Polycystic Ovarian Syndrome and Eating Disorder: Are They Associated.

Abstract

Background: Polycystic ovarian syndrome is a common female endocrine disorder and affecting up to one in five women of reproductive age between 15-49 years. The etiology of polycystic ovarian syndrome is uncertain, but a number of risk factors are associated with polycystic ovarian syndrome is subfertility, obesity, insulin resistance, cardiovascular disease and hormonal disturbance. Hormonal imbalance, behavioral and cognitive health is related to abnormal eating habit like binge eating. Binge eating disorder is characterized by eating large amount of food in a discrete time period and feeling out of control. About one third women of polycystic ovarian syndrome reported binge eating disorder. Objective: To determine the association of binge eating disorder with polycystic ovarian syndrome in Civil Hospital of Karachi To determine the risk factors associated with polycystic ovarian syndrome in Civil Hospital of Karachi Methodology: This case control study was conducted in civil Hospital Karachi. Data was collected by using a structured questionnaire with a sample size of 280 (140 cases and 140 controls). Data entry was done in EpiData software and was analyzed by using SPSS Version 21. Descriptive analysis was performed for socio demographic variables. Univariate analysis was done to determine crude association between independent and dependent variables by calculating odds ratio and 95% confidence interval. Multivariable analysis was performed to eliminate the confounder Results: About 280 women (140 cases and 140 controls) were enrolled into the study. The Univariate analysis showed that polycystic ovarian syndrome among overweight women (BMI 25-29.9) was 2 times more (OR=2.0, 95 % CI=1.41-3.56, pvalue= 0.01) and among obese women (BMI ≥30) was 12 times more (OR=12.1, 95 % CI=5.03-29.24, pvalue=<0.001) as compared to control (normal BMI18.5-24.9) women kilogram per meter square , polycystic ovarian syndrome among binge eating disorder score (≥17) was found 4 times more (OR=4.3, 95 % CI=2.42-7.88, pvalue=<0.001) as compared to control non binge eating score (<17) women . Multivariate analysis showed polycystic ovarian syndrome among obese (BMI ≥30) was found ten times more (AOR=10.4, 95 % CI=4.11-26.4, pvalue=<0.001) as

Effect of hydrolysable tannin on nutrient intake obesity and other associated metabolic risk factors in polycystic rats

“…About 40-80 % of females with these conditions are reported to be overweight [2]. The clinical features of PCOS are hyperanderogenism while many other associated risk factors are insulin resistance, hyperglycemia, abnormal lipids and incidence of cardiovascular diseases (CVD) [3]. A number of pharmaceutical products are used for the treatment of PCOS which have shown deleterious side effects [4].…”