Polychlorinated biphenyls (PCBs) as inducers of microsomal enzyme activity in the house fly

Rhee, K.S.; Plapp, Frederick W.

doi:10.1007/bf01986007

Cited by 16 publications

(2 citation statements)

References 27 publications

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“…Insects represent the largest group and largest terrestrial biomass in the animal kingdom and occupy critical positions in many food chains. Many insects have an active and well-defined cytochrome P enzyme system which is induced and inhibited by the same types of compounds as in vertebrates Metcalf, 1970, 1973;Hansen and Hodgson, 1971;Hodgson, 1985;Feyereisen et al, 1989;Rhee and Plapp, 1973). They can efficiently metabolize lipophilic PCBs in a selective manner (Saghir and Hansen, 1992;Saghir et al, 1993, resulting in major changes in the congener profiles of retained residues (Hansen and Storr-Hansen, 1992;Storr-Hansen et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Toxicity and Tissue Distribution of 2,2′,4,4′- and 3,3′,4,4′-Tetrachlorobiphenyls in Houseflies

Saghir

Hansen

1999

Ecotoxicology and Environmental Safety

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Section: Introductionmentioning

confidence: 99%

Toxicity and Tissue Distribution of 2,2′,4,4′- and 3,3′,4,4′-Tetrachlorobiphenyls in Houseflies

Saghir

Hansen

1999

Ecotoxicology and Environmental Safety

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“…The structure-activity relationship of this induction of enzyme activity has been considered, but no clear-cut patterns have been observed (2,4). Microsomal enzyme induction by organochlorines has been demonstrated in a wide variety of species, from primates (5) to flies (6).…”

Section: Introductionmentioning

confidence: 99%

Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.

Peakall¹

1976

Environ Health Perspect

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Rats were given a single dose of toxaphene (120 mg/kg, equivalent to 1/2 LD5o) and sacrificed at 1, 5, and 15 days. Liver weight and hepatic microsomal enzyme activity were increased at day 5 and 15. The level of plasma testosterone was significantly decreased at day 15. In a second experiment rats were given 2.4 mg/kg daily and sacrificed at 1, 3 and 6 months. Liver weights and microsomal enzyme activity were significantly increased over controls; enzyme activity was, however, decreasing by the end of the experiment. Plasma testosterone levels were not affected. It is concluded that enhanced hepatic enzyme induction causes only a transient drop in circulating testosterone levels followed by a return to normal values.

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Placental and mammary transfer of a polychlorinated biphenyl mixture (aroclor 1254) in the European Ferret (Mustela putorius furo)

Bleavins

Breslin

Aulerich

et al. 1984

Enviro Toxic and Chemistry

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Adult female ferrets were found to absorb 85.4% of a single dietary dose of the polychlorinated biphenyl (PCB) mixture Aroclor 1254. Excretion in the days immediately following dosing yielded the greatest quantity of PCBs eliminated in a given time period. In general, urinary excretion represented one‐tenth or less of the PCBs excreted via the feces. Placental transfer to the ferret kits was 0.01% (per kit) of the female's absorbed dose when exposure occurred during the first trimester of pregnancy and 0.04% (per kit) when the PCBs were administered during the third trimester. Transplacental exposure to PCBs was considerably less than that reaching the kits through the dam's milk. The ratio of placental to mammary transfer, following 1 week of lactation, was calculated to be approximately 1:15 for the offspring of first‐trimester‐dosed females and 1:7 for the offspring produced by females treated during the third trimester.

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Polychlorinated biphenyls (PCBs) as inducers of microsomal enzyme activity in the house fly

Cited by 16 publications

References 27 publications

Toxicity and Tissue Distribution of 2,2′,4,4′- and 3,3′,4,4′-Tetrachlorobiphenyls in Houseflies

Toxicity and Tissue Distribution of 2,2′,4,4′- and 3,3′,4,4′-Tetrachlorobiphenyls in Houseflies

Effects of toxaphene on hepatic enzyme induction and circulating steroid levels in the rat.

Placental and mammary transfer of a polychlorinated biphenyl mixture (aroclor 1254) in the European Ferret (Mustela putorius furo)

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