Polycyclic aromatic hydrocarbons (PAH): Carcinogenicity data and risk extrapolations

Kramers, P.G.N.; Heijden, C.A. van der

doi:10.1080/02772248809357271

Cited by 26 publications

(13 citation statements)

References 22 publications

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“…Kramers has recently evaluated the potential human intake and risks of PAHs in the diet and in air pollution (6). The estimated PAH intake from the diet exceed PAH in take from air; however, the risk from the diet was estimated to be less than the risk from air (6). An (10).…”

Section: Pahs In Foodstuffsmentioning

confidence: 99%

Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

Dunn¹

1991

Environmental Health Perspectives

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In anorganim with actrve nmtaboc systems for a given carcinogen, adducts are generally much longer lived than the carcinogens that formed them. Thus, the detection ofDNA-or protdn-carcinogen adductsin aquatic foodstuffs can act as anindicatorofprior carnog exposur The presnee ofDNA adducts would, in addition, suggest a mutagenic/carcinogenic risk to the aquatic orn itself. Wrtebrate fish are chacterized by high levels ofcarcinogen metabolism, low body burdens ofcarcinogen, the formation ofcarcinogen-macromolecule adducs, and theoccurrence ofpollutionrelated tumor Shellfish, on the other hand, h elowlevesofcarclnogenmetabos, high body burdens ofarcinogen, and have little or no evidence ofcarcinogen-macromolecule adductsor tums Th consumpton ofcarcinogen adducts in aquatic foodt Is unlkely to reprent a human helth hazard. There are no metaboik pathways by which proteincarcinogen or DNA-carcinogen adducts could reform carcnogen Incorporation via salage pathways of prformed mucleoside-carcinogen adducts from fo ts into newly syntbeized human DNA is theo lly ponsihIe However, absolute levelsofnucleoside-carcinogen leves in aquatic foodstuffs from polluted areas arevery low, and the incorporation of peormed adducts into DNA is songly discrminated against by the fidelity of DNA synthesis.

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Section: Pahs In Foodstuffsmentioning

confidence: 99%

Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

Dunn¹

1991

Environmental Health Perspectives

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“…United States National Research Council classified these organic contaminants into high and low molecular weight hydrocarbons, oxygenated, halogenated aliphatics, aromatics, nitro aromatics hydrocarbons and alkanes (NRC 2000;Abrajano and Yan 2014). These hydrocarbons and alkanes have been considered as priority pollutants (NRC 2000;Ekperusi and Aigbodion 2015), which are biohazards and biomagnified in the environment (Kramer and Van der Heijden 1990;Mohamed et al 2006). While, there are special group of microorganisms that can biodegrade and biotransform these hydrocarbons and alkanes to assimilate as biomass in the ecosystem (Chikere et al 2012;Rajasekar et al 2012;Roy et al 2015;Kumar et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Enzyme-mediated biodegradation of long-chain n-alkanes (C32 and C40) by thermophilic bacteria

et al. 2017

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Removal of long-chain hydrocarbons and nalkanes from oil-contaminated environments are mere important to reduce the ecological damages, while bioaugmentation is a very promising technology that requires highly efficient microbes. In present study, the efficiency of pure isolates, i.e., Geobacillus thermoparaffinivorans IR2, Geobacillus stearothermophillus IR4 and Bacillus licheniformis MN6 and mixed consortium on degradation of long-chain n-alkanes C 32 and C 40 was investigated by batch cultivation test. Biodegradation efficiencies were found high for C 32 by mixed consortium (90%) than pure strains, while the pure strains were better in degradation of C 40 than mixed consortium (87%). In contrast, the maximum alkane hydroxylase activities (161 lmol mg -1 protein) were recorded in mixed consortium system that had supplied with C 40 as sole carbon source. Also, the alcohol dehydrogenase (71 lmol mg -1 protein) and lipase activity (57 lmol mg -1 protein) were found high. Along with the enzyme activities, the hydrophobicity natures of the bacterial strains were found to determine the degradation efficiency of the hydrocarbons. Thus, the study suggested that the hydrophobicity of the bacteria is a critical parameter to understand the biodegradation of n-alkanes.

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“…Diesel oil is a complex mixture of normal, branched and cyclic alkanes and aromatic compounds with the properties of low water solubility, high adsorption coefficient and high stability of the aromatic ring (Dean et al, 2002;Kanaly and Harayama, 2002;Kropp and Fedorak, 1998;Van et al, 2003). Therefore, diesel fuel has been considered as priority pollutants which exert bio-hazardous effects on both human and other living organisms in the environment (Kramer and Van 1990;Refaat et al, 2008;Richardson, 1996). Fortunately, this mixture represents an excellent substrate in the study of hydrocarbon biodegradation due to its composition (Bicca et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of a novel native Bacillus strain capable of degrading diesel fuel

Kebria

Ahmad

Ganjidoust

et al. 2009

Int. J. Environ. Sci. Technol.

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ABSTRACT:The ability of native bacteria to utilize diesel fuel as the sole carbon and energy source was investigated in this research. Ten bacterial strains were isolated from the oil refinery field in Tehran, Iran. Two biodegradation experiments were performed in low and high (500 and 10000 ppm, respectively) concentration of diesel fuel for 15 days. Only two isolates were able to efficiently degrade the petroleum hydrocarbons in the first test and degraded 86.67 % and, 80.60 % of diesel fuel, respectively. The secondary experiment was performed to investigate the toxicity effect of diesel fuel at high concentration (10000 ppm). Only one strain was capable to degrade 85.20 % of diesel fuel at the same time (15 days). Phenotype and phylogeny analysis of this strain was characterized and identified as dieseldegrading bacteria, based on gram staining, biochemical tests, 16S rRNA gene sequence analysis. These results indicate that this new strain was Bacillus sp. and could be considered as Bacillus Cereus with 98 % 16 S rRNA gene sequence similarity. The results indicate that native strains have great potential for in situ remediation of diesel-contaminated soils in oil refinery sites.

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Polycyclic aromatic hydrocarbons (PAH): Carcinogenicity data and risk extrapolations

Cited by 26 publications

References 22 publications

Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

Enzyme-mediated biodegradation of long-chain n-alkanes (C32 and C40) by thermophilic bacteria

Isolation and characterization of a novel native Bacillus strain capable of degrading diesel fuel

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