Polyarticular pigmented villonodular synovitis

Wagner, ML; Hj, Spjut; Rv, Dutton; Glassman, AL; Askew, JB

doi:10.2214/ajr.136.4.821

Cited by 34 publications

(15 citation statements)

References 6 publications

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“…Lesions are almost invariably monoarticular or solitary and are unassociated with other disorders (5). Polyarticular or multifocal involvement is distinctly unusual, but it appears more often in children, an otherwise rarely affected age group (11,(15)(16)(17). PVNS in children has also been associated with a variety of other abnormalities, including vascular lesions, cherubism, multiple lentigines syndrome, extremity lymphedema, Noonan syndrome, and jaw lesions (5,6).…”

Section: Clinical Characteristicsmentioning

confidence: 99%

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Rhee²,

et al. 2008

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Pigmented villonodular synovitis (PVNS) represents an uncommon benign neoplastic process that may involve the synovium of the joint diffusely or focally (PVNS) or that may occur extraarticularly in a bursa (pigmented villonodular bursitis [PVNB]) or tendon sheath (pigmented villonodular tenosynovitis [PVNTS]). Pathologic specimens of the hypertrophic synovium may appear villous, nodular, or villonodular, and hemosiderin deposition, often prominent, is seen in most cases. The knee, followed by the hip, is the most common location for PVNS or PVNB, whereas PVNTS occurs most often in the hand and foot. PVNTS is also referred to as giant cell tumor of the tendon sheath (GCTTS). PVNTS is the most common form of this disease by a ratio of approximately 3:1. Radiographs reveal nonspecific features of a joint effusion in PVNS, a focal soft-tissue mass in PVNB or PVNTS, or a normal appearance. Extrinsic erosion of bone (on both sides of the joint) may also be seen and is most frequent with intraarticular involvement of the hip (>90% of cases). Cross-sectional imaging reveals diffuse involvement of the synovium (PVNS), an intimate relationship to the tendon (PVTNS), or a typical bursal location (PVNB), findings that suggest the diagnosis. However, the magnetic resonance (MR) imaging findings of prominent low signal intensity (seen with T2-weighting) and "blooming" artifact from the hemosiderin (seen with gradient-echo sequences) are nearly pathognomonic of this diagnosis. In addition, MR imaging is optimal for evaluating lesion extent. This information is crucial to guide treatment and to achieve complete surgical resection. Recurrence is more common with diffuse intraarticular disease and is difficult to distinguish, both pathologically and radiologically, from the rare complication of malignant PVNS. Recognizing the appearances of the various types of PVNS, which reflect their pathologic characteristics, improves radiologic assessment and is important for optimal patient management.

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Section: Clinical Characteristicsmentioning

confidence: 99%

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Rhee²,

et al. 2008

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“…Peak incidence occurs during the third and fourth decades [Johansson et al, 19821. Multiple joint involvement, particularly at relatively young ages, is rare [Leszczynski et al, 1975;Lindenbaum and Hunt, 1977;Wagner et al, 1981;Walls and Nogi, 1985;Wendt et al, 19861. Bobechko and Kostuik [19681 reported two boys and one girl (ages 4, 5, and 10 years, respectively) who developed pigmented villonodular synovitis in one knee.…”

Section: Problems In Nosologymentioning

confidence: 99%

Noonan‐like/multiple giant cell lesion syndrome

1991

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A patient with the Noonan-like/multiple giant cell lesion syndrome is reported and the findings in 14 cases are reviewed. Impressive manifestations include short stature, low normal intelligence or developmental delay, ocular hypertelorism, prominent posteriorly angulated ears, giant cell lesions of bones, joints, and/or soft tissues, pectus excavatum, and pulmonic stenosis. It has been difficult to delineate the syndrome because problems in identifying the condition have resulted from incomplete or truncate ascertainment by various medical specialists.

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“…Notre patient ne rapportait aucune histoire traumatique. D'autres mécanismes tels que les troubles locaux du métabolisme du fer [4] ou encore les perturbations de la boucle synergique paracrine médiée par le TNFα (Tumor Necrosis Factor) et le CSF1 (High Synovial Colony Stimulating Factor 1) ont été également été incriminés comme les initiateurs de la SVN, mais n'expliquent pas cette localisation anatomique particulière.…”

Section: Discussionunclassified

Extensive pigmented villonodular synovitis of the ankle

et al. 2011

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La synovite villonodulaire (SVN) est une proliféra-tion synoviale localement agressive d'étiologie inconnue, pouvant toucher les articulations, les gaines tendineuses et les bourses. Sa localisation à l'articulation subtalaire est extrêmement rare. L'imagerie par résonance magnétique est réputé être performante pour la confirmation diagnostique et la limitation de la zone tumorale grâce aux anomalies de signal spécifiques des dépôts d'hémosidérine retrouvés au sein de la SVN. Nous rapportons l'observation d'un patient de 35 ans qui présentait des douleurs de la cheville droite. Le diagnostic de SVN sub-talaire retenu après étude histologique d'une pièce biopsiquea justifié la synovectomie chirurgicale dix huit mois après l'intervention ; le patient était asymptomatique. Pour citer cette revue : Méd. Chir. Pied 27 (2011). Mots clés Synovite villo nodulaire · Tumeur bénigne · Articulation sub-talaire · IRMAbstract Pigmented villonodular synovitis (PVNS) is a locally aggressive synovial proliferative disorder of unknown aetiology affecting the linings of joints, tendon sheaths, and bursae. PVNS is rare in foot and ankle with few case reports in the literature. We present a case of PVNS in an unusual location, the right ankle. Radiographic findings were suggestive of an unspecified tumor of the ankle region because of extensive soft tissue hypertrophy and bone erosion. Histology findings were in keeping with PVNS and the patient underwent surgical excision. To cite this journal: Méd. Chir. Pied 27 (2011).

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Polyarticular pigmented villonodular synovitis

Cited by 34 publications

References 6 publications

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Noonan‐like/multiple giant cell lesion syndrome

Extensive pigmented villonodular synovitis of the ankle

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