Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood–brain barrier permeability for its neuroprotective effect in pMCAO rat brain

Ji, Hui; Zhang, Xiangjian; Du, Yuanyuan; Liu, Haichao; Li, Shuya; Li, Litao

doi:10.1016/j.brainresbull.2011.09.021

Cited by 111 publications

(87 citation statements)

References 42 publications

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“…In the present study, the effective treatment of 30 or 45 mg/kg polydatin markedly reduced oxidative damage in CIA mice. Ji et al (14) demonstrated that treatment with polydatin ameliorates blood-brain barrier permeability through suppression of oxidative stress in the permanent middle cerebral artery occlusion rat brain (14). In agreement with previous studies, a study by Miao et al (15) demonstrated that polydatin protects against ischemia/reperfusion injury through antioxidative stress mechanisms (15).…”

Section: Discussionsupporting

confidence: 59%

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

Wang

2016

Molecular Medicine Reports

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Abstract. Polydatin is a natural extract used in traditional Chinese medicine, which leads to a marked improvement in the microcirculation perfusion and enhances the animal myocardial contraction force. The present study aimed to determine whether an effective treatment of polydatin ameliorates the symptoms of collagen-induced arthritis (CIA), and also to explore the potential mechanism. Male DBA/1J mice were induced into CIA model mice. The administration of polydatin effectively suppressed CIA in mice. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β) were effectively increased following the induction of CIA in the model mice compared with the control group. The elevated serum levels of MDA, SOD, TNF-α and IL-1β were markedly suppressed by the effective treatment of polydatin in CIA mice, compared with the CIA model group. However, an increase in the level of matrix metalloproteinase-9 (MMP-9) was markedly induced in the CIA mice compared with the control group. As compared with the CIA group, the expression of MMP-9 was substantially reduced by the effective treatment of polydatin. Taken together, the effective treatment of polydatin ameliorated the symptoms of CIA through an exertion of its antioxidative and anti-inflammatory effects, and also via activation of the expression of matrix metalloproteinase-9 (MMP-9) in mice.

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Section: Discussionsupporting

confidence: 59%

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

Wang

2016

Molecular Medicine Reports

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“…One of the mechanisms for lowering TNF-α levels may have been the anti-inflammatory properties of polydatin. Previous studies have indicated that polydatin from Polygonum cuspidatum may regulate the inflammatory response and immune function (10,12). For example, polydatin was identified to regulate IL-17 production in human peripheral blood mononuclear cells and nuclear factor κB activation in the rat model of cerebral artery occlusion (12,(28)(29).…”

Section: Discussionmentioning

confidence: 99%

“…One of the main properties of polydatin is the hepatoprotective activity, reportedly inducing gallbladder contraction, preventing biliary cholesterol-stone formation and protecting against tetrachloromethane and aflatoxin B1 hepatotoxicity (8)(9)(10)(11). It has also been demonstrated that polydatin suppresses the oxidative and inflammatory damage in ischemic stroke (12). In addition, it has been revealed that treatment with polydatin significantly reduced the serum levels of total cholesterol (TC) and TGs in hyperlipidemic hamsters and rabbits induced by a high-fat diet (HFD) (13,14).…”

Section: Introductionmentioning

confidence: 99%

Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c

Zhang

Tan

Yao

et al. 2012

Molecular Medicine Reports

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Abstract. The pathophysiology of non-alcoholic fatty liver disease remains incompletely elucidated, and available treatments are not entirely satisfactory. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspidatum, has been recognised to possess hepatoprotective and anti-inflammatory activities. The purpose of the present study was to determine whether polydatin has a protective effect against hepatic steatosis induced by a high-fat diet (HFD) and to elucidate its underlying molecular mechanisms in rats. Male Sprague-Dawley rats were randomly divided into four groups, including normal control, HFD model and polydatin-treated groups with polydatin levels of 30 and 90 mg/kg. Following the experimental period, plasma total cholesterol (TC), triglyceride (TG) and hepatic lipid concentrations were determined. To identify a possible mechanism, we examined the changes in liver tumor necrosis factor-α (TNF-α), lipid peroxidation levels and sterol-regulatory element binding protein (SREBP-1c) mRNA and its target genes. Both 30 and 90 mg/kg polydatin treatment alleviated hepatic steatosis and reduced plasma and liver TG, TC and free fatty acid (FFA) concentration significantly in HFD rats. In addition, TNF-α, and malondialdehyde and 4-hexanonenal levels were markedly suppressed by polydatin in the liver of HFD-fed rats. Polydatin also decreased the gene expression of SREBP-1c and its target genes involved in lipogenesis, including fatty acid synthase (FAS) and stearoly-CoA desaturase 1 (SCD1) in HFD-fed rats. These results suggest that the protective effects of polydatin against HFD-induced hepatic steatosis may be partly associated with reduced liver TNF-α expression, lipid peroxidation level and SREBP-1c-mediated lipogenesis.

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“…PD protects against the brain damage caused by permanent middle cerebral artery occlusion (MCAO) through up-regulating the expression of glioma-associated oncogene homolog1, patched-1 and SOD1, down-regulating the expression of NF-kB p65, and ameliorating blood-brain barrier permeability (Ji et al, 2012). Intravenous injection of PD can reduce the volume of brain infarction, improve neurological deficits, inhibit the expression of ICAM-1, VCAM-1, E-selectin, L-selectin and integrins after the operation of MCAO for 1 h (Cheng et al, 2006c).…”

Section: Neuroprotective Activitymentioning

confidence: 99%

Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

217

162

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Context: Polydatin, also named piceid (3,4 0 ,5-trihydroxystilbene-3-b-D-glucoside, PD), is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), but is also detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. There are numerous investigations reported of PD in the past 22 years, but they are usually scattered across various publications, which may block further research and clinical use of PD. Objective: The article summarizes and evaluates the published scientific information of PD pharmacological effects and pharmacokinetics since 1990. Materials and methods: The information from 98 cases included in this review was compiled using major databases such as MEDLINE, Elsevier, Springer, PubMed, Scholar and CNKI. Results: Numerous pharmacological investigations of PD mainly focus on cardiovascular effects, neuroprotection, anti-inflammatory and immunoregulatory effects, anti-oxidation, anti-tumor, liver and lung protection, etc. Conclusion: A great number of pharmacological and pharmacokinetic investigations in the past 22 years have demonstrated that PD has favorable therapeutic properties, indicating its potential as an effective material. However, further research is needed to explore its molecular mechanisms of action and definitive target proteins.

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Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood–brain barrier permeability for its neuroprotective effect in pMCAO rat brain

Cited by 111 publications

References 42 publications

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c

Polydatin: A review of pharmacology and pharmacokinetics

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