Polyacrylic acid mediated targeted drug delivery nano-systems: A review

Pourmadadi, Mehrab; Farokh, Arian; Rahmani, Elham; Eshaghi, Mohammad Mahdi; Aslani, Ali; Rahdar, Abbas; Ferreira, Luiz Fernando Romanholo

doi:10.1016/j.jddst.2023.104169

Cited by 27 publications

(8 citation statements)

References 128 publications

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“…This is particularly important in the case of organ transplantation, where the body’s immune system can sometimes identify the transplanted organ as foreign and attack it. Moreover, self-healing polymers can be used to create drug delivery systems within artificial organs [ 104 , 105 ]. This can help to deliver drugs or other therapeutic agents directly to the side of the organ, promoting healing and reducing the risk of rejection.…”

Section: Intrinsically Disordered Synthetic Polymersmentioning

confidence: 99%

Intrinsically Disordered Synthetic Polymers in Biomedical Applications

et al. 2023

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In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization and can be extremely useful in various biomedical applications. Among such applications, intrinsically disordered synthetic polymers can have potential usage in drug delivery, organ transplantation, artificial organ design, and immune compatibility. The designing of new syntheses and characterization mechanisms is currently required to provide the lacking intrinsically disordered synthetic polymers for biomedical applications bio-mimicked using intrinsically disordered proteins. Here, we present our strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on bio-mimicking intrinsically disordered proteins.

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Section: Intrinsically Disordered Synthetic Polymersmentioning

confidence: 99%

Intrinsically Disordered Synthetic Polymers in Biomedical Applications

et al. 2023

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“…Poly(acrylic acid) (PAA) is a nontoxic, antiviral synthetic polymer with mucoadhesive properties, a high-water absorption capacity, and a recyclable nature . PAA is pH-sensitive due to the presence of carboxylic acid, making PAA a promising polymer for drug delivery systems, particularly oral ones . Han et al demonstrated a TiO 2 NPs-based pH-responsive phototherapeutic PAA-calcium phosphate passivated drug delivery system for cancer treatment.…”

Section: Polymeric Nanoparticles In Drug Deliverymentioning

confidence: 99%

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

Rad,

Soylukan,

Kulabhusan

et al. 2023

ACS Appl. Mater. Interfaces

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“…Poly(acrylic acid) (PAA) finds applications in many sectors, including, but not limited to, drug delivery, adhesives, textiles and biomedical engineering. It is commonly used to produce hydrogel drug-releasing systems [12,13]. The presence of carboxyl groups in PAA macromolecules enables the direct functionalisation of hydrogels via chemical and physical cross-linking [14].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Ionic Polymers’ Stabilizing and Flocculating Properties in Dispersed Activated Carbons Systems

Gęca,

Wiśniewska,

Nowicki

2024

Materials

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Activated carbons obtained via the thermochemical treatment of lemon balm and mint herbs were applied for ionic polymers adsorption, which directly affects the stability of these types of aqueous suspensions. The examined carbonaceous materials were characterized by well-developed specific surface area (approximately 1000 m2/g) and mesoporous structure. The adsorbed amounts of anionic poly(acrylic acid) and cationic polyethyleneimine from one-component solutions reached significant levels, but the efficiency of adsorption of these compounds from binary solutions slightly decreased. Moreover, the ionic polymers showed stabilizing properties towards the activated carbons suspensions. For both adsorbents, the most stable suspensions were systems containing both types of polymeric macromolecules with different ionic characters. This was due to the occurrence of electrosteric and depletion stabilization mechanisms. Furthermore, the zeta potential and size of particle aggregates were also influenced by the presence of polymers in the aqueous suspensions of activated carbons.

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Polyacrylic acid mediated targeted drug delivery nano-systems: A review

Cited by 27 publications

References 128 publications

Intrinsically Disordered Synthetic Polymers in Biomedical Applications

Intrinsically Disordered Synthetic Polymers in Biomedical Applications

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

Investigation of Ionic Polymers’ Stabilizing and Flocculating Properties in Dispersed Activated Carbons Systems

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