Polydocanol foam stabilized by liposomes: Supramolecular nanoconstructs for sclerotherapy

Cilurzo, Felisa; Critello, Costantino Davide; Paolino, Donatella; Fiorillo, Antonino S.; Fresta, Massimo; Franciscis, Stefano de; Celia, Christian

doi:10.1016/j.colsurfb.2018.12.027

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Liposomes were produced by using different lipid combinations (Table 1). Liposomes were obtained using the thin layer evaporation method, as described elsewhere [38]. Briefly, 40 mg of lipids were dissolved in chloroform/methanol (CH 3 OH/CHCl 3 ) (1: 3 v/v), then the organic solvent was removed by evaporation in a rotating evaporator Büchi Rotavapor R-210 at 90 rpm, at the mean (of the lipid mixture) transition temperature (Tm), for 30 min.…”

Section: Liposome Productionmentioning

confidence: 99%

Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy

et al. 2020

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Mesoporous silicon microparticles (MSMPs) can incorporate drug-carrying nanoparticles (NPs) into their pores. An NP-loaded MSMP is a multistage vector (MSV) that forms a Matryoshka-like structure that protects the therapeutic cargo from degradation and prevents its dilution in the circulation during delivery to tumor cells. We developed an MSV constituted by 1 µm discoidal MSMPs embedded with PEGylated liposomes containing oxaliplatin (oxa) which is a therapeutic agent for colorectal cancer (CRC). To obtain extra-small liposomes able to fit the 60 nm pores of MSMP, we tested several liposomal formulations, and identified two optimal compositions, with a prevalence of the rigid lipid 1,2-distearoyl-sn-glycero-3-phosphocholine and of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]. To improve the MSV assembly, we optimized the liposome-loading inside the MSMP and achieved a five-fold increase of the payload using an innovative lyophilization approach. This procedure also increased the load and limited dimensional changes of the liposomes released from the MSV in vitro. Lastly, we found that the cytotoxic efficacy of oxa-loaded liposomes and-oxa-liposome-MSV in CRC cell culture was similar to that of free oxa. This study increases knowledge about extra-small liposomes and their loading into porous materials and provides useful hints about alternative strategies for designing drug-encapsulating NPs.

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Section: Liposome Productionmentioning

confidence: 99%

Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy

et al. 2020

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“…Although non-fatal, varicosities can affect a patient's quality of life significantly through symptoms such as leg swelling and fatigue, aching, muscle cramps, itchiness, and others (Zhang & Melander, 2014). The economic impact of venous ulcers corresponds to the 2% of the total healthcare budget of all Western countries (Cilurzo et al, 2019).Treatments are aimed at removal or destruction of the abnormal vein segments. They can be invasive (e.g., venous stripping), more painful (e.g., endovenous thermal ablation) or non-invasive (e.g., ultrasound-guided sclerotherapy).…”

Section: Varicose Veinsmentioning

confidence: 99%

“…The main benefit of administering sclerosing foams lies in their capacity to mimic a piston that displaces intravenous blood, leading to a greater contact surface area with venous endothelium, reduced mixing with blood and subsequent deactivation, and reduced staining of the leg due to trapped blood in the collapsed vessel (Carugo et al, 2015). A recent study attempted to create polidocanol‐liposome nanoconstructs to further stabilize the resulting foam while minimizing interaction of the surfactant with plasma proteins (Cilurzo et al, 2019).…”

Section: Foam Sclerotherapymentioning

confidence: 99%

Foam‐in‐vein: A review of rheological properties and characterization methods for optimization of sclerosing foams

et al. 2020

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Varicose veins are chronic venous defects that affect >20% of the population in developed countries. Among potential treatments, sclerotherapy is one of the most commonly used. It involves endovenous injection of a surfactant solution (or foam) in varicose veins, inducing damage to the endothelial layer and subsequent vessel sclerosis. Treatments have proven to be effective in the short-term, however recurrence is reported at rates of up to 64% 5-year post-treatment. Thus, once diagnosed with varicosities there is a high probability of a permanently reduced quality of life. Recently, foam sclerotherapy has become increasingly popular over its liquid counterpart, since foams can treat larger and longer varicosities more effectively, they can be imaged using ultrasound, and require lower amounts of sclerosing agent. In order to minimize recurrence rates however, an investigation of current treatment methods should lead to more effective and long-lasting effects. The literature is populated with studies aimed at characterizing the fundamental physics of aqueous foams; nevertheless, there is a significant need for appropriate product development platforms. Despite successfully capturing the microstructural evolution of aqueous foams, the complexity of current models renders them inadequate for pharmaceutical development. This review article will focus on the physics of foams and the attempts at optimizing them for sclerotherapy. This takes the form of a discussion of the most recent numerical and experimental models, as well as an overview of clinically relevant parameters. This holistic approach could contribute to better foam characterization methods that patients may eventually derive long term benefit from.

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“…In addition, liposomal formulation of these drug can improve their pharmacokinetic properties, with higher drug accumulation in tumor and target delivery (Paolino et al, 2014;Licciardi et al, 2016). Liposome nanoparticles (LNP) are the most regularly examined nanocarrier due to their high drug loading capability, biocompatibility, self-assembling ability, and a wide range of biophysical and physicochemical properties that can be couturier to control their pharmacological features (Torchilin, 2006;Tsumoto et al, 2009;Jain et al, 2012;Chiara et al, 2017;Grillone et al, 2017;Cilurzo et al, 2019;Tan et al, 2019). On the basis of literature we try to fill out this low MPA bioavailability and efficacy gap through combination therapy of MPA and QC liposomes.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats

Patel

Thakur

Kushwah

et al. 2020

Front. Bioeng. Biotechnol.

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The present study explores the influence of mycophenolic acid (MPA) in combination therapy with quercetin (QC) (impeding MPA metabolic rate) delivered using the liposomal nanoparticles (LNPs). Mycophenolic acid liposome nanoparticles (MPA-LNPs) and quercetin liposome nanoparticles (QC-LNPs) were individually prepared and comprehensively characterized. The size of prepared MPA-LNPs and QC-LNPs were found to be 183 ± 13 and 157 ± 09.8, respectively. The in vitro studies revealed the higher cellular uptake and cytotoxicity of combined therapy (MPA-LNPs + QC-LNPs) compared to individual ones. Moreover pharmacokinetics studies in female SD-rat shown higher T 1/2 value (1.94 fold) of combined therapy compared to MPA. Furthermore, in vivo anticancer activity in combination of MPA-LNPs and QC-LNPs was also significantly higher related to other treatments groups. The combination therapy of liposomes revealed the new therapeutic approach for the treatment of breast cancer.

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Polydocanol foam stabilized by liposomes: Supramolecular nanoconstructs for sclerotherapy

Cited by 7 publications

References 35 publications

Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy

Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy

Foam‐in‐vein: A review of rheological properties and characterization methods for optimization of sclerosing foams

Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats

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