Polybrominated Diphenyl Ethers (PBDEs) in a Large, Highly Polluted Freshwater Lake, China: Occurrence, Fate, and Risk Assessment

Liu, Jianchao; Lu, Guanghua; Zhang, Fuhai; Nkoom, Matthew; Yan, Zhenhua; Wu, Donghai

doi:10.3390/ijerph15071529

Cited by 25 publications

(7 citation statements)

References 51 publications

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“…It is reported that the aquatic concentration of BDE-47 in a real environment could be as high as 29 μg/L in polluted water, which helped verify the environmental relevance of our concentration setting. Meanwhile, the biota BDE-47 levels were determined in the range of 0.12–0.48 μg/g in 5 dpf larvae, which were comparable or even a bit lower than the common level of PBDE in fish as previously reported (0.562–1.61 μg/g). − , …”

Section: Resultsmentioning

confidence: 45%

“…Meanwhile, the biota BDE-47 levels were determined in the range of 0.12−0.48 μg/ g in 5 dpf larvae, which were comparable or even a bit lower than the common level of PBDE in fish as previously reported (0.562−1.61 μg/g). [30][31][32][33]59 BDE-47 Disturbed the Melanopsin System of Larvae. We first closely examined the effects of BDE-47 on the melanopsin system of zebrafish larvae (Figure 1).…”

Section: ■ Resultsmentioning

confidence: 99%

“…Due to their structural stability, , PBDEs remain ubiquitously present in the environment. The levels of PBDEs were as high as 29 μg/L in polluted water and commonly detected at levels of μg/g to mg/g dry weight in biota samples. − Therefore, the long-term health consequences of PBDEs remain non-negligible. The adverse effects of PBDEs are diverse and complicated, characterized by endocrine thyroid disruption, − reproduction toxicity, − and visual impairment. , Great research concerns are focused on the neurotoxicity of PBDEs, especially at the early stages of life .…”

Section: Introductionmentioning

confidence: 99%

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BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism

Cao

Zhang

et al. 2023

Environ. Sci. Technol.

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Depression is a high-incidence mood disorder that is frequently accompanied by sleep disturbances, which can be triggered by the non-image-forming (NIF) visual system. Therefore, we hypothesize that polybrominated diphenyl ethers are known to induce visual impairment that could promote depression by disrupting the NIF visual pathway. In this study, zebrafish larvae were exposed to BDE-47 at environmentally relevant concentrations (2.5 and 25 μg/L). BDE-47 caused melanopsin genes that dominate the NIF visual system that fell at night (p < 0.05) but rose in the morning (p < 0.05). Such bidirectional difference transmitted to clock genes and neuropeptides in the suprachiasmatic nucleus and impacted the adjacent serotonin system. However, indicative factors of depression, including serta, htr1aa, and aanat2, were unidirectionally increased 1.3- to 1.6-fold (p < 0.05). They were consistent with the increase in nighttime thigmotaxis (p < 0.05) and circadian hypoactivity (p < 0.05). The results of melanopsin antagonism also indicated that these consequences were possibly due to the combination of direct photoentrainment by melanopsin and circadian disruption originating from melanopsin. Collectively, our findings revealed that BDE-47 exposure disrupted the NIF visual pathway and resulted in depression-like effects, which may further exert profound health effects like mood disorders.

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Section: Resultsmentioning

confidence: 45%

Section: ■ Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism

Cao

Zhang

et al. 2023

Environ. Sci. Technol.

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“…PBDEs often bind to particles in the atmosphere and accumulate in water, sediments, and soil and in human and animal fatty tissues, posing a great threat to the environment and human health [ 3 ]. Previous studies reported that concentrations of pg/L to ng/L PBDEs have been found in water samples, while pg/g to ng/g dw have been found in soil and sediments samples, and pg/m 3 to ng/m 3 in air [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Assessment of the Toxicity of Brominated and Halogen-Free Flame Retardants to Zebrafish in Terms of Tail Coiling Activity, Biomarkers, and Locomotor Activity

Rialto,

Marino,

Abe

et al. 2023

Toxics

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BDE-47, a flame retardant that is frequently detected in environmental compartments and human tissues, has been associated with various toxic effects. In turn, information about the effects of aluminum diethyl-phosphinate (ALPI), a halogen-free flame retardant from a newer generation, is limited. This study aims to assess and compare the toxicity of BDE-47 and ALPI to zebrafish by analyzing the tail coiling, locomotor, acetylcholinesterase activities, and oxidative stress biomarkers. At 3000 µg/L BDE-47, the coiling frequency increased at 26–27 h post-fertilization (hpf), but the burst activity (%) and mean burst duration (s) did not change significantly. Here, we considered that the increased coiling frequency is a slight neurotoxic effect because locomotor activity was impaired at 144 hpf and 300 µg/L BDE-47. Moreover, we hypothesized that oxidative stress could be involved in the BDE-47 toxicity mechanisms. In contrast, only at 30,000 µg/L did ALPI increase the catalase activity, while the motor behavior during different developmental stages remained unaffected. On the basis of these findings, BDE-47 is more toxic than ALPI.

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“…With the rapid economic growth and urban development during the last several decades, the lake has been seriously polluted by wastewater and waste from industry, agriculture and daily life. Many studies have shown that Lake Chaohu is a significant sink for organic pollutants [28,29,30,31,32]. A previous study, conducted in 2011, reported the occurrence of PFAAs in Lake Chaohu, where long-chain PFAAs (e.g., PFOA) was the predominant PFAA in the surface water [33].…”

Section: Introductionmentioning

confidence: 99%

Occurrence, Removal and Bioaccumulation of Perfluoroalkyl Substances in Lake Chaohu, China

Pan

Zhang³

et al. 2019

IJERPH

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The perfluoroalkyl substances (PFAAs) have received growing attention in recent years as emerging contaminants in the aquatic environment. The occurrence, removal and bioaccumulation of fourteen PFAAs (C4–C14 carboxylate; C4, C6, C8 sulfonates) were investigated in Lake Chaohu, China. The concentrations of the selected PFAAs in inflowing river, lake water and sewage treatment plant (STP) samples were analyzed by ultra performance liquid chromatograph (UPLC–MS/MS). The results showed that perfluorohexanesulfonic acid (PFHxS), perfluorobutane sulfonate (PFBS), perfluorobutyric acid (PFBA) and perfluoropentanoic acid (PFPeA), instead of perfluorooctanoic acid (PFOA), were predominant PFAAs in the inflowing river and lake water with maximum concentrations in the ranges of 52.2–1866 and 27–236 ng L−1, respectively. The highest concentrations of total PFAAs were detected in the western rivers. The effluents from seven STPs were likely important sources of PFAAs in surface water, and the amount of the daily fluxes in the effluent were 132 g for short-chain PFAAs and 109 g for long-chain PFAAs. PFAAs were widely detected in Chinese icefish (Neosalanx tangkahkeii taihuensis) collected from Lake Chaohu, with maximal concentrations ranging from 1.79 ng g−1 to 50.9 ng g−1. The logarithmic bioaccumulation factors of perfluorodecanoic acid (PFDA, 3.5), perfluorooctane sulfonate (PFOS, 3.35) and perfluorononanoic acid (PFNA, 3.31) indicated the bioaccumulation of these long-chain PFAAs. This study is useful for enhancing our understanding of the pollution profiles of PFAAs and their environmental health risk in the freshwater lake.

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Polybrominated Diphenyl Ethers (PBDEs) in a Large, Highly Polluted Freshwater Lake, China: Occurrence, Fate, and Risk Assessment

Cited by 25 publications

References 51 publications

BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism

BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism

Comparative Assessment of the Toxicity of Brominated and Halogen-Free Flame Retardants to Zebrafish in Terms of Tail Coiling Activity, Biomarkers, and Locomotor Activity

Occurrence, Removal and Bioaccumulation of Perfluoroalkyl Substances in Lake Chaohu, China

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