Polydopamine inner wall-coated hypodermic needle as microextraction device and electrospray emitter for the direct analysis of illicit drugs in oral fluid by ambient mass spectrometry

Vejar-Vivar, Carmina; Millán-Santiago, Jaime; Mardones, Claudia; Lucena, Rafael; Cárdenas, Soledad

doi:10.1016/j.talanta.2022.123693

Cited by 10 publications

(11 citation statements)

References 58 publications

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“…The voltage spray was set at 5 kV; the tube lens voltage was 130 V, and the capillary voltage and temperature were 35 V and 275 °C, respectively. The distance between the needle tip and the MS inlet was maintained at 10 mm, according to previous results . The m / z precursor → product ion transitions employed for quantification using 30 V as the collision energy were 315.3 → 193.1 and 318.3 → 196.1 for THC and THC- d 3 , respectively.…”

Section: Methodsmentioning

confidence: 99%

Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

López-Juan,

Millán-Santiago,

Benedé

et al. 2024

Anal. Chem.

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Direct coupling of sample preparation with mass spectrometry (MS) can speed up analysis, enabling faster decision-making. In such combinations, where the analysis time is mainly defined by the extraction procedure, magnetic dispersive solid-phase extraction emerges as a relevant technique because of its rapid workflow. The dispersion and retrieval of the magnetic sorbent are typically uncoupled stages, thus reducing the potential simplicity. Stir bar sorptive dispersive microextraction (SBSDME) is a novel technique that integrates both stages into a single device. Its miniaturization (mSBSDME) makes it more portable and compatible with low-availability samples. This article reports the direct combination of mSBSDME and MS using a needle-based electrospray ionization (NESI) emitter as the interface. This combination is applied to determine tetrahydrocannabinol in saliva samples, a relevant societal problem if the global consumption rates of cannabis are considered. The coupling requires only the transference of the magnet (containing the sorbent and the isolated analyte) from the mSBSDME to the hub of a hypodermic needle, where the online elution occurs. The application of 5 kV on the needle forms an electrospray on its tip, transferring the ionized analyte to the MS inlet. The excellent performance of mSBSDME-NESI-MS/MS relies on the sensitivity (limits of detection as low as 2.25 ng mL–1), the precision (relative standard deviation lower than 15%), and the accuracy (relative recoveries ranged from 87 to 127%) obtained. According to the results, the mSBSDME-NESI-MS/MS technique promises faster and more efficient chemical analysis in MS-based applications.

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Section: Methodsmentioning

confidence: 99%

Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

López-Juan,

Millán-Santiago,

Benedé

et al. 2024

Anal. Chem.

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“…used a hypodermic needle with a polydopamine (PDA)-coated inner wall as a microextraction and electrospray device to detect methamphetamine, methadone and cocaine in saliva. 40 The PDA film inside the technique for the rapid analysis of drugs in hair samples. 41 In this technique, a single hair is placed on a metal ceramic heater and a high voltage and solvent are added to the sample.…”

Section: Kim Et Al Used Sfpesi For the Rapid Detection Of Cocaine Met...mentioning

confidence: 99%

“…used a hypodermic needle with a polydopamine (PDA)‐coated inner wall as a microextraction and electrospray device to detect methamphetamine, methadone and cocaine in saliva. 40 The PDA film inside the needle allows for the rapid extraction of analytes at an alkaline pH, then eluted in a methanol‐based ESI solution for ionization. The study presents a cheap and disposable extraction/ionization probe with an overall analysis time of 3 min per sample.…”

Section: Applications Of Aimsmentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

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The development of ambient ionization mass spectrometry (AIMS) has transformed analytical science, providing the means of performing rapid analysis of samples in their native state, both in and out of the laboratory. The capacity to eliminate sample preparation and pre‐MS separation techniques, leading to true real‐time analysis, has led to AIMS naturally gaining a broad interest across the scientific community. Since the introduction of the first AIMS techniques in the mid‐2000s, the field has exploded with dozens of novel ion sources, an array of intriguing applications, and an evident growing interest across diverse areas of study. As the field continues to surge forward each year, ambient ionization techniques are increasingly becoming commonplace in laboratories around the world. This annual review provides an overview of AIMS techniques and applications throughout 2022, with a specific focus on some of the major fields of research, including forensic science, disease diagnostics, pharmaceuticals and food sciences. New techniques and methods are introduced, demonstrating the unwavering drive of the analytical community to further advance this exciting field and push the boundaries of what analytical chemistry can achieve.

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“…A very smart approach was recently proposed by Cárdenas and Lucena's research group [32]. The sorbent material is deposited in the inner walls of a needle and the sample is repeatedly aspirated and dispensed through the needle.…”

Section: Miniaturization Of Sorbent‐based Approachesmentioning

confidence: 99%

“…(B) Manifold used for the direct ambient mass spectrometry analysis using a needle as an extraction device. Reproduced with permission [25] and [32], respectively.…”

Section: Solid-phase Microextractionmentioning

confidence: 99%

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Azorín

Benedé

Chisvert

2023

J of Separation Science

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Miniaturization of the analytical process has been a widespread trend, and the sample preparation stage is not exempted from this downscaling. Since the introduction of microextraction techniques as miniaturization of classical extraction techniques, they have become one of the strengths in this field. However, some of the original approaches to these techniques did not fully cover all the current principles of Green Analytical Chemistry. For this reason, during the last years, much emphasis has been placed on reducing/eliminating toxic reagents, reducing the amount of the extraction phase, and searching for new greener, and more selective extractant materials. On the other hand, even though high accomplishments have been achieved, the same attention has not always been paid to reducing the amount of sample, which is essential when treating low‐availability samples such as biological samples, or in developing portable devices. In this review, we intend to give the readership an overview of the advances toward further miniaturization of microextraction techniques. Finally, a brief reflection is made on the terminology used, or that should, in our opinion, be used to term these new generation of miniaturized microextraction approaches. To this regard, the term, ‘ultramicroextraction’ is proposed to refer to those approaches beyond microextraction.

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Polydopamine inner wall-coated hypodermic needle as microextraction device and electrospray emitter for the direct analysis of illicit drugs in oral fluid by ambient mass spectrometry

Cited by 10 publications

References 58 publications

Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

Applications of ambient ionization mass spectrometry in 2022: An annual review

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

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