Poly(propylene imine) dendrimers modified with maltose or maltotriose protect phosphorothioate oligodeoxynucleotides against nuclease activity

Drzewińska, Joanna; Appelhans, Dietmar; Voit, Brigitte; Bryszewska, Maria; Klajnert, Barbara

doi:10.1016/j.bbrc.2012.09.043

Cited by 20 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to reduce the toxicity of PPI dendrimers, different chemical modifications of their surfaces have been established to neutralize the cationic charge. The replacement of some or all the cationic groups on fourth generation PPI dendrimer surfaces by maltose and maltotriose significantly reduced their toxicity [24]. Dense-shell glycodendrimers, described as amphiphilic macromolecules with a cationic core and a neutral surface charge (PPI dendrimers in which 100% of the available hydrogen atoms are substituted with maltose, PPI 100%malG3) have been found to be non-toxic to the cell lines studied [13,21,25].…”

Section: Resultsmentioning

confidence: 99%

Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents

et al. 2015

Self Cite

View full text Add to dashboard Cite

Besides acting as antimicrobial compounds, dendrimers can be considered as agents that improve the therapeutic effectiveness of existing antibiotics. In this work we present a new approach to using amoxicillin (AMX) against reference strains of common Gram-negative pathogens, alone and in combination with poly(propylene imine) (PPI) dendrimers, or derivatives thereof, in which 100% of the available hydrogen atoms are substituted with maltose (PPI 100%malG3). The concentrations of dendrimers used remained in the range non-toxic to eukaryotic cells. The results indicate that PPI dendrimers significantly enhance the antibacterial effect of amoxicillin alone, allowing antibiotic doses to be reduced. It is important to reduce doses of amoxicillin because its widespread use in medicine could lead to the development of bacterial resistance and environmental pollution. This is the first report on the combined antibacterial activity of PPI surface-modified maltose dendrimers and amoxicillin.

show abstract

Section: Resultsmentioning

confidence: 99%

Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…But none of the studied dendrimers protected ODNs against digestion at low pH (B4.5). 264 One of the important aspects of nucleic acids delivery to cells by dendrimers is their interaction with glucosaminoglycans (GAGs). GAGs are components of the extracellular matrix.…”

Section: Dendritic Glycopolymers As Drug Delivery Systemsmentioning

confidence: 99%

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

et al. 2015

Self Cite

View full text Add to dashboard Cite

In this review we highlight the potential for biomedical applications of dendritic glycopolymers based on polyamine scaffolds. The complex interplay of the molecular characteristics of the dendritic architectures and their specific interactions with various (bio)molecules are elucidated with various examples. A special role of the individual sugar units attached to the dendritic scaffolds and their density is identified, which govern ionic and H-bond interactions, and biological targeting, but to a large extent are also responsible for the significantly reduced toxicity of the dendritic glycopolymers compared to their polyamine scaffolds. Thus, the application of dendritic glycopolymers in drug delivery systems for gene transfection but also as therapeutics in neurodegenerative diseases has great promise.

show abstract

“…These carbohydrate-modified PPI G4 dendrimers protected oligonucleotides from nucleolytic degradation at neutral pH but in an acidic environment, the protective effect of these dendrimers was weaker. [75] A high molecular weight bioreducable polymer was synthesized by Nam et al . for gene delivery by incorporating arginine-grafted poly (disulfide amine) into the PAMAM dendrimer.…”

Section: Dendrimers For Gene Deliverymentioning

confidence: 99%

Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

et al. 2014

View full text Add to dashboard Cite

Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Moreover, high ratio of surface groups to molecular volume has made them a promising synthetic vector for gene delivery. Owing to these properties dendrimers have fascinated the researchers in the development of new drug carriers and they have been implicated in many therapeutic and biomedical applications. Despite of their extensive applications, their use in biological systems is limited due to toxicity issues associated with them. Considering this, the present review has focused on the different strategies of their synthesis, drug delivery and targeting, gene delivery and other biomedical applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems and associated approaches to alleviate their inherent toxicity.

show abstract

Poly(propylene imine) dendrimers modified with maltose or maltotriose protect phosphorothioate oligodeoxynucleotides against nuclease activity

Cited by 20 publications

References 27 publications

Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents

Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

Contact Info

Product

Resources

About