) methyl ether methacrylate (PEGMEMA), 3-(Triethoxysilyl) propyl isocyanate (TEPI), and cerium(Ⅳ) oxide nanoparticles were used as additives to make a functional hydrogel lens. The mixture was heated at 100 °C for 90 min to produce the hydrogel ophthalmic lens by the cast mold method. The resulting physical properties showed that the water content and refractive index of the sample were in the ranges of 38.06~42.11% and 1.426~1.436, respectively. The addition of cerium oxide nanoparticles lowered the contact angle and allowed the hydrogel lens to block UV light. The tensile strength was also improved by 52.13% through cerium oxide nanoparticles, and up to 123.4% by using TEPI. Based on the results of this study, the produced ophthalmic lens is suitable for durable, UV-blocking high-performance lenses.

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

“…In particular, micelles constructed of amphiphilic block polymers such as PEGMA have been widely studied in drug administration with the goal of tumor‐targeted theranostics. [ 23–35 ] Polymeric nanocomposites containing zinc oxide can help prepare biocompatible nanoparticles and effectively deliver chemotherapy drugs to cancer cells. Many studies have shown that Zinc oxide nanoparticles can be used to provide chemotherapy agents as a cancer treatment.…”

“…In particular, micelles constructed of amphiphilic block polymers such as PEGMA have been widely studied in drug administration with the goal of tumor-targeted theranostics. [23][24][25][26][27][28][29][30][31][32][33][34][35] Polymeric nanocomposites containing zinc oxide can help prepare biocompatible nanoparticles and effectively deliver chemotherapy drugs to cancer cells.…”

Surface Self-Assembly Construction of Therapeutic Contact Lens with Bacterial “Kill-Releasing” and Drug-Reloading Capabilities for Efficient Bacterial Keratitis Treatment

“…Contact lenses, originally used for vision correction, recently have been adopted for ocular delivery of antimicrobial agents to treat infectious keratitis due to extended corneal contact, drug retention time in ocular surface, improved corneal permeation, and biosafety. , In particular, various drug delivery strategies have been extensively applied in contact lenses (CLs), including soaking, molecular imprinting, embedding, and surface coating. − For example, Liu et al prepared a multilayer-silver nanoparticle (AgNP)-loaded contact lens through a mussel-inspired facile method for early treatment of bacterial keratitis . However, poor biosafety and biocompatibility caused by the release of metal ions may restrict their applications .…”