Polydopamine/polyethyleneimine complex adhered to micrometer-sized magnetic carbon fibers for high-efficiency hemoperfusion

Abstract

Carbon-based nanomaterials have recently attracted tremendous attention in adsorption, separation and biological fields. However, such modification is not always straightforward when the surface is not chemically reactive. Given this reason, most carbon materials modification processes employ reactive linkers or coupling agents, which are complicated and time-consuming. Herein, we report on a dopamine-polyethyleneimine (PEI) coating strategy to fabricate micrometer-sized magnetic carbon fiber (MSMCF)-based extracorporeal blood-cleansing sorbent for hemoperfusion. Results showed that the dopamine/PEI-coated MSMCF had a twisted fiber shape with a size range of 80-120 μm in diameter and porous structure with a specific surface area of 146 m g. Adsorption behavior of dopamine/PEI-modified MSMCF was examined by using bilirubin as a toxin model compound. Equilibrium data were well fitted to the Langmuir isotherm model with a maximal adsorption capacity of 335.1 mg g at ambient temperature. The as-obtained material had relatively high bilirubin adsorption selectivity against albumin at a normal albumin concentration. In particular, the dopamine/PEI-coated MSMCF has excellent adsorption capacity and hemocompatibility compared to the MSMCF decorated only by dopamine or PEI. Therefore, this work may pave the way for enhancing the property of the extracorporeal blood-cleansing sorbent during hemoperfusion.

Multifunctional underwater superoleophobic cellulose-based composite aerogel with oil/water separation, dye adsorption, and antibacterial activities

“…5b) contains three peaks, which can be ascribed to the nitrogen atoms in the forms of quaternary nitrogen (N–Q at 400.87 eV, N–(C)3), CN (401.92 eV), and N–H (404.18 eV). 40,41 The XPS spectra confirmed the formation of a PDA/PEI co-deposited coating on the CE/QCE composite aerogel surface.…”

Design of Carrageenan-Based Heparin-Mimetic Gel Beads as Self-Anticoagulant Hemoperfusion Adsorbents

“…The injection of heparin during hemoperfusion increases the cost of treatment, and the patients also have the risk of bleeding and other side effects. 16 Thus, the adsorbents composed of natural polymer and synthetic polymer with excellent biocompatibility and satisfactory adsorption capacity are highly desired for hemoperfusion.…”

“…Traditional adsorbents with good mechanical strengths or enough adsorption capacities, such as activated carbon and synthetic resins, have been widely used for clinical hemoperfusion, but these adsorbents show undesired hemocompatibility. The injection of heparin during hemoperfusion increases the cost of treatment, and the patients also have the risk of bleeding and other side effects . Thus, the adsorbents composed of natural polymer and synthetic polymer with excellent biocompatibility and satisfactory adsorption capacity are highly desired for hemoperfusion.…”