Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization

Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy

“…The excessive ROS production by inflammatory macrophages interferes with cell cycle progression and causes irreversible damage to periodontal tissues [ 13 , 34 ]. ROS also plays an essential role in maintaining the inflammatory phenotype of macrophages via activating NLRP3 inflammasome and promoting IL-1β induction [ 8 , 35 , 36 ]. Therefore, ROS clearance could be an important mechanism for Lipo-RSV for remodeling the immune microenvironment.…”

“…Meanwhile, a control group was set up using the healthy mice. After 2 weeks, the gingiva and upper jaw were harvested for histology analysis (H&E), methylene blue staining, and immunofluorescence[ 8 ]. At the experimental endpoint, the histology examination of the major organs was performed and no pathological changes were found (Additional file 1 : Figure S10).…”

“…Therefore, the traditional single antibacterial therapy may not be sufficient to solve such a complex problem of periodontitis [ 7 ]. Targeting the immune microenvironment could be a promising strategy for periodontitis [ 8 ].…”

“…It has been revealed that targeting macrophages is a potential therapeutic intervention for periodontitis [ 10 , 11 ]. For example, the repolarization of macrophages from M1-like inflammatory phenotype to M2-like anti-inflammatory phenotype can effectively ameliorate periodontitis [ 8 ].…”

Novel multifunctional dexamethasone carbon dots synthesized using the one-pot green method for anti-inflammatory, osteogenesis, and osteoimmunomodulatory in bone regeneration

“…23 In addition, it has been reported that elevated levels of reactive oxygen species (ROS) inhibit osteogenic differentiation, further leading to the failure of bone regeneration led by a bone graft. [24][25][26] The immune system additionally plays an important role in the process of bone tissue repair, macrophages can initiate an immune response to accelerate bone tissue healing. When bone defects occur, immune cells are involved in immune regulation at the injury site.…”