Poly(rC)-binding proteins as pleiotropic regulators in hematopoiesis and hematological malignancy

Abstract

Poly(rC)-binding proteins (PCBPs), a defined subfamily of RNA binding proteins, are characterized by their high affinity and sequence-specific interaction with poly-cytosine (poly-C). The PCBP family comprises five members, including hnRNP K and PCBP1-4. These proteins share a relatively similar structure motif, with triple hnRNP K homology (KH) domains responsible for recognizing and combining C-rich regions of mRNA and single- and double-stranded DNA. Numerous studies have indicated that PCBPs play a prominent role in hematopoietic cell growth, differentiation, and tumorigenesis at multiple levels of regulation. Herein, we summarized the currently available literature regarding the structural and functional divergence of various PCBP family members. Furthermore, we focused on their roles in normal hematopoiesis, particularly in erythropoiesis. More importantly, we also discussed and highlighted their involvement in carcinogenesis, including leukemia and lymphoma, aiming to clarify the pleiotropic roles and molecular mechanisms in the hematopoietic compartment.

SIVA-1 interaction with PCBP1 serves as a predictive biomarker for cisplatin sensitivity in gastric cancer and its inhibitory effect on tumor growth in vivo

“…In this study, we revealed that upregulation of SIVA-1 cooperates with DDP to inhibit tumor growth and promote MKN45/DDP cell apoptosis in vivo by increasing levels of PCBP1 and decreasing expression of Bcl-2 and Bcl-xL. Poly (rC)-binding proteins (PCBPs), a distinct subset within the RNA binding protein family, are distinguished by their strong affinity and specific interaction with poly-cytosine (poly-C) sequences 36 . The PCBP family consists of five members, which include hnRNP K (heterogeneous nuclear ribonucleoprotein K) along with PCBP1 through PCBP4 37 .…”