Polyester-based photocrosslinkable bioadhesives for wound closure and tissue regeneration support

Santos, Marta; Cernadas, Teresa; Martins, P.; Miguel, Sónia P.; Correia, Ilídio J.; Alves, Patrícia; Ferreira, Paula

doi:10.1016/j.reactfunctpolym.2020.104798

Cited by 14 publications

(7 citation statements)

References 45 publications

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“…The acryloyl and methacryloyl groups were introduced into the polymer side chain by the reaction of PHEMA with ICEA and ICEM, respectively ( Scheme ). [ 52–55 ] The reaction was monitored by a change in the IR spectrum. During the reaction, the intensity of the peak due to the N═C═O group at 2278 cm −1 gradually decreased, but the reaction proceeded slowly.…”

Section: Resultsmentioning

confidence: 99%

RAFT Polymerization of 2‐(tert‐Butoxycarbonyloxy)Ethyl Methacrylate and Transformation to Functional Polymers via Deprotection and the Subsequent Polymer Reactions

Jing

Osada

Kojima

et al. 2021

Macro Chemistry & Physics

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Reversible addition–fragmentation chain transfer (RAFT) polymerization of 2‐(tert‐butoxycarbonyloxy)ethyl methacrylate (BHEMA) is carried out using 4‐cyano‐4‐((dodecylsulfanylthiocarbonyl)sulfanyl)pentanoic acid as the RAFT agent. The polymers with a controlled molecular weight and polydispersity are produced when a large amount of the RAFT agent is used. The RAFT polymerization of isobutyl methacrylate is also carried out using poly(2‐(tert‐butoxycarbonyloxy)ethyl methacrylate) (PBHEMA) as the macro‐RAFT agent in order to synthesize diblock copolymers with a narrow molecular weight distribution. It is revealed that the control of the polymerization of BHEMA is achieved under limited polymerization conditions. Then, the acid‐catalyzed deprotection of tert‐butoxycarbonyloxy groups of PBHEMA is performed in the presence of trifluoroacetic acid at room temperature to obtain polymers with a hydroxy group in the side chain. The hydroxy‐containing polymers are further reacted with 2‐isocyanatoethyl acrylate and methacrylate to synthesize precursor polymers used for a thermally curing system.

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Section: Resultsmentioning

confidence: 99%

RAFT Polymerization of 2‐(tert‐Butoxycarbonyloxy)Ethyl Methacrylate and Transformation to Functional Polymers via Deprotection and the Subsequent Polymer Reactions

Jing

Osada

Kojima

et al. 2021

Macro Chemistry & Physics

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“…Photocrosslinking by UV or visible light has been extensively explored in the biomedical eld. 24,25,40 In this study, we modied PLA functional groups with L-lactide and PETA via one-pot ringopening polymerization. NMR and HMBC spectroscopy conrmed that photocrosslinked, low-molecular-weight PLA-PETA polymers with a network structure are obtainable via onestep synthesis.…”

Section: Discussionmentioning

confidence: 99%

One-pot synthesis of liquid photocrosslinkable poly(l-lactide) with terminal triacrylate

Rwei

Shu

2023

RSC Adv.

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“…In order to better tailor the end material properties, copolymerization is often a common strategy. For example, a bioadhesive based on PCL functionalized with a low-viscosity, isocyanate-functional unsaturated acrylic ester [ 144 ] or 2-isocyanatoethyl acrylate (AOI) [ 145 ] that was manufactured into flexible transparent films with an interesting set of biomedical applications, more important for surgical adhesives, have been proposed. There are few similar UV-curable approaches that produce a tissue adhesive that can be applied quickly.…”

Section: Surgical Implants (Suture Materials Tissue Adhesives Surgica...mentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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Polyester-based photocrosslinkable bioadhesives for wound closure and tissue regeneration support

Cited by 14 publications

References 45 publications

RAFT Polymerization of 2‐(tert‐Butoxycarbonyloxy)Ethyl Methacrylate and Transformation to Functional Polymers via Deprotection and the Subsequent Polymer Reactions

RAFT Polymerization of 2‐(tert‐Butoxycarbonyloxy)Ethyl Methacrylate and Transformation to Functional Polymers via Deprotection and the Subsequent Polymer Reactions

One-pot synthesis of liquid photocrosslinkable poly(l-lactide) with terminal triacrylate

Special Features of Polyester-Based Materials for Medical Applications

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