Polydopamine-modified collagen sponge scaffold as a novel dermal regeneration template with sustained release of platelet-rich plasma to accelerate skin repair: A one-step strategy

Zheng, Zijun; Li, Minxiong; Shi, Pengwei; Gao, Yanbin; Ma, Jun; Li, Yuchen; Huang, Lei; Yang, Zhangfeifan; Yang, Lei

doi:10.1016/j.bioactmat.2021.01.037

Cited by 68 publications

(33 citation statements)

References 82 publications

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“…Therefore, wound coverage is one of the most important issues in wound treatment. The ideal covering material should have the following characteristics: strong adhesion, promoting wound healing, and resisting infection [ 19 , 20 ]. With the development of bioengineering and materials science, the application of biomaterials has brought new breakthroughs in wound repair and functional reduction technology [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Curative Effect and Influencing Factors of Collagen Sponge Combined with Autologous Skin Graft in the Treatment of Deep Burn Patients

Cai

Jiang

Zang

2021

Evidence-Based Complementary and Alternative Medicine

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Burn is one of the common traumatic diseases in clinics. After deep burn, the complicated changes of the condition are caused by the burn wound, which ends with the repair of the wound. For patients with deep burns, whether the wound can be repaired as soon as possible is the key to the success of clinical treatment. For patients with deep burns, due to the lack of an autologous skin source, scar hyperplasia at donor site, skin graft repair at donor site, postoperative flap necrosis, and other problems in traditional surgical procedures, the method of improving function only by an autologous skin source has been unable to perform the later function reconstruction in patients with deep burns. In this study, collagen sponge combined with autologous skin graft was used to treat patients with deep burn, and the clinical efficacy of the patients was observed, and the related factors affecting the efficacy of the patients were analyzed. The results showed that collagen sponge combined with autologous skin graft was effective in the treatment of deep burn patients, and it was worth popularizing. Deep III-IV degree burns, wound infection, and hospital stay >3 months are all risk factors affecting the postoperative curative effect of patients. Therefore, in the clinical work, we should focus on patients with deep III-IV degree burns, perform surgery as soon as possible, and actively deal with wounds to prevent infection, which is beneficial to improve the curative effect.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Curative Effect and Influencing Factors of Collagen Sponge Combined with Autologous Skin Graft in the Treatment of Deep Burn Patients

Cai

Jiang

Zang

2021

Evidence-Based Complementary and Alternative Medicine

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“…In this case, little deformation of the hydrogel happened under external force. The pore size of hydrogel was also very important for angiogenesis [ [51] , [52] , [53] ]. Too small pore size could limit the migration and proliferation of the cells.…”

Section: Resultsmentioning

confidence: 99%

“…Synthetic polymer materials usually had good mechanical properties, but poor biocompatibility and safety, and they were lack of cell-induced activity. Compared with synthetic polymers, natural materials could provide more effectively support for cell viability, migration, adhesion, and differentiation, mimicking the mechanical and biochemical properties of the natural environment, and reducing the side effects of polymer degradation [ 33 , 34 ]. In this study, chitosan and alginate were used to construct the hydrogel, which were two attractive materials with excellent biocompatibility, biodegradability, and bioactivity for wound beds healing.…”

Section: Introductionmentioning

confidence: 99%

N-carboxymethyl chitosan/sodium alginate composite hydrogel loading plasmid DNA as a promising gene activated matrix for in-situ burn wound treatment

Wang

Sun

et al. 2022

Bioactive Materials

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“…PRP contains multiple growth factors, for instance, Platelet-Derived Growth Factor (PDGF) [ 315 , 321 ], TGF-β [ 287 , 292 ], Fibroblast Growth Factor (FGF) [ 292 , 323 ], Platelet-Derived Angiogenesis Factor (PDAF) [ 287 , 292 ], Vascular Endothelial Growth Factor (VEGF) [ 315 , 321 ], and Insulin-Like Growth Factor (IGF) [ 315 , 321 ]. PRP can be used alone, applied on a collagen sponge for sustained release [ 325 ] or encapsulated in hydrogel scaffolds, such as fibrin for craniofacial bone regeneration applications [ 305 , 306 ]. One of the advantages using PRP is to enhance cell migration and proliferation and angiogenesis [ 277 ].…”

Section: Protein-based Therapy: Current Approaches and Potential Therapymentioning

confidence: 99%

Craniofacial Bone Tissue Engineering: Current Approaches and Potential Therapy

Aghali

2021

Cells

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Craniofacial bone defects can result from various disorders, including congenital malformations, tumor resection, infection, severe trauma, and accidents. Successfully regenerating cranial defects is an integral step to restore craniofacial function. However, challenges managing and controlling new bone tissue formation remain. Current advances in tissue engineering and regenerative medicine use innovative techniques to address these challenges. The use of biomaterials, stromal cells, and growth factors have demonstrated promising outcomes in vitro and in vivo. Natural and synthetic bone grafts combined with Mesenchymal Stromal Cells (MSCs) and growth factors have shown encouraging results in regenerating critical-size cranial defects. One of prevalent growth factors is Bone Morphogenetic Protein-2 (BMP-2). BMP-2 is defined as a gold standard growth factor that enhances new bone formation in vitro and in vivo. Recently, emerging evidence suggested that Megakaryocytes (MKs), induced by Thrombopoietin (TPO), show an increase in osteoblast proliferation in vitro and bone mass in vivo. Furthermore, a co-culture study shows mature MKs enhance MSC survival rate while maintaining their phenotype. Therefore, MKs can provide an insight as a potential therapy offering a safe and effective approach to regenerating critical-size cranial defects.

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Polydopamine-modified collagen sponge scaffold as a novel dermal regeneration template with sustained release of platelet-rich plasma to accelerate skin repair: A one-step strategy

Cited by 68 publications

References 82 publications

Analysis of the Curative Effect and Influencing Factors of Collagen Sponge Combined with Autologous Skin Graft in the Treatment of Deep Burn Patients

Analysis of the Curative Effect and Influencing Factors of Collagen Sponge Combined with Autologous Skin Graft in the Treatment of Deep Burn Patients

N-carboxymethyl chitosan/sodium alginate composite hydrogel loading plasmid DNA as a promising gene activated matrix for in-situ burn wound treatment

Craniofacial Bone Tissue Engineering: Current Approaches and Potential Therapy

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