Poly(Ethylene Glycol)/β-Cyclodextrin Pseudorotaxane Complexes as Sustainable Dispersing and Retarding Materials in a Cement-Based Mortar

Capacchione, Clotilde; Sala, Paolo Della; Quaratesi, Ilaria; Bruno, Immacolata; Pauciulo, Antonio; Bartiromo, Andrea Roberta; Iannece, Patrizia; Neri, Placido; Talotta, Carmen; Gliubizzi, Rocco; Gaeta, Carmine

doi:10.1021/acsomega.1c01133

Cited by 7 publications

(2 citation statements)

References 41 publications

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“…The TGA graph of the PNCDHA polymer ( Figure 4 ) demonstrated three phases of degradation that indicated three components in the PNCDHA polymer. The first, around 90–100 °C, resulted from the evaporation of water from the surface of the polymer [ 34 , 35 ]. The second, at 200–230 °C, accompanied by a weight loss of 38.5%, may possibly be a consequence of the partial degradation of HA [ 36 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

The Dual Modification of PNIPAM and β-Cyclodextrin Grafted on Hyaluronic Acid as Self-Assembled Nanogel for Curcumin Delivery

et al. 2022

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Curcumin is an extract of turmeric (Curcuma longa) which possesses anti-inflammatory, anti-cancer and wound-healing effects and has been used as an active compound in biomedical research for many years. However, its poor solubility presents challenges for its use in drug delivery systems. A modified nanogel delivery system, with PNIPAM and β-cyclodextrin grafted onto hyaluronic acid (PNCDHA), was utilized to enhance the solubility. The polymer was characterized by NMR, and the inclusion complex between curcumin and β-cyclodextrin was confirmed by FTIR. The potential of this PNCDHA polymer complex as a drug delivery vehicle was supported by a curcumin encapsulation efficiency of 93.14 ± 5.6% and the release of encapsulated curcumin at 37 °C. At a concentration of 0.5% w/v in water, PNCDHA nanogels were biocompatible with fibroblast cell line (L929) up to a curcumin concentration of 50 µM. There was a direct concentration between curcumin loading and cellular internalization. A more detailed study of the cellular internalization of PNCDHA nanogel should be considered in order to clarify cellular delivery mechanisms and to assess how its viability as a carrier may be optimized.

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Section: Resultsmentioning

confidence: 99%

The Dual Modification of PNIPAM and β-Cyclodextrin Grafted on Hyaluronic Acid as Self-Assembled Nanogel for Curcumin Delivery

et al. 2022

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“…Similar trends were also noted for the PEG 10 PCL y series (SI, Figure S10), indicating that even prior to lyophilization/reconstitution, the addition of β-CD promoted significant aggregation and morphological changes in the micelles when the PEG M n was >2 kDa. This behavior may be related to the formation of pseudo-rotaxanes between the β-CD and the PEG corona of the micelles, with subsequent hydrogen-bonding between the β-CD leading to aggregation of the micelles [46][47][48][49]. β-CD is also known to form inclusion complexes with PCL, which may also contribute to the disruption of the micelle morphology [50][51][52][53].…”

Section: Effects Of Lyophilization and Reconstitution On Blank Micellesmentioning

confidence: 99%

Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-b-ε-caprolactone) Micelles

et al. 2023

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Polymeric micelles are promising carriers for the delivery of poorly water-soluble drugs, providing enhanced drug solubility, blood circulation times, and bioavailability. Nevertheless, the storage and long-term stability of micelles in solution present challenges requiring the lyophilization and storage of formulations in the solid state, with reconstitution immediately prior to application. Therefore, it is important to understand the effects of lyophilization/reconstitution on micelles, particularly their drug-loaded counterparts. Herein, we investigated the use of β-cyclodextrin (β-CD) as a cryoprotectant for the lyophilization/reconstitution of a library of poly(ethylene glycol-b-ε-caprolactone) (PEG-b-PCL) copolymer micelles and their drug-loaded counterparts, as well as the effect of the physiochemical properties of different drugs (phloretin and gossypol). The critical aggregation concentration (CAC) of the copolymers decreased with increasing weight fraction of the PCL block (fPCL), plateauing at ~1 mg/L when the fPCL was >0.45. The blank (empty) and drug-loaded micelles were lyophilized/reconstituted in the absence and presence of β-CD (9% w/w) and analyzed via dynamic light scattering (DLS) and synchrotron small-angle X-ray scattering (SAXS) to assess for changes in aggregate size (hydrodynamic diameter, Dh) and morphology, respectively. Regardless of the PEG-b-PCL copolymer or the use of β-CD, the blank micelles displayed poor redispersibility (<10% relative to the initial concentration), while the fraction that redispersed displayed similar Dh to the as-prepared micelles, increasing in Dh as the fPCL of the PEG-b-PCL copolymer increased. While most blank micelles displayed discrete morphologies, the addition of β-CD or lyophilization/reconstitution generally resulted in the formation of poorly defined aggregates. Similar results were also obtained for drug-loaded micelles, with the exception of several that retained their primary morphology following lyophilization/reconstitution, although no obvious trends were noted between the microstructure of the copolymers or the physicochemical properties of the drugs and their successful redispersion.

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Insight into the role of β-cyclodextrin on the hydration of white Portland cement

Wang

Chen

et al. 2023

Cement and Concrete Research

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Poly(Ethylene Glycol)/β-Cyclodextrin Pseudorotaxane Complexes as Sustainable Dispersing and Retarding Materials in a Cement-Based Mortar

Cited by 7 publications

References 41 publications

The Dual Modification of PNIPAM and β-Cyclodextrin Grafted on Hyaluronic Acid as Self-Assembled Nanogel for Curcumin Delivery

The Dual Modification of PNIPAM and β-Cyclodextrin Grafted on Hyaluronic Acid as Self-Assembled Nanogel for Curcumin Delivery

Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-b-ε-caprolactone) Micelles

Insight into the role of β-cyclodextrin on the hydration of white Portland cement

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