Polydatin – a new mitochondria protector for acute severe hemorrhagic shock treatment

Wang, Xingmin; Song, Rui; Chen, Yunyan; Zhao, Ming; Zhao, Ke‐seng

doi:10.1517/13543784.2013.748033

Cited by 65 publications

(62 citation statements)

References 39 publications

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“…Increased lipid peroxides levels, lysosomal injury and mitochondrial permeability transition pore opening cause swollen mitochondria with poorly defined cristae, decreased mitochondrial membrane potential (DÉ) and reduced ATP content in neurons of rats after 2 h of shock, indicating mitochondrial dysfunction. However, PD evidently inhibits these alterations, which increases the ATP level from 44.14 AE 13.81% to 89.57 AE 9.21% and prolongs survival time from 6.3 AE 5.9 h to 31.6 AE 13.7 h. PD may be the best choice for protection of neuron against mitochondrial injury in severe shock (Wang et al, 2013).…”

Section: Anti-shock Effectsmentioning

confidence: 99%

Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

217

162

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Context: Polydatin, also named piceid (3,4 0 ,5-trihydroxystilbene-3-b-D-glucoside, PD), is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), but is also detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. There are numerous investigations reported of PD in the past 22 years, but they are usually scattered across various publications, which may block further research and clinical use of PD. Objective: The article summarizes and evaluates the published scientific information of PD pharmacological effects and pharmacokinetics since 1990. Materials and methods: The information from 98 cases included in this review was compiled using major databases such as MEDLINE, Elsevier, Springer, PubMed, Scholar and CNKI. Results: Numerous pharmacological investigations of PD mainly focus on cardiovascular effects, neuroprotection, anti-inflammatory and immunoregulatory effects, anti-oxidation, anti-tumor, liver and lung protection, etc. Conclusion: A great number of pharmacological and pharmacokinetic investigations in the past 22 years have demonstrated that PD has favorable therapeutic properties, indicating its potential as an effective material. However, further research is needed to explore its molecular mechanisms of action and definitive target proteins.

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Section: Anti-shock Effectsmentioning

confidence: 99%

Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

217

162

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“…On the basis of our previous experiments [20], PD was dissolved in warm NS (0.3 mL) and administered intravenously.…”

Section: Animals and Mods Modelmentioning

confidence: 99%

Polydatin: a new therapeutic agent against multiorgan dysfunction

Zeng

Chen

et al. 2015

Journal of Surgical Research

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“…Improvement in cognitive deterioration after ethanol administration , learning & memory impairment after hypoxicischemic brain injury (Sun et al, 2014), primary hippocampal cells survival rate, down regulation of cyclin dependent kinase 5 activity (Zhang et al) and up regulation of brain derived neurotrophic factor (Sun et al) have been reported after polydatin administration. High dose of polydatin (30 mg/kg/day) has shown an up regulation of glioma associated oncogenhomolog1 (Gli1), patched-1 (Ptch1) & superoxide dismutase 1 (SOD1), down regulation of NF-kB, reduction in infarct volume, brain water contents and improvement in behavioral deficit (Ji et al, 2012).Some authors have suggested that neuro protection offered by polydatin is likely by preventing the mitochondrial injury of the nervous tissue (Wang et al, 2013) or by its antiapoptotic property (Gao et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Potential of Polydatin Against Motor Abnormalities and Dopaminergic Neuronal Loss in Rotenone Induced Parkinson Model

Ahmed¹,

Shaikh²,

Baloch³

et al. 2018

Int. J. Morphol.

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SUMMARY:Among the neurodegenerative disorders, Parkinson disease (PD) is ranked as second most common. The pathological hallmark is selective degeneration of the dopaminergic neurons in the nigro-striatal regions of brain with appearance of the Lewy bodies. Present study explores the neuro-protective potential of polydatin in terms of amelioration of degeneration of dopaminergic neurons in nigro-striatal regions of brain and distorted neuromotor behavior in the rotenone model of Parkinson's disease. Thirty-six male Sprague Dawley rats were divided into three groups. Group A (control), Group B (rotenone treated) and Group C (rotenone+polydatin treated). Rotenone was administrated intraperitoneally (i.p) at a dose of 3 mg/kg/body weight while polydatin was given i.p. at a dose of 50 mg/ kg/body weight for four weeks. Then, animals were sacrificed; substantia nigra (SN) & striatum isolated from brain and five micron thick sections were prepared. Cresyl violet (CV), H&E and Immuno-histochemical staining using anti-TH antibody was done. Motor behavior was assessed weekly throughout the experiment using five different methods. Rotenone treated parkinsonian animals showed deterioration of motor behavior, weight loss, loss of dopaminergic neurons and diminished immune-reactivity in the sections from the nigrostriatal regions of these animals Polydatin+rotenone treatment showed contradicting effects to parkinsonism, with amelioration in weight loss, neuro-motor behavior, dopaminergic loss and immune-reactivity against dopaminergic neurons. Present study revealed a neuro-protective potential of polydatin in animal model of PD by ameliorating the neuro-motor abnormalities and degeneration of dopaminergic neurons in nigrostriatal regions.

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Polydatin – a new mitochondria protector for acute severe hemorrhagic shock treatment

Abstract: The study shows that neuronal mitochondrial injury is involved in the genesis of severe shock and PD may be the best choice for protection of neuron against mitochondrial injury in severe shock.

Cited by 65 publications

References 39 publications

Polydatin: A review of pharmacology and pharmacokinetics

Polydatin: A review of pharmacology and pharmacokinetics

Polydatin: a new therapeutic agent against multiorgan dysfunction

Neuroprotective Potential of Polydatin Against Motor Abnormalities and Dopaminergic Neuronal Loss in Rotenone Induced Parkinson Model

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