Polydopamine coated hypodermic needles as a microextraction device for the determination of tricyclic antidepressants in oral fluid by direct infusion MS/MS

Vejar-Vivar, Carmina; García-Valverde, María Teresa; Mardones, Claudia; Lucena, Rafael; Cárdenas, Soledad

doi:10.1039/d1ra02721b

Cited by 12 publications

(4 citation statements)

References 54 publications

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“…The use of sorptive-coated HNs has been recently reported to extract drugs from biosamples [ 24 , 43 ]. In these HNs, a polymer was coated in the inner wall of the needles.…”

Section: Resultsmentioning

confidence: 99%

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Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device

Millán-Santiago¹,

Lucena²,

Cárdenas³

2023

Journal of Pharmaceutical Analysis

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“…The use of sorptive-coated HNs has been recently reported to extract drugs from biosamples [ 24 , 43 ]. In these HNs, a polymer was coated in the inner wall of the needles.…”

Section: Resultsmentioning

confidence: 99%

“…Although 1 stroke presented the best reproducibility and 5 strokes provided the highest extraction efficiency, 3 strokes were selected as a compromise between precision and sensitivity. The results demonstrated a lower dependence of the sensitivity on the number of strokes compared to the inner coated needles [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device

Millán-Santiago¹,

Lucena²,

Cárdenas³

2023

Journal of Pharmaceutical Analysis

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“…For clarity, the procedure is described in detail in the supplementary information . However, for the analysis of real samples, direct oral fluid spitting is recommended because of the retention ability of the cellulosic cotton roll towards the target analytes [ 47 , 48 ]. Salivette® was used only during the optimization since it provides a large volume of samples more easily.…”

Section: Methodsmentioning

confidence: 99%

Pre-cleaned bare wooden toothpicks for the determination of drugs in oral fluid by mass spectrometry

2022

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This article deepens the potential of pre-cleaned bare wooden toothpicks (pb-WTs) for extracting drugs (antidepressants and acetaminophen) from oral fluid samples. The leaching of the intrinsic compounds from the wood matrix is identified as the main challenge for the final determination of the targets, even when a very selective instrumental technique, such as mass spectrometry, is employed. The pre-cleaning of the WTs is proposed for improving the analytical performance. The number of cleaning cycles depends on the injection mode (direct infusion or chromatography) into the mass spectrometer. The different variables affecting the extraction of selected antidepressant drugs were studied in detail, and the optimum procedure was validated using the two mentioned injection modes. The limits of detection were in the ranges 0.1–0.5 ng/mL and 0.1–0.3 ng/mL for direct infusion and liquid chromatography, respectively. The intra-day precision (expressed as relative standard deviation) was better than 12.1% and 8.6%, for direct infusion and liquid chromatography, respectively. Single-blind samples were used to study the applicability of the method. Finally, as a proof-of-concept, the potential of pb-WTs for in vivo sampling was outlined. Graphical abstract

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“…Na taj način objedinjeni su koraci uzorkovanja i ekstrakcije analita. Tehnika je do sad uspješno primijenjena za ekstrakciju tricikličkih antidepersiva iz sline, 18 doksorubicina iz plućnog tkiva 19 i valproične kiseline iz seruma 20 s iznimno visokim ekstrakcijskim učinkovitostima (preko 95 %). Premda je najveći nedostatak tehnike nemogućnost potpune automatizacije postupka pripreme uzoraka, ona je posljednjih godina našla svoju primjenu u bioanalitičkim istraživanjima (tablica 1).…”

Section: Osnovna Načela I Klasifikacija Tehnika Mikroekstrakcije Na č...unclassified

Mikroekstrakcija čvrstom fazom – inovativni pristup u bioanalitičkim istraživanjima

Mornar

Marinac-Anđić

Klarić

et al. 2022

Kemija U Industriji

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In last three decades, the solid-phase microextraction technology has brought significant progress in bioanalytical research due to the versatility of this fast and solvent-free approach to biological sample preparation. It has been widely used in combination with various analytical instrumentation, even if most of the work has been done by coupling the extraction technique with liquid or gas chromatography. This review focuses on the new developments and advances in solid-phase microextraction-based techniques. Furthermore, some interesting, new innovations that fail to go beyond academic research are also reported.

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Polydopamine coated hypodermic needles as a microextraction device for the determination of tricyclic antidepressants in oral fluid by direct infusion MS/MS

Abstract: Hypodermic needles coated with polydopamine for the extraction of antidepressants.

Cited by 12 publications

References 54 publications

Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device

Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device

Pre-cleaned bare wooden toothpicks for the determination of drugs in oral fluid by mass spectrometry

Mikroekstrakcija čvrstom fazom – inovativni pristup u bioanalitičkim istraživanjima

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