Polyelectrolyte–Ion Complexes as Stimuli‐Responsive Systems for Controlled Drug Delivery

Herrera, Santiago E.; Agazzi, Maximiliano L.; Cortez, M. Lorena; Marmisollé, Waldemar A.; Tagliazucchi, Mario; Azzaroni, Omar

doi:10.1002/9783527834044.ch27

Cited by 3 publications

(1 citation statement)

References 170 publications

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“…Due to this property, polyamine can serve as a building block for the construction of nanoparticles that are stabilized exclusively by soft interactions like electrostatics. An example is the formation of nano-sized complex coacervates by the interaction between polyamines and multivalent salts like citrate, phosphates and polyphosphates 7, 8 . Poly(allylamine) hydrochloride (PAH) is one of the most frequently explored polyamines since its composition can be accurately determined and possesses only one type of amine: primary amines.…”

Section: Introductionmentioning

confidence: 99%

Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic adjuvant for vaccine development

Rizzo,

Sanches,

Chavero

et al. 2024

Preprint

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Nanotechnology plays a crucial role in vaccine development and provides the opportunity to design functional nanoparticles (Np) of different compositions, sizes, charges and surface properties for biomedical applications. The present study aims to evaluate a complex coacervate-like Np composed of poly(allylamine hydrochloride) (PAH) and tripolyphosphate (Tpp) as a safe vehicle and adjuvant for systemic vaccines. We investigated the activation of different antigen-presenting cells (APCs) with Np-PAH and its adjuvanticity in Balbc/c and different KO mice that were intraperitoneally immunized with Np-OVA.We found that Np-PAH increased the expression of CD86 and MHCII and promoted the production and secretion of interleukin-1β (IL-1β) and IL-18 through the inflammasome NLRP3 when macrophages and dendritic cells were co-incubated with LPS and Np-PAH. We evidenced an unconventional IL-1β release through the autophagosome pathway. The inhibition of autophagy with 3-methyladenine reduced the LPS/Np-PAH-induced IL-1β secretion. Additionally, our findings showed that the systemic administration of mice with Np-OVA triggered a significant induction of serum OVA-specific IgG and IgG2a, an increased secretion of IFN-γ by spleen cells, and high frequencies of LT CD4+IFN-γ+and LT CD8+IFN-γ+. In conclusion, our findings show that PAH-based Np promoted the inflammasome activation of innate cells with Th1-dependent adjuvant properties, making them valuable for formulating of novel preventive or therapeutic vaccines for infectious and non-infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic adjuvant for vaccine development

Rizzo,

Sanches,

Chavero

et al. 2024

Preprint

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Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications

Lim,

Blocher McTigue

2024

ACS Biomater. Sci. Eng.

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Complex coacervates, formed through electrostatic interactions between oppositely charged polymers, present a versatile platform for drug delivery, providing rapid assembly, selective encapsulation, and responsiveness to environmental stimuli. The architecture and properties of coacervates can be tuned by controlling structural and environmental design factors, which significantly impact the stability and delivery efficiency of the drugs. While environmental design factors such as salt, pH, and temperature play a crucial role in coacervate formation, structural design factors such as polymer concentration, polymer structure, mixing ratio, and chain length serve as the core framework that shapes coacervate architecture. These elements modulate the phase behavior and material properties of coacervates, allowing for a highly tunable system. In this review, we primarily analyze how these structural design factors contribute to the formation of diverse coacervate architecture, ranging from bulk coacervates to polyion complex micelles, vesicles, and cross-linked gels, though environmental design factors are considered. We then examine the effectiveness of these architectures in enhancing the delivery and efficacy of drugs across various administration routes, such as noninvasive (e.g., oral and transdermal) and invasive delivery. This review aims to provide foundational insights into the design of advanced drug delivery systems by examining how the origin and chemical structure of polymers influence coacervate architecture, which in turn defines their material properties. We then explore how the architecture can be tailored to optimize drug delivery for specific administration routes. This approach leverages the intrinsic properties derived from the coacervate architecture to enable targeted, controlled, and efficient drug release, ultimately enhancing therapeutic outcomes in precision medicine.

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Recent progress and application of the tetrahedral framework nucleic acid materials on drug delivery

Li,

Yan,

Shi

et al. 2023

Expert Opinion on Drug Delivery

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Polyelectrolyte–Ion Complexes as Stimuli‐Responsive Systems for Controlled Drug Delivery

Cited by 3 publications

References 170 publications

Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic adjuvant for vaccine development

Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic adjuvant for vaccine development

Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications

Recent progress and application of the tetrahedral framework nucleic acid materials on drug delivery

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