Polyamines: Potential anti-inflammatory agents and their possible mechanism of action

Lagishetty, Chakradhar V.; Naik, Suresh R.

doi:10.4103/0253-7613.42305

Cited by 44 publications

(21 citation statements)

References 16 publications

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“…As such, spermidine and urolithin A have been shown to induce mitochondrial elimination promoting longevity and stress resistance in many organisms, including mice, flies, and nematodes ( 170 – 172 ). In addition to mitophagy, both spermidine and urolithin A present anti-inflammatory properties modulating mitochondrial metabolism and subsequently NF-κB activity ( 173 – 178 ).…”

Section: Discussionmentioning

confidence: 99%

The Role of Mitophagy in Innate Immunity

2018

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Mitochondria are cellular organelles essential for multiple biological processes, including energy production, metabolites biosynthesis, cell death, and immunological responses among others. Recent advances in the field of immunology research reveal the pivotal role of energy metabolism in innate immune cells fate and function. Therefore, the maintenance of mitochondrial network integrity and activity is a prerequisite for immune system homeostasis. Mitochondrial selective autophagy, known as mitophagy, surveils mitochondrial population eliminating superfluous and/or impaired organelles and mediating cellular survival and viability in response to injury/trauma and infection. Defective removal of damaged mitochondria leads to hyperactivation of inflammatory signaling pathways and subsequently to chronic systemic inflammation and development of inflammatory diseases. Here, we review the molecular mechanisms of mitophagy and highlight its critical role in the innate immune system homeostasis.

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Section: Discussionmentioning

confidence: 99%

The Role of Mitophagy in Innate Immunity

2018

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“…The consumer demand for bountiful nutritious produce has intensified since the recognition that biomolecules such as antioxidants (including phenolic compounds), vision-improving carotenoid β-carotene, and anti-cancerous carotenoid lycopene have the potential to enhance quality of life in humans and animals. Thus, due to their anti-oxidant and anti-inflammatory attributes, PAs as well have been implicated in beneficial effects on human health (Lagishetty and Naik, 2008 ). However, PA levels generally decline with aging in most organisms, from bacteria to mammals, which may play a significant role in aging and associated diseases.…”

Section: Comparison Of the Content Of Pas In Plants And Animalsmentioning

confidence: 99%

Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease

2018

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Biogenic amines—polyamines (PAs), particularly putrescine, spermidine and spermine are ubiquitous in all living cells. Their indispensable roles in many biochemical and physiological processes are becoming commonly known, including promoters of plant life and differential roles in human health and disease. PAs positively impact cellular functions in plants—exemplified by increasing longevity, reviving physiological memory, enhancing carbon and nitrogen resource allocation/signaling, as well as in plant development and responses to extreme environments. Thus, one or more PAs are commonly found in genomic and metabolomics studies using plants, particulary during different abiotic stresses. In humans, a general decline in PA levels with aging occurs parallel with some human health disorders. Also, high PA dose is detrimental to patients suffering from cancer, aging, innate immunity and cognitive impairment during Alzheimer and Parkinson diseases. A dichotomy exists in that while PAs may increase longevity and reduce some age-associated cardiovascular diseases, in disease conditions involving higher cellular proliferation, their intake has negative consequences. Thus, it is essential that PA levels be rigorously quantified in edible plant sources as well as in dietary meats. Such a database can be a guide for medical experts in order to recommend which foods/meats a patient may consume and which ones to avoid. Accordingly, designing both high and low polyamine diets for human consumption are in vogue, particularly in medical conditions where PA intake may be detrimental, for instance, cancer patients. In this review, literature data has been collated for the levels of the three main PAs, putrescine, spermidine and spermine, in different edible sources—vegetables, fruits, cereals, nuts, meat, sea food, cheese, milk, and eggs. Based on our analysis of vast literature, the effects of PAs in human/animal health fall into two broad, Yang and Yin, categories: beneficial for the physiological processes in healthy cells and detrimental under pathological conditions.

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“…For example, arabinose was only identified from the CSB food. Of the metabolites listed in Table 4 , those that had evidence of anti-inflammatory activity included putrescine, ribose, riboflavin (vitamin B-2), α-tocotrienol, and γ-tocotrienol in the CSB food; serotonin, dimethylglycine, and oleanolic acid in the CB food; and hypotaurine, dihydroquercetin (taxifolin), eriodictyol, quercetin 3-galactoside, quercetin 3-glucoside, and quercetin in the CP food ( 36 – 42 , 44 – 48 ).…”

Section: Resultsmentioning

confidence: 99%

The Nutrient and Metabolite Profile of 3 Complementary Legume Foods with Potential to Improve Gut Health in Rural Malawian Children

Borresen

Zhang

Trehan

et al. 2017

Current Developments in Nutrition

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Background: Environmental enteric dysfunction (EED), frequently seen in rural Malawian children, causes chronic inflammation and increases the risk of stunting. Legumes may be beneficial for improving nutrition and reducing the risk of developing EED in weaning children. Objective: The objectives of this study were to determine the nutritional value, verify the food safety, and identify metabolite profiles of 3 legume-based complementary foods: common bean (CB), cowpea (CP), and traditional corn-soy blend (CSB). Methods: Foods were prepared by using local ingredients and analyzed for nutrient composition with the use of Association of Official Analytical Chemists (AOAC) standards (950.46, 991.43, 992.15, 996.06, and 991.36) for macro- and micronutrient proximate analysis. Food safety analysis was conducted in accordance with the Environmental Protection Agency (7471B) and AOAC (2008.02) standards. The metabolite composition of foods was determined with nontargeted ultra-performance LC–tandem mass spectrometry metabolomics. Results: All foods provided similar energy; CB and CP foods contained higher protein and dietary fiber contents than did the CSB food. Iron and zinc were highest in the CSB and CP foods, whereas CB and CP foods contained higher amounts of magnesium, phosphorus, and potassium. A total of 652 distinct metabolites were identified across the 3 foods, and 23, 14, and 36 metabolites were specific to the CSB, CB, and CP foods, respectively. Among the potential dietary biomarkers of intake to distinguish legume foods were pipecolic acid and oleanolic acid for CB; arabinose and serotonin for CSB; and quercetin and α- and γ-tocopherol acid for CP. No heavy metals were detected, and aflatoxin was measured only in the CSB (5.2 parts per billion). Conclusions: Legumes in the diet provide a rich source of protein, dietary fiber, essential micronutrients, and phytochemicals that may reduce EED. These food metabolite analyses identified potential dietary biomarkers of legume intake for stool, urine, and blood detection that can be used in future studies to assess the relation between the distinct legumes consumed and health outcomes. This trial was registered at clinicaltrials.gov as NCT02472262 and NCT02472301.

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Polyamines: Potential anti-inflammatory agents and their possible mechanism of action

Cited by 44 publications

References 16 publications

The Role of Mitophagy in Innate Immunity

The Role of Mitophagy in Innate Immunity

Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease

The Nutrient and Metabolite Profile of 3 Complementary Legume Foods with Potential to Improve Gut Health in Rural Malawian Children

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