Polycyclic naphthalenediimide-based nanoparticles for NIR-II fluorescence imaging guided phototherapy

Tang, Chuanchao; Song, Chuanhui; Zheng, Wei; Liang, Chao; Ran, Jianchuan; Cai, Yu; Dong, Xiaochen; Han, Wei

doi:10.1007/s11426-020-9723-9

Cited by 34 publications

(20 citation statements)

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“…Another novel naphthalenediimide-based polycyclic fluorophore NDI-NA could form J -aggregates via nanoprecipitation, which caused a pronounced red-shift in both absorption and emission. 150 Besides, NDI-NA NPs presented a photothermal conversion efficiency of 30.8%.…”

Section: Nir-ii Organic Small Molecular Fluorophoresmentioning

confidence: 98%

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Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

et al. 2021

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Summary Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis and precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence imaging exhibits the merits of high accuracy and specificity, as well as real-time detection. Among the NIR-II fluorophores, organic small molecular fluorophores have shown superior properties in the biocompatibility, variable structure, and tunable emission wavelength than the inorganic NIR-II materials. What's more, some small molecular fluorophores also display excellent cytotoxicity when illuminated with the NIR laser. This review summarizes the progress of small molecular NIR-II fluorophores with different central cores for cancer phototheranostics in the past few years, focusing on the molecular structures and phototheranostic performances. Furthermore, challenges and prospects of future development toward clinical translation are discussed.

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Section: Nir-ii Organic Small Molecular Fluorophoresmentioning

confidence: 98%

“… 149 NDI-NA J-aggregates DSPE-mPEG2000 / 904/1,020 0.21% FLI PTT/PDT Imaging-guided PTT/PDT of tumor Tang et al. 150 IPIC TPP-PEG-PPG-PEG-TPP / N.A. 0.22% FLI PTT/PDT Imaging-guided mitochondria-targeting PTT/PDT of tumor Wang et al.…”

Section: Nir-ii Organic Small Molecular Fluorophoresmentioning

confidence: 99%

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

et al. 2021

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“…NDI‐NA NPs present excellent NIR‐II FLI capability, efficient ROS generation, and high photothermal conversion efficiency (30.8%), making them remarkably satisfying in NIR‐II imaging‐guided cancer phototherapy. [ 136 ] Small molecules not only exhibit efficient photodynamic/photothermal property but also act as fluorescent imaging probes for imaging‐guided PTT with good bio‐safety in the NIR region. Especially, indocyanine green is the only organic NIR dye approved by the U.S. Food and Drug Administration (FDA) for human medical imaging and diagnosis in clinical applications.…”

Section: Organic Npsmentioning

confidence: 99%

All‐in‐One Nanomedicine: Multifunctional Single‐Component Nanoparticles for Cancer Theranostics

Cai

Chen

et al. 2021

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The development of cancer diagnostic imaging and treatment is a major concern worldwide. By integrating imaging and therapy into one theranostic nanoplatform for simultaneously detecting tumors, evaluating the targeting ability and timely monitoring therapeutic responses provide more opportunities for precision medicine. Among various theranostic nanosystems, a series of single‐component nanoparticles (NPs) have been developed for “all‐in‐one” theranostics, which presents the unique properties of facile preparation, simple composition, defined structure, high reproducibility, and excellent biocompatibility. Specifically, utilizing single‐component NPs for both diagnostics and therapeutics can reduce the possible numerous untoward side effects and risks to the living body. In this review, the recent progress of multifunctional single‐component NPs in the applications of cancer theranostics is systematically summarized. Notably, the structure design, categories of NPs, targeted strategies, biomedical applications, potential barriers, challenges, and prospects for the future clinical practice of this rapidly growing field are discussed.

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Section: Introductionmentioning

confidence: 99%

NIR‐II Organic Nanotheranostics for Precision Oncotherapy

Dai

Wang

Shao

et al. 2021

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Precision oncotherapy can remove tumors without causing any apparent iatrogenic damage or irreversible side effects to normal tissues. Second nearinfrared (NIR-II) nanotheranostics can simultaneously perform diagnostic and therapeutic modalities in a single nanoplatform, which exhibits prominent perspectives in tumor precision treatment. Among all NIR-II nanotheranostics, NIR-II organic nanotheranostics have shown an exceptional promise for translation in clinical tumor treatment than NIR-II inorganic nanotheranostics in virtue of their good biocompatibility, excellent reproducibility, desirable excretion, and high biosafety. In this review, recent progress of NIR-II organic nanotheranostics with the integration of tumor diagnosis and therapy is systematically summarized, focusing on the theranostic modes and performances. Furthermore, the current status quo, problems, and challenges are discussed, aiming to provide a certain guiding significance for the future development of NIR-II organic nanotheranostics for precision oncotherapy.

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Polycyclic naphthalenediimide-based nanoparticles for NIR-II fluorescence imaging guided phototherapy

Cited by 34 publications

References 50 publications

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

All‐in‐One Nanomedicine: Multifunctional Single‐Component Nanoparticles for Cancer Theranostics

NIR‐II Organic Nanotheranostics for Precision Oncotherapy

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