Polycyclic aromatic hydrocarbons regulate the pigmentation pathway and induce DNA damage responses in keratinocytes, a process driven by systemic immunity

Chan, Taizan; Bramono, Diah S.; Bourokba, Nasrine; Vedula, Sri Ram Krishna; Wang, Siew Tein; Neo, Boon Hoe; Lim, Rebecca Y.X.; Kim, Hyoju; Misra, Namita; Lim, Shawn; Betts, Richard J.

doi:10.1016/j.jdermsci.2021.09.003

Cited by 6 publications

(4 citation statements)

References 48 publications

(50 reference statements)

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“…In this regard, it has been shown that tobacco smoke extract induced MMP-1 expression via activation of AhR signaling pathway in human fibroblasts and keratinocytes (Ono et al, 2013). Supportive evidence regarding the contribution of pollutants and tobacco to skin hyperpigmentation via ROS is also provided by multiple other studies (Vierkötter et al, 2010;Cho et al, 2012;Ishiwata et al, 2013;Delijewski et al, 2014;Peng et al, 2017;Leijs et al, 2018;Milani et al, 2019;Khmaladze et al, 2020;Krutmann et al, 2020;Suo et al, 2020;Yang et al, 2020;Chan et al, 2021;Grether-Beck et al, 2021;Moon et al, 2022) discussed in detail in Table 1.…”

Section: Oxidative Stress Pathwaysmentioning

confidence: 78%

“…For example, genes targeted by AhR were shown to be induced by UVB irradiation ( Noakes, 2015 ). In sum, skin’s exposure to environmental stimuli can activate hyperpigmentation via AhR activation and subsequent increase of TYR activity, melanin synthesis, and upregulation of TYRP-1, DCT, and MITF expression ( Krutmann et al, 2008 ; Luecke et al, 2010 ; Nakamura et al, 2013 ; Nakamura et al, 2016 ; Abbas et al, 2017 ; Leijs et al, 2018 ; Chan et al, 2021 ; Shi et al, 2021 ; Ahn et al, 2022 ) ( Table 1 ).…”

Section: Intracellular Signaling Pathways Crosstalk: Impacts Of Air P...mentioning

confidence: 99%

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Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

Bouchard,

Costin

2023

Front. Toxicol.

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Aging is one of the most dynamic biological processes in the human body and is known to carry significant impacts on individuals’ self-esteem. Skin pigmentation is a highly heritable trait made possible by complex, strictly controlled cellular and molecular mechanisms. Genetic, environmental and endocrine factors contribute to the modulation of melanin’s amount, type and distribution in the skin layers. One of the hallmarks of extrinsic skin aging induced by environmental stress factors is the alteration of the constitutive pigmentation pattern clinically defined as senile lentigines and/or melasma or other pigmentary dyschromias. The complexity of pollutants and tobacco smoke as environmental stress factors warrants a thorough understanding of the mechanisms by which they impact skin pigmentation through repeated and long-term exposure. Pre-clinical and clinical studies demonstrated that pollutants are known to induce reactive oxygen species (ROS) or inflammatory events that lead directly or indirectly to skin hyperpigmentation. Another mechanistic direction is provided by Aryl hydrocarbon Receptors (AhR) which were shown to mediate processes leading to skin hyperpigmentation in response to pollutants by regulation of melanogenic enzymes and transcription factors involved in melanin biosynthesis pathway. In this context, we will discuss a diverse range of New Approach Methodologies (NAMs) capable to provide mechanistic insights of the cellular and molecular pathways involved in the action of environmental stress factors on skin pigmentation and to support the design of raw ingredients and formulations intended to counter their impact and of any subsequently needed clinical studies.

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Section: Oxidative Stress Pathwaysmentioning

confidence: 78%

Section: Intracellular Signaling Pathways Crosstalk: Impacts Of Air P...mentioning

confidence: 99%

Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

Bouchard,

Costin

2023

Front. Toxicol.

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“…Previous studies also have shown that UVB affected epidermal morphology, disrupted the skin barrier, increased transepidermal water loss, and decreased stratum corneum hydration ( 31 ). Initially, melanin pigmentation plays a dual role in skin:it is suggested to render photoprotection from the DNA-damaging effects of UV ( 32 , 33 ) while leading to acquired hyperpigmentation disorders such as melasma ( 34 , 35 ). In this context, consumers have an increasing requirement for quality natural cosmetic material.…”

Section: Discussionmentioning

confidence: 99%

Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study

He²,

Chen³

et al. 2023

Front. Nutr.

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IntroductionDairy products have long been regarded as a controversial nutrient for the skin. However, a clear demonstration of donkey milk (DM) on skincare is required.MethodsIn this study, spectrum and chemical component analyses were applied to DM. Then, the effects of DM on UVB-induced skin barrier damage and melanin pigmentation were first evaluated in vitro and in vivo. Cell survival, animal models, and expression of filaggrin (FLG) were determined to confirm the effect of DM on UVB-induced skin barrier damage. Melanogenesis and tyrosinase (TYR) activity were assessed after UVB irradiation to clarify the effect of DM on whitening activities. Further, a network pharmacology method was applied to study the interaction between DM ingredients and UVB-induced skin injury. Meanwhile, an analysis of the melanogenesis molecular target network was developed and validated to predict the melanogenesis regulators in DM.ResultsDM was rich in cholesterols, fatty acids, vitamins and amino acids. The results of evaluation of whitening activities in vitro and in vivo indicated that DM had a potent inhibitory effect on melanin synthesis. The results of effects of DM on UVB‑induced skin barrier damage indicated that DM inhibited UVB-induced injury and restored skin barrier function via up-regulation expression of FLG (filaggrin). The pharmacological network of DM showed that DM regulated steroid biosynthesis and fatty acid metabolism in keratinocytes and 64 melanin targets which the main contributing role of DM might target melanogenesis, cell adhesion molecules (CAMs), and Tumor necrosis factor (TNF) pathway.DiscussionThese results highlight the potential use of DM as a promising agent for whitening and anti-photoaging applications.

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“…PAHs, a type of toxic constituents in PM, are known to be potential carcinogens and the main cause of lung cancer in the PM-exposed population, the underlying mechanism may include immune impairments. 40,41 Due to its sensitivity and specificity, urinary 1-OHP is usually used as a biomarker to evaluate high PAH exposure. 42 We found that urinary 1-OHP negatively associated with the levels of GATA3 or T-bet.…”

Section: Discussionmentioning

confidence: 99%

Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

Meng

Wang

et al. 2022

Environ. Sci. Technol.

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Compared with the T-cell potential of particulate matter (PM) in animal studies, comprehensive evaluation on the impairments of T-cell response and exposure−response from PM and its components in human population is limited. There were 768 participants in this study. We measured environmental PM and its polycyclic aromatic hydrocarbons (PAHs) and metals and urinary metabolite levels of PAHs and metals among population. T lymphocyte and its subpopulation (CD4 + T cells and CD8 + T cells) and the expressions of T-bet, GATA3, RORγt, and FoxP3 were measured. We explored the exposure−response of PM compositions by principal component analysis and mode of action by mediation analysis. There was a significant decreasing trend for T lymphocytes and the levels of T-bet and GATA3 with increased PM levels. Generally, there was a negative correlation between PM, urinary 1-hydroxypyrene, urinary metals, and the levels of T-bet and GATA3 expression. Additionally, CD4 + T lymphocytes were found to mediate the associations of PM 2.5 with T-bet expression. PM and its bound PAHs and metals could induce immune impairments by altering the T lymphocytes and genes of T-bet and GATA3.

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Polycyclic aromatic hydrocarbons regulate the pigmentation pathway and induce DNA damage responses in keratinocytes, a process driven by systemic immunity

Abstract: aromatic hydrocarbons regulate the pigmentation pathway and iinduce DNA damage responses in keratinocytes, a process driven by systemic immunity,

Cited by 6 publications

References 48 publications

Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study

Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

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