Polyborane-encapsulated PEGylated Liposomes Prepared Using Post-insertion Technique for Boron Neutron Capture Therapy

Takeuchi, Issei; Kanno, Yuudai; Uchiro, Hiromi; Makino, Kimiko

doi:10.5650/jos.ess19218

Cited by 13 publications

(16 citation statements)

References 25 publications

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“…In addition, the best results of BNCT studies and high concentrations of boron in the tumor, have recently been obtained by using the latest generation of boron agents, which significantly increase the selectivity of its delivery to tumor cells. These results have been obtained by using various types of liposomes [ 22 , 23 ], polymers [ 24 ], nanoparticles [ 25 , 26 , 27 ], mannopyranoside complexes [ 28 ] and an electrochemotherapy in combination with boron drugs [ 29 ]. Here we used LC salt, which, upon administration of Li ions, were nonselectively absorbed by tumor cells; therefore, it can be assumed that the creation of a special construction with Li based on a selective carrier, similar to boron drugs, will significantly increase the accumulation of Li in the tumor.…”

Section: Discussionmentioning

confidence: 99%

Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing Lithium Neutron Capture Therapy

Taskaeva

Kasatovа

Surodin

et al. 2023

Life

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Boron neutron capture therapy (BNCT) is one of the promising treatment methods for malignant melanoma. The main issue of this technology is the insufficient selectivity of 10B accumulation in tumor cells. As a result of the neutron absorption by boron, an 84% energy release occurred within the cell by the nuclear reaction 10B (n, α)7Li, which lead to tumor cell death. The use of lithium instead of boron brings a new unique opportunity—local 100% energy release—since all products of the 6Li (n, α)3H reaction have high linear energy transfer characteristics. The aim of this study was to determine the concentrations of Li in the tumor, skin, blood, brain and kidney in experimental animals with B16 melanoma and to analyze the potential Li toxicity after lithium carbonate administration at single doses of 300 and 400 mg/kg. Lithium carbonate was chosen since there is a long-term experience of its use in clinical practice for the treatment of psychiatric disorders. The inductively coupled plasma atomic emission spectrometry was used to evaluate Li concentrations in tissue samples. The accumulation efficiency of Li in the tumor was the highest at a time point of 30 min (22.4 µg/g; at a dose of 400 mg/kg). Despite the high lithium accumulation in the kidneys, the pathological changes in kidney tissues were not found. Thus, lithium may actually be used for the Li-NCT development and future studies can be conducted using 6Li and following irradiation of tumor cells using the schemes of lithium administration tested in this work.

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Section: Discussionmentioning

confidence: 99%

Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing Lithium Neutron Capture Therapy

Taskaeva

Kasatovа

Surodin

et al. 2023

Life

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“…Liposomes as boron carriers for BNCT have been synthesized and studied for decades [ 1 , 2 , 4 , 5 , 6 , 14 , 15 ] and the efficacy of PEGylated and other liposomes as boron carriers has been repeatedly demonstrated [ 6 , 16 , 17 , 18 , 19 , 20 ]. However, although the formulation of BSH encapsulated in the inner aqueous phase of liposomes shows a certain antitumor effect in vivo, the amount of boron that can be delivered by liposomes to tumor tissue might be insufficient for human applications and such liposomes have not been applied clinically.…”

Section: Discussionmentioning

confidence: 99%

A Novel Boron Lipid to Modify Liposomal Surfaces for Boron Neutron Capture Therapy

Shirakawa

Zaboronok

Nakai

et al. 2021

Cells

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Boron neutron capture therapy (BNCT) is a cancer treatment with clinically demonstrated efficacy using boronophenylalanine (BPA) and sodium mercaptododecaborate (BSH). However, tumor tissue selectivity of BSH and retention of BPA in tumor cells is a constant problem. To ensure boron accumulation and retention in tumor tissues, we designed a novel polyethylene glycol (PEG)-based boron-containing lipid (PBL) and examined the potency of delivery of boron using novel PBL-containing liposomes, facilitated by the enhanced permeability and retention (EPR) effect. PBL was synthesized by the reaction of distearoylphosphoethanolamine and BSH linked by PEG with Michael addition while liposomes modified using PBL were prepared from the mixed lipid at a constant molar ratio. In this manner, novel boron liposomes featuring BSH in the liposomal surfaces, instead of being encapsulated in the inner aqueous phase or incorporated in the lipid bilayer membrane, were prepared. These PBL liposomes also carry additional payload capacity for more boron compounds (or anticancer agents) in their inner aqueous phase. The findings demonstrated that PBL liposomes are promising candidates to effect suitable boron accumulation for BNCT.

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“…Purified water was used as the external liquid and was replaced after 2, 4, 6, and 8 h. After dialysis, RFXloaded PLLGA nanoparticle suspensions were obtained. The mean volume diameters and size distributions of the nanoparticles were determined using a dynamic light scattering system ELSZ-2, Otsuka Electronics Co., Ltd., Hirakata, Japan , which measures the scattered light that is generated when the laser light is irradiated onto particles that are in Brownian motion at 25 28 .…”

Section: Preparation Of Rfx-loaded Pllga Nanoparticlesmentioning

confidence: 99%

Effects of Polyvinyl Alcohol on Drug Release from Nanocomposite Particles Using Poly (L-lactide-<i>co</i>-glycolide)

2021

Self Cite

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namic diameter of 1-3 μm are deposited minimally in the mouth and throat and maximally in the lung parenchymal regions, such as the alveolar or deep-lung region 5 . Thus, inhalable nanocomposite particles are a promising inhalation system. Furthermore, nanoparticles can overcome mucus clearance 6 . In addition to macrophages, they are also taken up by other cells such as cancer cells and epithelial cells 7 10 . These properties of nanoparticles are useful for drug delivery; however, the size of nanoparticles is not suitable for inhalation. Nanocomposite particles with an aerodynamic diameter suitable for inhalation are used to solve this problem. Since these particles use diluents soluble in the alveoli lining fluid, they are decomposed into nanoparticles after reaching the alveoli 10 . Recently, it was reported that nanocomposite particles for inhalation improved the concentration of drug in the lungs. These

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Polyborane-encapsulated PEGylated Liposomes Prepared Using Post-insertion Technique for Boron Neutron Capture Therapy

Cited by 13 publications

References 25 publications

Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing Lithium Neutron Capture Therapy

Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing Lithium Neutron Capture Therapy

A Novel Boron Lipid to Modify Liposomal Surfaces for Boron Neutron Capture Therapy

Effects of Polyvinyl Alcohol on Drug Release from Nanocomposite Particles Using Poly (L-lactide-<i>co</i>-glycolide)

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