Poly(hydroxybutyrate-co-hydroxyvalerate) microparticles embedded in κ-carrageenan/locust bean gum hydrogel as a dual drug delivery carrier

Pettinelli, Natalia; Rodríguez-Llamazares, Saddys; Farrag, Yousof; Bouza, Rebeca; Barral, L.; Feijóo‐Bandín, Sandra; Lago, Francisca

doi:10.1016/j.ijbiomac.2019.12.193

Cited by 66 publications

(28 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, increasing temperature can cause the escape of 5-FU molecules from HAp-GEL composites, and the diffusion rate of 5-FU may be affected by temperature [65][66][67]. In this study, during the entire release process, the release rate and cumulative release percentage were affected by the temperature, while the diffusion rate of 5-FU was affected by the molecular thermal motion [70,87]. As seen in Figure 6, all HAp-GEL composites showed an initial burst and a 50% drug release in 20-25 minutes.…”

Section: Sem Analysis Of the Drug-loaded Hap-gel Compositesmentioning

confidence: 65%

“…Finally, the Higuchi model describes the drug release as a diffusion process based on Fick's law and is a square-root-of-time-dependent mechanism. This model is often applicable to different geometrics and porous systems [68][69][70][71][72].…”

Section: Release Kinetics Of 5-fumentioning

confidence: 99%

“…For the 2% GA and 5% GA composites, 55% and 50% of 5-FU were released at 37°C and 75% and 60% at 42°C within 5 min, respectively. This rapid initial release rate has been attributed to either the presence of nonencapsulated drug molecules on the surface of the microparticles or drug molecules that are close to the surface (immersed in the polymer matrix) [70]. For the 2% GA and 5% GA composites, the drug was almost completely released from the composites within 60 and 180 minutes, respectively.…”

Section: Sem Analysis Of the Drug-loaded Hap-gel Compositesmentioning

confidence: 99%

“…Figure 7 shows the drug release profiles of HAp-GEL composites with different amounts of GA at three different temperatures (32°C, 37°C, and 42°C). At each temperature, [70,87,89,90]. Because HAp-GEL with a 1 : 1 weight ratio had the highest drug loading efficiency [91], drug release studies were conducted on that sample for different GA ratios.…”

Section: Sem Analysis Of the Drug-loaded Hap-gel Compositesmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Temperature on Drug Release: Production of 5-FU-Encapsulated Hydroxyapatite-Gelatin Polymer Composites via Spray Drying and Analysis of In Vitro Kinetics

Aydın

2020

International Journal of Polymer Science

View full text Add to dashboard Cite

In this study, 5-fluorouracil- (5-FU-) loaded hydroxyapatite-gelatin (HAp-GEL) polymer composites were produced in the presence of a simulated body fluid (SBF) to investigate the effects of temperature and cross-linking agents on drug release. The composites were produced by wet precipitation at pH 7.4 and temperature 37°C using glutaraldehyde (GA) as the cross-linker. The effects of different amounts of glutaraldehyde on drug release profiles were studied. Encapsulation (drug loading) was performed with 5-FU using a spray drier, and the drug release of 5-FU from the HAp-GEL composites was determined at temperatures of 32°C, 37°C, and 42°C. Different mathematical models were used to obtain the release mechanism of the drug. The morphologies and structures of the composites were analyzed by X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, and scanning electron microscopy. The results demonstrated that for the HAp-GEL composites, the initial burst decreased with increasing GA content at all three studied temperatures. Further, three kinetic models were investigated, and it was determined that all the composites best fit the Higuchi model. It was concluded that the drug-loaded HAp-GEL composites have the potential to be used in drug delivery applications.

show abstract

Section: Sem Analysis Of the Drug-loaded Hap-gel Compositesmentioning

confidence: 65%

Section: Release Kinetics Of 5-fumentioning

confidence: 99%

Section: Sem Analysis Of the Drug-loaded Hap-gel Compositesmentioning

confidence: 99%

Section: Sem Analysis Of the Drug-loaded Hap-gel Compositesmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Temperature on Drug Release: Production of 5-FU-Encapsulated Hydroxyapatite-Gelatin Polymer Composites via Spray Drying and Analysis of In Vitro Kinetics

Aydın

2020

International Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

“…The major applications in the field of biomedicine are shown as a schematic layout in Figure 6 . CGs are applied in various pharmaceutical formulations, including tablets [ 106 , 108 ], suppositories [ 109 , 110 ], films [ 111 ], fast-dissolving inserts (FDIs) [ 63 ], beads [ 112 , 113 ], pellets [ 114 , 115 , 116 ], microparticles [ 117 , 118 , 119 ], nanoparticles [ 120 , 121 , 122 , 123 , 124 , 125 ], inhalable systems, injectables [ 126 ], and hydrogels [ 127 , 128 , 129 ]. In addition, recent studies have shown that CGs are promising candidates in tissue engineering, thanks to their similarity to native glycosaminoglycans [ 127 , 128 , 130 , 131 ].…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

View full text Add to dashboard Cite

Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

show abstract

Nanoengineering Palladium Plasmonic Nanosheets Inside Polymer Nanospheres for Photothermal Therapy and Targeted Drug Delivery

Usón

Yus

Mendoza

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

The incorporation of plasmonic nanoconstructs in biodegradable polymeric nanoparticles (NPs), together with therapeutic drugs in a controlled procedure is of interest for different applications in Nanomedicine. Advanced hybrid nanomaterials can be engineered by combining the in situ formation of plasmonic palladium nanosheets (NSs) and the proper ionic nature of the encapsulated drug. This study presents a new procedure to synthesize hybrid nanostructures by a Pickering double emulsion. Anisotropic palladium (Pd) NSs with unique near‐infrared (NIR)‐optical properties can be assembled within a poly lactic‐co‐glycolic acid matrix of < 200 nm NPs, when Pd precursors are in situ reduced via a gas‐phase procedure. The hybrid nanomaterials respond to external NIR light stimulus. The unprecedented precision to assemble, in a single stage, plasmonic nanoconstructs having a total loading selectivity, when encapsulated in combination with hydrophobic drugs, offers new opportunities in the new class of theragnostics, in particular when triggered drug delivery and photothermal therapies are required.

show abstract

Poly(hydroxybutyrate-co-hydroxyvalerate) microparticles embedded in κ-carrageenan/locust bean gum hydrogel as a dual drug delivery carrier

Cited by 66 publications

References 45 publications

Effect of Temperature on Drug Release: Production of 5-FU-Encapsulated Hydroxyapatite-Gelatin Polymer Composites via Spray Drying and Analysis of In Vitro Kinetics

Effect of Temperature on Drug Release: Production of 5-FU-Encapsulated Hydroxyapatite-Gelatin Polymer Composites via Spray Drying and Analysis of In Vitro Kinetics

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

Nanoengineering Palladium Plasmonic Nanosheets Inside Polymer Nanospheres for Photothermal Therapy and Targeted Drug Delivery

Contact Info

Product

Resources

About