Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber

Functionalization of Silicone Rubber Surfaces towards Biomedical Applications

“…Moreover, when proteins are present they will cover an anti-adhesive surface and become microbial anchor points. [5,6]). …”

“…Th ese include easiness to mold and shape, fl exibility, mechanical stability, high gas permeability, stability and optical transparency, low toxicity combined with good blood biocompatibility, and low cost [5,6]. However, given their low surface free energy (hence poor wettability), they can cause adverse reactions such as tissue irritation, abrasion and ulceration [7][8][9][10][11].…”

Antimicrobial and Anti‐Inflammatory Intelligent Surfaces

“…60 Other nonfouling coatings have been produced by " grafting -to " or surface -initiated polymerization ( " grafting -from " ) of various hydrogel polymers. Several hydrogel coatings, for example, from PEG, 64 polyacrylamide, 16 and polylysine -PEG copolymers 14 have shown resistance to bacterial colonization. It must be noted, however, that in vivo fouling is more complex than what in vitro models can mimic at present, 63 and in vitro tests of protein and cell resistance may not directly translate to resistance to bacterial attachment in vivo .…”

The significant adhesion enhancement of Ag–polytetrafluoroethylene antibacterial coatings by using of molecular bridge

“…However, microbes adhered to it and formed biofilm easily because of its special surface properties, and biomaterial-centered infections happened [2]. Once the biofilm formed, it is very hard, or sometimes impossible, to remove it by washing or antibiotic treatment [3].…”