Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China

Yu, Dawei; Liu, Xiaofang; Xiao, Ling; Cao, Wencheng; Zhang, Xiaotian; Tian, He; Wang, Jin; Xiang, Nan; Wen, Shi Wu; Wu, Yongning; Sun, Xin; Zhou, Yan

doi:10.3390/ijerph16122178

Cited by 17 publications

(13 citation statements)

References 45 publications

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“…The results presented in Sections 3.1, 3.3.6 and 3.3.7 predict that PCDDs may bind to TRs (TR α and TR β) and thus mimic the binding behavior of thyromimetic GC-1. When properly activated by its endogenous ligand (thyroxine or triiodothyronine), TRs are responsible for the regulation of metabolism, growth, heart rate and brain development (Brent, 1994;Brent, 2000;Havey & Williams, 2002;Plateroti, Bernal, Refetoff, & Sachs, 2011;Tata, 2011;Yen, 2001 (Pavuk et al, 2003;Yu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Theoretical study on endocrine disrupting effects of polychlorinated dibenzo‐p‐dioxins using molecular docking simulation

Akinola

Uzairu

Shallangwa

et al. 2020

J of Applied Toxicology

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Polychlorinated dibenzo-p-dioxins (PCDDs) are hypothesized to exert their toxic effects in wildlife and humans via endocrine disruption. However, very scanty information is available on the underlying molecular interactions that trigger this disruption. In this study, molecular docking simulation was used to predict the susceptibility of 12 nuclear receptors to disruption via PCDD bindings. Findings revealed that androgen (AR and AR an), estrogen (ER α and ER β), glucocorticoid (GR) and thyroid hormone (TR α and TR β) receptors are the most probable protein targets that bind to PCDDs. Further molecular docking analyses showed that PCDD molecules mimic the modes of interaction observed for the co-crystallized ligands of the affected receptors, resulting in the formation of ligand-receptor complexes that were stabilized through electrostatic, van der Waals, pi-effect and hydrophobic interactions with 18, 17, 17, 16, 18, eight and four amino acid residues in the active sites of AR, AR an, ER α, ER β, GR, TR α and TR β respectively. The commonalities of these interacting amino acid residues with those utilized by dihydrotestosterone in AR, bicalutamide in AR an, 17β-estradiol in ER α, 17β-estradiol in ER β, cortisol in GR, thyromimetic GC-1 in TR α and thyromimetic GC-1 in TR β are 86%, 74%, 94%, 80%, 82%, 50% and 43% respectively. The results obtained in this study provide supporting evidence that PCDD molecules may interfere with the endocrine system via binding interactions with some vital amino acid residues in the binding pockets of AR, ERs, GRs and TRs.

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Section: Discussionmentioning

confidence: 99%

“…The results presented here for the binding of PCDD molecules to TRs may be useful in providing explanation to the observed toxic effects of PCDDs on humans and animals. Exposure to PCDDs is associated with growth retardation in fetuses and infants, thyroid disorder and neurodevelopmental dysfunction (Pavuk et al, 2003; Yu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Theoretical study on endocrine disrupting effects of polychlorinated dibenzo‐p‐dioxins using molecular docking simulation

Akinola

Uzairu

Shallangwa

et al. 2020

J of Applied Toxicology

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“…polychlorined dibenzodioxin -PCDD, polybrominated dibenzodioxin -PBDD) oraz polichlorowane i poli bromowane dibenzofurany (ang. polychlorined dibenzofurans -PCDF, polybrominated dibenzofurans -PBDF) [49,50]. Źródłem przedostawania się dioksyn i furanów do śro dowiska jest spalanie w zbyt niskiej temperaturze i przy nieodpowiednim udziale tlenu odpadów, w skład których wchodzą substancje chemiczne zawierające chlor lub sub stancje organiczne pochodzące z odpadów komunalnych czy szlamów z oczyszczalni ścieków.…”

Section: Dioksyny I Furanyunclassified

Effect of environmental factors on occurrence of male infertility

Bomba¹,

Rusin²

2021

Med Og Nauk Zdr.

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Wprowadzenie. Niepłodność to niemożność uzyskania ciąży w ciągu jednego roku u pary aktywnej seksualnie, nie stosującej antykoncepcji. Obecnie problem ten dotyka ok. 10-20% par. Wśród przyczyn niepłodności męskiej wyróżnia się czynniki przedjądrowe, jądrowe oraz pozajądrowe. Cel pracy. Celem pracy jest przegląd dostępnych danych literaturowych na temat wpływu poszczególnych, wybranych czynników środowiskowych na zjawisko niepłodności w populacji mężczyzn. Skrócony opis stanu wiedzy. Liczne badania wykazały postępujące obniżenie jakości nasienia w populacji mężczyzn. Jednym z czynników odpowiedzialnych za występowanie tego zjawiska mogą być obecne w środowisku metale ciężkie, takie jak ołów, rtęć oraz kadm, a także powszechnie stosowane pestycydy, bisfenol A, jak również dioksyny i furany zaliczane do trwałych związków organicznych. Substancje te negatywnie wpływają na gospodarkę hormonalną organizmu, a także uszkadzają komórki Sertoliego i Leydiga, czego konsekwencją może być zmniejszona liczba i ruchliwość plemników. Styl życia również odgrywa znaczącą rolę w utrzymaniu płodności wśród mężczyzn. Niewłaściwa dieta, palenie tytoniu i spożywanie alkoholu wpływają między innymi na obniżenie poziomu testosteronu oraz uszkodzenie materiału genetycznego plemników. Podsumowanie. Wiele substancji chemicznych może negatywnie wpływać na płodność mężczyzn. Należy dążyć do zmniejszenia narażenia na zanieczyszczenia występujące w środowisku oraz do poprawy stylu życia, aktywności fizycznej oraz rezygnacji z używek.

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“…OCDD was the predominant congener, followed by 1,2,3,6,7,8-HxCDD and 1,2,3,4,6,7,8-HpCDD, while concentrations of 2,3,7,8-TCDD, were particularly low. In a recent study, Yu et al [69] analyzed the concentrations of 17 PCDD/F and 12 dioxin-like (dl)-PCB congener profiles in 24 umbilical cord serum samples from pregnant women living near the Dagu Chemical Company (Tianjin, China). The aim of that study was to establish the trend of change of dioxins in local pregnant women, as well as to assess the health risks related to fetal exposure.…”

Section: Chinamentioning

confidence: 99%

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Marquès

Domingo

2019

IJERPH

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Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) are environmental pollutants with great persistence, the capacity of bioaccumulation, and well known important toxic effects in humans and animals. Incinerators of hazardous, municipal and medical waste, chlorine bleaching of paper pulp, cement plants, and the traffic of motor vehicles are the most frequent emission sources of these compounds. The diet, followed at a great distance by inhalation, is generally the main way of human exposure to PCDD/Fs. Human biomonitoring is of great importance to prevent potential adverse effects derived from exposure to chemicals such as PCDD/Fs. In relation to this, blood is among the most used biological monitors. In the current review, we have summarized the recent information (2000–2009) published in the scientific literature (databases: Scopus and PubMed) on the concentrations of PCDD/Fs in blood samples of non-occupationally exposed populations, as well as in some groups of occupationally exposed individuals. We have revised a number of studies conducted in various African, American, Asian and European countries, and Australia. Unfortunately, the information is quite limited. No data are available for most countries over the world. Based on the results here reviewed, where available, the current health risks for the general populations do not seem to be of concern. Moreover, taking into account the important reductions observed in the levels of PCDD/Fs in foodstuffs, new decreases in the concentrations of PCDD/Fs in blood—and other biological tissues—are very probable in the immediate years.

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Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China

Cited by 17 publications

References 45 publications

Theoretical study on endocrine disrupting effects of polychlorinated dibenzo‐p‐dioxins using molecular docking simulation

Theoretical study on endocrine disrupting effects of polychlorinated dibenzo‐p‐dioxins using molecular docking simulation

Effect of environmental factors on occurrence of male infertility

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

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