2022
DOI: 10.3390/molecules27103334
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Polycyclic Phenol Derivatives from the Leaves of Spermacoce latifolia and Their Antibacterial and α-Glucosidase Inhibitory Activity

Abstract: Three new polycyclic phenol derivatives, 2-acetyl-4-hydroxy-6H-furo [2,3-g]chromen-6-one (1), 2-(1′,2′-dihydroxypropan-2′-yl)-4-hydroxy-6H-furo [2,3-g][1]benzopyran-6-one (2) and 3,8,10-trihydroxy-4,9-dimethoxy-6H-benzo[c]chromen-6-one (8), along with seven known ones (3–7, 9 and 10) were isolated for the first time from the leaves of Spermacoce latifolia. Their structures were determined by spectroscopic analysis and comparison with literature-reported data. These compounds were tested for their in vitro anti… Show more

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Cited by 6 publications
(1 citation statement)
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“…A polycyclic phenol with α-glucosidase inhibitory action was obtained from the leaves of Spermacoce latifolia Aubl. (Rubiaceae), named 3,8,10-trihydroxy-4,9-dimethoxy-6Hbenzo[c]chromen-6-one (67) (Figure 16) [113]. Considering the structural innovation, it has two methoxyls on the C-4 and C-9 carbons, differing from the known compound 3,4,8,9,10pentahydroxydibenzo[b,d]pyran-6-one, which has two hydroxyls on these same carbons.…”
Section: Phenolsmentioning
confidence: 99%
“…A polycyclic phenol with α-glucosidase inhibitory action was obtained from the leaves of Spermacoce latifolia Aubl. (Rubiaceae), named 3,8,10-trihydroxy-4,9-dimethoxy-6Hbenzo[c]chromen-6-one (67) (Figure 16) [113]. Considering the structural innovation, it has two methoxyls on the C-4 and C-9 carbons, differing from the known compound 3,4,8,9,10pentahydroxydibenzo[b,d]pyran-6-one, which has two hydroxyls on these same carbons.…”
Section: Phenolsmentioning
confidence: 99%