Polycystic ovary syndrome

Kar, PS; Cummings, MH

doi:10.1002/pdi.836

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Polycystic ovary syndrome (PCOS) is a complex endocrine disorder caused by hormone imbalance and often presents reproductive, metabolic and psychological syndromes ( 1 ). The reproductive syndromes mainly include ovulatory dysfunction, hyperandrogenism and polycystic ovaries, and the metabolic syndromes primarily include insulin resistance, obesity and dyslipidemia ( 2 , 3 ). The prevalence of PCOS is ~18% in women of productive age based on Rotterdam diagnostic criteria ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Pathway and network-based analysis of genome-wide association studies and RT-PCR validation in polycystic ovary syndrome

Shen

Zhou

Zheng

et al. 2017

International Journal of Molecular Medicine

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The purpose of this study was to identify promising candidate genes and pathways in polycystic ovary syndrome (PCOS). Microarray dataset GSE345269 obtained from the Gene Expression Omnibus database includes 7 granulosa cell samples from PCOS patients, and 3 normal granulosa cell samples. Differentially expressed genes (DEGs) were screened between PCOS and normal samples. Pathway enrichment analysis was conducted for DEGs using ClueGO and CluePedia plugin of Cytoscape. A Reactome functional interaction (FI) network of the DEGs was built using ReactomeFIViz, and then network modules were extracted, followed by pathway enrichment analysis for the modules. Expression of DEGs in granulosa cell samples was measured using quantitative RT-PCR. A total of 674 DEGs were retained, which were significantly enriched with inflammation and immune-related pathways. Eight modules were extracted from the Reactome FI network. Pathway enrichment analysis revealed significant pathways of each module: module 0, Regulation of RhoA activity and Signaling by Rho GTPases pathways shared ARHGAP4 and ARHGAP9; module 2, GlycoProtein VI-mediated activation cascade pathway was enriched with RHOG; module 3, Thromboxane A2 receptor signaling, Chemokine signaling pathway, CXCR4-mediated signaling events pathways were enriched with LYN, the hub gene of module 3. Results of RT-PCR confirmed the finding of the bioinformatic analysis that ARHGAP4, ARHGAP9, RHOG and LYN were significantly upregulated in PCOS. RhoA-related pathways, GlycoProtein VI-mediated activation cascade pathway, ARHGAP4, ARHGAP9, RHOG and LYN may be involved in the pathogenesis of PCOS.

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Section: Introductionmentioning

confidence: 99%

Pathway and network-based analysis of genome-wide association studies and RT-PCR validation in polycystic ovary syndrome

Shen

Zhou

Zheng

et al. 2017

International Journal of Molecular Medicine

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Understanding obesity in the older person: prevalence and risk factors

Haslam¹

2008

Br J Community Nurs

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District nurses deal with many overweight and obese clients on their caseloads. Many of these people have various co-morbities; their weight issues are often glossed over, prioritizing more pressing clinical issues. This however is a mistake, in this article the issue of obesity in the elderly is mapped out. It starts with looking at the reasons behind the epidemic and looking at individual factors. The elderly suffer from sarcopenia as a result of ageing which leads to changes in body morphology. If not tackled early, such changes lead to considerable increases in cardiometabolic risk. Widespread increases in BMI have been shown to promote CHD, hypertension, type 2 diabetes and certain types of cancers. Clinical depression can be a manifestation of obesity. An overview of the prevalence and non-conservative clinical management is given.

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The relationship between male testosterone hormone and some female hormones in women with polycystic ovary syndrome (PCOS)

Kadium

Kaem

Saeq

et al. 2016

J. Contemp. Med. Sci.

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Objectives This study was designed to determine the levels of hormones insulin, testosterone and some female hormones in some male and female hormones in patients with polycystic ovary syndrome (PCOS) and find the relationship between the male testosterone hormone and female hormones in patients with PCOS and to know the reasons for these changes in view of the prevalence of PCOS and its importance as a major problem affecting the health of women and her fertility.Methods The hormones included LH, FSH, PRL, estradiol (E2), progesterone (P4) and LH/FSH ratio in patients with PCOS compared with control group, and to find the relationship between male testosterone hormone and female hormones under the study in patients with PCOS. Fifty-five female patients with PCOS in reproductive age with body mass index (BMI) (25.01 ± 1.70 kg/m2), aged 15-46 years old and who recalculated fertility centre of teaching Al-Sadr hospital in Al-Najaf Al-Ashraf Governorate from 1/9/2013 to 1/10/2014, compared with 20 non-patients women with PCOS with BMI (23.87 ± 2.66 kg/m2) and age 17-47 years old as control group.Results The results showed that there was a significant increasing (p < 0.05) in insulin, testosterone, LH, PRL and LH/FSH ratio in patients with PCOS compared with control group, while there was a significant decreasing (p < 0.05) in FSH, E2 and P4 in patients with PCOS compared with non-patients women.Conclusion As the results have shown that there was a positive significant relationship between testosterone and LH, PRL and LH/FSH ratio while the relationship was negative significant between testosterone and FSH, E2 and P4 in patients with PCOS.

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Polycystic ovary syndrome

Cited by 3 publications

References 22 publications

Pathway and network-based analysis of genome-wide association studies and RT-PCR validation in polycystic ovary syndrome

Pathway and network-based analysis of genome-wide association studies and RT-PCR validation in polycystic ovary syndrome

Understanding obesity in the older person: prevalence and risk factors

The relationship between male testosterone hormone and some female hormones in women with polycystic ovary syndrome (PCOS)

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