Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy

Abstract

Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver cisplatin via interaction between cisplatin and catechol groups on PDA-NPs. Polyethylene glycol (PEG) was introduced through Michael addition reaction to improve the stability of PDA-NPs in physiological condition. A remarkable synergistic therapeutic effect has been achieved compared with respective single treatments. This work suggests that the PDA-based nanoplatform can be a universal scaffold for combined chemo- and photothermal therapy of cancer.

The employment of a conformal polydopamine thin layer reduces the cytotoxicity of silver nanoparticles

“…Cytotoxicity tests of PDOP NPs depicted that this NP system is highly biocompatible with Caco2 cells and the low cytotoxicity is a valuable indicator to explore them as a promising candidate for the conformal coating of toxic NPs. Similar results were detected in some reports in the literature (Zhang et al, 2012;Chen et al, 2014;Zhong et al, 2015;Tang et al, 2016;Li et al, 2017;Yu et al, 2017;Zhu and Su, 2017;Dong et al, 2018;Gu et al, 2018;Poinard et al, 2018). For example, Tang et al tested the cytotoxicity of PDOP NPs on the HepG2 cell line and analyzed this through the MTT assay (Tang et al, 2016).…”

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

“…Besides ROS-scavenging inorganic nanoparticles, organic nanoparticles with intrinsic antioxidant activities have been emerging as a potential platform for the treatment of numerous diseases associated with inflammatory disorders (Kim K. S. et al, 2015;Zhu and Su, 2017;Kwon et al, 2019). Several types of organic nanoparticles have shown higher antioxidative advantages over conventional antioxidants and radical scavengers, owing to their predominant properties in terms of pharmacokinetics, biodistribution, delivery efficiency, and robust scavenging capabilities of multiple radicals Ferreira et al, 2018;Ye et al, 2019;Zafar et al, 2019).…”

“…These melanin-like nanoparticles, often known as polydopamine (PDA) nanoparticles, contain a population of antioxidant groups, thereby exhibiting strong free radical-scavenging ability. PDA nanoparticles have been widely studied in recent years (Chu et al, 2016;Liu et al, 2017;Zhu and Su, 2017;Bao et al, 2018;Zhao et al, 2018;Sun et al, 2019). Cai et al designed a melanin-based antioxidant defense nanosystem for acute kidney injury (Sun et al, 2019).…”

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

“…With regard to biocompatibility and cytotoxicity, multifunctional PDA NPs with tailored properties have received considerable attention in combined therapies, e.g., chemotherapy (CT) with photothermal therapy (PTT), gene delivery with PTT, or codelivery of various therapeutic molecules by a single system emerging as a new paradigm in nanomedicine. For example, a photosensitizer drug chlorin e6 (Ce6) and CT agent cisplatin‐loaded PDA NPs for combined photodynamic and chemo‐photothermal (PT) therapies have been reported . Similarly, the coloading of a Ce6 (photosensitizer) and curcumin (radiosensitizer) in PDA NPs was demonstrated for combined radio‐phtodynamic therapy, and thermo‐triggered and pH‐responsive poly(allylamine)‐citraconic anhydride‐coated doxorubicin (Dox)‐loaded PDA NPs have been investigated for PT–CT for prostate cancer .…”

“…For example, a photosensitizer drug chlorin e6 (Ce6) and CT agent cisplatinloaded PDA NPs for combined photodynamic and chemophotothermal (PT) therapies have been reported. [16,17] Similarly, the coloading of a Ce6 (photosensitizer) and curcumin (radiosensitizer) in PDA NPs was demonstrated for combined radiophtodynamic therapy, and thermo-triggered and pH-responsive poly(allylamine)-citraconic anhydride-coated doxorubicin (Dox)loaded PDA NPs have been investigated for PT-CT for prostate cancer. [18,19] In a very recent report, the arginine-glycineaspartic (RGD) peptide-decorated PDA NPs with improved PT effects via an additional modification of beclin 1 onto PDA NPs were reported.…”