Poly(L-Lactic Acid) Composite with Surface-Modified Magnesium Hydroxide Nanoparticles by Biodegradable Oligomer for Augmented Mechanical and Biological Properties

Abstract

Poly(L-lactic acid) (PLLA) has attracted a great deal of attention for its use in biomedical materials such as biodegradable vascular scaffolds due to its high biocompatibility. However, its inherent brittleness and inflammatory responses by acidic by-products of PLLA limit its application in biomedical materials. Magnesium hydroxide (MH) has drawn attention as a potential additive since it has a neutralizing effect. Despite the advantages of MH, the MH can be easily agglomerated, resulting in poor dispersion in the polymer matrix. To overcome this problem, oligo-L-lactide-ε-caprolactone (OLCL) as a flexible character was grafted onto the surface of MH nanoparticles due to its acid-neutralizing effect and was added to the PLLA to obtain PLLA/MH composites. The pH neutralization effect of MH was maintained after surface modification. In an in vitro cell experiment, the PLLA/MH composites including OLCL-grafted MH exhibited lower platelet adhesion, cytotoxicity, and inflammatory responses better than those of the control group. Taken together, these results prove that PLLA/MH composites including OLCL-grafted MH show excellent augmented mechanical and biological properties. This technology can be applied to biomedical materials for vascular devices such as biodegradable vascular scaffolds.

Multi-modulation of immune-inflammatory response using bioactive molecule-integrated PLGA composite for spinal fusion

“…The PLGA was a pivotal matrix of composites prepared using a previously reported solvent casting method [ 27 ] ( Fig. 1 A).…”

Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide

“…First, we synthesized mMH developed in our previous study [ 19 ]. In FTIR analysis of the mMH, both -OH stretching vibration of MH and the carbonyl peak were observed, and the carbonyl peak was shifted because of the formation of bidentate chelating ligands [ 28 ]. The mMH maintained its function, including pH neutralization and anti-inflammation, even after modification.…”

“…Fibrinogen selectively adsorbs on the hydrophobic surface and induces platelet adhesion [ 37 ]. Although mMH is surface-modified with a hydrophobic oligomer, the intrinsic hydrophilic property of MH had a lower water contact angle than that of PLLA [ 28 ]. The mMH in the BVS/EVL/mMH leads to more hydrophilicity than was induced by the BVS/EVL and inhibited fibrinogen adsorption.…”

“…The ODLLA-grafted MH particles (mMH) were synthesized as previously described [ 19 , 28 ]. The reaction was initiated by mixing stannous octoate (1/10,000 mol ratio of D,L-lactide), 1 g MH, and 1 g D,L-lactide.…”

PMMA-Grafted Calcium Sulfate Whiskers for Applications as Fillers in PVC

“…The dispersion of the fillers can be improved via surface modification of the inorganic particles by increasing the surface tension and roughness of the particles or changing their surface chemical properties to improve the adhesion between the particles and the matrix [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. For example, Yang et al [ 21 ] modified nanostructured calcium carbonate (nano-CaCO 3 ) with γ-(2,3-epoxypropyloxy)propyltrimethoxysilane (KH560), 3-(methacryloxy)propyltrimethoxysilane (KH570), or isopropyl dioleoyloxy(dioctyl phosphate acyloxy) titanate.…”