Polyamine-RNA-membrane interactions: From the past to the future in biology

Acosta-Andrade, Carlos; Artetxe, Ibai; Lete, Marta G.; Monasterio, Bingen G.; Ruiz-Mirazo, Kepa; Goñi, Félix M.; Sánchez‐Jiménez, Francisca

doi:10.1016/j.colsurfb.2017.04.005

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…On the one hand, it is clear that some specific binding modes have been detected (among an immense quantity of possibilities for PA-biomolecules interactions) with physiological consequences or applications (for instance, nanotechnology applied to drug delivery) [ 141 ]. On the other hand, it is tempting to hypothesize that their interaction with both nucleic acids and membranes was of absolutely essential value from the beginning of life on Earth [ 142 ].…”

Section: Biochemistry and Physiology Of Polyaminesmentioning

confidence: 99%

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

Fernández-Reina

Urdiales

Sánchez‐Jiménez

2018

Foods

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Biogenic amines derived from basic and aromatic amino acids (B/A-BAs), polyamines, histamine, serotonin, and catecholamines are a group of molecules playing essential roles in many relevant physiological processes, including cell proliferation, immune response, nutrition and reproduction. All these physiological effects involve a variety of tissue-specific cellular receptors and signalling pathways, which conforms to a very complex network that is not yet well-characterized. Strong evidence has proved the importance of this group of molecules in the gastrointestinal context, also playing roles in several pathologies. This work is based on the hypothesis that integration of biomedical information helps to reach new translational actions. Thus, the major aim of this work is to combine scientific knowledge on biomolecules, metabolism and physiology of the main B/A-BAs involved in the pathophysiology of the gastrointestinal tract, in order to point out important gaps in information and other facts deserving further research efforts in order to connect molecular information with pathophysiological observations.

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Section: Biochemistry and Physiology Of Polyaminesmentioning

confidence: 99%

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

Fernández-Reina

Urdiales

Sánchez‐Jiménez

2018

Foods

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Polyamines in mammalian pathophysiology

Sánchez‐Jiménez

Medina

Villalobos-Rueda

et al. 2019

Cell. Mol. Life Sci.

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Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines

et al. 2022

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Polyamine (PA) catabolism is often reduced in cancer cells. The activation of this metabolic pathway produces cytotoxic substances that might cause apoptosis in cancer cells. Chemical compounds able to restore the level of PA catabolism in tumors could become potential antineoplastic agents. The search for activators of PA catabolism among bicyclononan-9-ones is a promising strategy for drug development. The aim of the study was to evaluate the biological activity of new 3,7-diazabicyclo[3.3.1]nonan-9-one derivatives that have antiproliferative properties by accelerating PA catabolism. Eight bispidine derivatives were synthetized and demonstrated the ability to activate PA catabolism in regenerating rat liver homogenates. However, only three of them demonstrated a potent ability to decrease the viability of cancer cells in the MTT assay. Compounds 4c and 4e could induce apoptosis more effectively in cancer HepG2 cells rather than in normal WI-38 fibroblasts. The lead compound 4e could significantly enhance cancer cell death, but not the death of normal cells if PAs were added to the cell culture media. Thus, the bispidine derivative 4e 3-(3-methoxypropyl)-7-[3-(1H-piperazin-1-yl)ethyl]-3,7-diazabicyclo[3.3.1]nonane could become a potential anticancer drug substance whose mechanism relies on the induction of PA catabolism in cancer cells.

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Polyamine-RNA-membrane interactions: From the past to the future in biology

Cited by 3 publications

References 74 publications

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

Polyamines in mammalian pathophysiology

Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines

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