Poly Sulfoxyamine Grafted Chitosan as Bactericidal Dressing for Wound Healing

Abstract

In this study, sulfoxyamine derivative of chitosan was carried out by reaction with thionyl chloride and further treated with ammonia. FT-IR, 1H NMR, elemental analysis and DSC methods are used for confirmation of modification. The results revealed that the modified chitosan exhibits better water solubility than chitosan. The evaluation of the applicability of sulfoxyamine modified chitosan in the treatment of dermal wound in rats was performed by induction of transcutaneous wound. The antibacterial activity was tested on Gram-negative and Gram-positive strains. It was found that the modified chitosan showed grater activity against Gram-negative stains as compared to Gram-positive strains. The superior wound healing and antibacterial activity might be due to the grafting of additional cationic group on the polymeric backbone and their ionic interaction with anionic cell wall of skin or bacteria. Modified chitosan also showed significant physical properties like mucoadhesion and film forming or coating properties. The modified chitosan forms film with good adhesion on wound which will protect the wound and also allows gas exchange. These properties are beneficial for treatment of wounds. Similar to chitosan, modified chitosan showed non-toxicity in skin irritation, oral acute toxicity and cytotoxicity.

Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

“…The quaternization of chitosan can lead to materials with such improved antibacterial properties against several negative and Gram-positive bacteria [63][64][65][66]. It has also been reported that the addition of sulfoxyamine groups onto CS, produces a derivative with enhanced mucoadhesive and antibacterial properties [67]. Therefore, in this work, monomers carrying similar groups, such as tertiary amino groups and sulfoxide, have been chosen.…”

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

“…Except for quaternary CS derivatives, it was found that when carboxyl groups were grafted on CS chains, such as in the case of O-carboxymethyl CS (CMCS), antibacterial properties were further enhanced [99]. The introduction of sulfoxyamine groups in CS resulted in a derivative with simultaneously enhanced mucoadhesive and antibacterial properties [107].…”

Formulation and Characterization of Poly Sulfoxyamine Grafted Chitosan Coated Contact Lens

“…Modification was performed by our previous described method [14]. Chloro sulfoxy Chitosan was synthesized by mixing the 100 ml of pyridine with 10 gm of Chitosan.…”

“…Another class of agents is Quorum -sensing compound which potentially used for antimicrobial coating material to the Lens [13]. Other types of anti infective agents may be used to kill the infections organism or prevent them from causing infection [14].…”