Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

Monge, Sophie; Antoniacomi, Sarah; Lapinte, Vincent; Darcos, Vincent; Robin, Jean‐Jacques

doi:10.1039/c2py20309j

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…In fact, turbidimetry is one of the most widely used method for determining the LCST of thermoresponsive polymer solutions. The measurement can be performed on a simple UV–Vis spectrometer with temperature control 69 . Samples were dissolved in appropriate solvent (H 2 O/DMF) to obtain desired concentration (5 mg/mL).…”

Section: Methodsmentioning

confidence: 99%

Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

Dinari

Abdollahi

Majid

2021

Sci Rep

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The story of human dreams about curing all diseases, disorders and lesions is as old as human history. In the frontier of medical science, nanomedicine is trying to solve the problem. In this study, inspired by nanotechnology and using “grafting from” approach, a novel lignin-based nanogel was synthesized using atom transfer radical polymerization (ATRP) method. N-isopropylacrylamide (NIPAM) and N,N-dimethylaminoethylmethacrylate (DMAEMA) comonomers were graft copolymerized from fully brominated lignin as ATRP macroinitiator to synthesize lignin-g-P(NIPAM-co-DMAEMA) nanogel (LNDNG). By controlling the initial comonomer compositions and ATRP conditions, four LNDNG systems with different lower critical solution temperatures (LCSTs) of 32, 34, 37 and 42 °C were prepared. The LNDNGs were evaluated by GPC, FT-IR, 1H NMR, UV–Vis, DLS, SEM and TEM analyses. The prepared nanogels exhibited an average diameter of 150 nm with dual temperature and pH responsiveness. Curcumin (CUR) loading capacity and encapsulation efficiency of the LNDNGs were 49.69% and 92.62% on average, respectively. The cumulative release amount of loaded CUR was observed to be 65.36% after 72 h. The new lignin-based NGs proposed in the present work seems to be a promising, safe and comparable system in a near future.

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Section: Methodsmentioning

confidence: 99%

Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

Dinari

Abdollahi

Majid

2021

Sci Rep

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“…Generally, three kinds of thermo‐responsive polymers are classified. The first kind of thermo‐responsive polymers are those displaying phase transition in solvent at the lower critical solution temperature (LCST) . These LCST‐type thermo‐responsive polymers are molecularly soluble in solvent at temperature below LCST and become insoluble when temperature increases above LCST.…”

Section: Introductionmentioning

confidence: 99%

A new thermo-responsive block copolymer with tunable upper critical solution temperature and lower critical solution temperature in the alcohol/water mixture

Dan

Xiao

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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The multi-thermo-responsive block copolymer of poly [2-(2-methoxyethoxy)ethyl methacrylate]-block-poly[N-(4vinylbenzyl)-N,N-diethylamine] (PMEO 2 MA-b-PVEA) displaying phase transition at both the lower critical solution temperature (LCST) and the upper critical solution temperature (UCST) in the alcohol/water mixture is synthesized by reversible additionfragmentation chain transfer polymerization. The poly[2-(2methoxyethoxy)ethyl methacrylate] (PMEO 2 MA) block exhibits the UCST phase transition in alcohol and the LCST phase transition in water, while the poly[N-(4-vinylbenzyl)-N,N-diethylamine] (PVEA) block shows the UCST phase transition in isopropanol and the LCST phase transition in the alcohol/water mixture. Both the polymer molecular weight and the co-sol-vent/nonsolvent exert great influence on the LCST or UCST of the block copolymer. By adjusting the solvent character including the water content and the temperature, the block copolymer undergoes multiphase transition at LCST or UCST, and various block copolymer morphologies including inverted micelles, core-corona micelles, and corona-collapsed micelles are prepared.

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“…The T cp is defined as the temperature at which the phase transition of a polymer solution at a certain concentration from the soluble state to the collapsed state occurs, accompanied by the turbidity of the solution. This temperature can be determined by various methods, such as turbidimetry [ 83 ], 1 H NMR spectrosocopy [ 84 ], and dynamic light scattering [ 85 – 86 ]. In this context, the cloud-point is the phase transition temperature at a certain polymer concentration, which can be located at any point on the binodal curve, and therefore, the polymer concentration must be specified sets in the cloud-point determination.…”

Section: Reviewmentioning

confidence: 99%

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Flemming¹,

Münch²,

Fery³

et al. 2021

Beilstein J. Org. Chem.

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In the last decades, numerous stimuli-responsive polymers have been developed and investigated regarding their switching properties. In particular, thermoresponsive polymers, which form a miscibility gap with the ambient solvent with a lower or upper critical demixing point depending on the temperature, have been intensively studied in solution. For the application of such polymers in novel sensors, drug delivery systems or as multifunctional coatings, they typically have to be transferred into specific arrangements, such as micelles, polymer films or grafted nanoparticles. However, it turns out that the thermodynamic concept for the phase transition of free polymer chains fails, when thermoresponsive polymers are assembled into such sterically confined architectures. Whereas many published studies focus on synthetic aspects as well as individual applications of thermoresponsive polymers, the underlying structure–property relationships governing the thermoresponse of sterically constrained assemblies, are still poorly understood. Furthermore, the clear majority of publications deals with polymers that exhibit a lower critical solution temperature (LCST) behavior, with PNIPAAM as their main representative. In contrast, for polymer arrangements with an upper critical solution temperature (UCST), there is only limited knowledge about preparation, application and precise physical understanding of the phase transition. This review article provides an overview about the current knowledge of thermoresponsive polymers with limited mobility focusing on UCST behavior and the possibilities for influencing their thermoresponsive switching characteristics. It comprises star polymers, micelles as well as polymer chains grafted to flat substrates and particulate inorganic surfaces. The elaboration of the physicochemical interplay between the architecture of the polymer assembly and the resulting thermoresponsive switching behavior will be in the foreground of this consideration.

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Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

Cited by 20 publications

References 24 publications

Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

Design and fabrication of dual responsive lignin-based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release

A new thermo-responsive block copolymer with tunable upper critical solution temperature and lower critical solution temperature in the alcohol/water mixture

Constrained thermoresponsive polymers – new insights into fundamentals and applications

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