Polycyclic N‐Heterocyclic Compounds. Part 75: Synthesis of 2,4‐Disubstituted 5,6‐dihydro[1]benzoxepino[5,4‐d]pyrimidines and 12‐Substituted 1,2,4,5‐Tetrahydro[1]benzoxepino[4,5‐e]imidazo[1,2‐c]pyrimidines as Potential Antiplatelet Aggregators

Polycyclic N-Heterocyclic Compounds. Part 75. Synthesis of 2,4-Disubstituted 5,6-Dihydro[1]benzoxepino[5,4-d]pyrimidines and 12-Substituted 1,2,4,5-Tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines as Potential Antiplatelet Aggregators. -Several compound libraries are prepared including compounds (III) and other compounds derived from (III), e. g. by substitution of the chlorine moiety, including compounds (V). Evaluation of the compound libraries on collagen-induced platelet aggregation reveals compound (Vd) to be the most potent candidate among the tested compounds. -(OKUDA*, K.; YAMAMOTO, Y.; HIROTA, T.; SASAKI, K.; J. Heterocycl. Chem. 51 (2014) 4, 972-981, http://dx.doi.org/10.1002/jhet.1559 ; Lab. Med. Pharm. Chem., Gifu Pharm. Univ., Gifu 501-11, Japan; Eng.) -M. Tismer 04-194

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ChemInform Abstract: Polycyclic N‐Heterocyclic Compounds. Part 75. Synthesis of 2,4‐Disubstituted 5,6‐Dihydro[1]benzoxepino[5,4‐d]pyrimidines and 12‐Substituted 1,2,4,5‐Tetrahydro[1]benzoxepino[4,5‐e]imidazo[1,2‐c]pyrimidines as Potential Antiplatelet Aggregators.

Okuda

Yamamoto

Hirota

et al. 2015

ChemInform

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Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics

Ajani¹,

Isaac²,

Owoeye³

et al. 2015

International J. of Biological Chemistry

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The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1. Due to its prebiotic nature to living cells in biodiversity, it is an highly privileged motif for the development of molecules of biological and pharmaceutical interest. This present work deals with the exploration of chemistry and medicinal diversity of pyrimidine which might pave way to long await discovery in therapeutic medicine for future drug design.

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Polycyclic N‐Heterocyclic Compounds. Part 75: Synthesis of 2,4‐Disubstituted 5,6‐dihydro[1]benzoxepino[5,4‐d]pyrimidines and 12‐Substituted 1,2,4,5‐Tetrahydro[1]benzoxepino[4,5‐e]imidazo[1,2‐c]pyrimidines as Potential Antiplatelet Aggregators

Cited by 2 publications

References 37 publications

ChemInform Abstract: Polycyclic N‐Heterocyclic Compounds. Part 75. Synthesis of 2,4‐Disubstituted 5,6‐Dihydro[1]benzoxepino[5,4‐d]pyrimidines and 12‐Substituted 1,2,4,5‐Tetrahydro[1]benzoxepino[4,5‐e]imidazo[1,2‐c]pyrimidines as Potential Antiplatelet Aggregators.

ChemInform Abstract: Polycyclic N‐Heterocyclic Compounds. Part 75. Synthesis of 2,4‐Disubstituted 5,6‐Dihydro[1]benzoxepino[5,4‐d]pyrimidines and 12‐Substituted 1,2,4,5‐Tetrahydro[1]benzoxepino[4,5‐e]imidazo[1,2‐c]pyrimidines as Potential Antiplatelet Aggregators.

Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics

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