Polyester fibers can be rendered calcium phosphate‐binding by surface functionalization with bisphosphonate groups

Polini, Alessandro; Petre, Daniela G.; Iafisco, Michele; Schickert, Sónia de Lacerda; Tampieri, Anna; Beucken, Jeroen van den; Leeuwenburgh, Sander C.G.

doi:10.1002/jbm.a.36077

Cited by 13 publications

(23 citation statements)

References 24 publications

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“…A smaller number of studies is related to the surface functionalization of other polyesters, such as polylactide [36,37,38] and poly(lactide- co -caprolactone) [19,39,40,41]. Moreover, in the case of PLLA meshes, aminolysis is frequently used as a method of fiber fragmentation [42,43,44,45,46]. The aim of our paper is to explain the different efficiency of the aminolysis at the same processing conditions for various aliphatic polyesters in the form of nanofibers and films.…”

Section: Introductionmentioning

confidence: 99%

Aminolysis of Various Aliphatic Polyesters in a Form of Nanofibers and Films

Jeznach

Kołbuk

2019

Polymers

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Surface functionalization of polymer scaffolds is a method used to improve interactions of materials with cells. A frequently used method for polyesters is aminolysis reaction, which introduces free amine groups on the surface. In this study, nanofibrous scaffolds and films of three different polyesters–polycaprolactone (PCL), poly(lactide-co-caprolactone) (PLCL), and poly(l-lactide) (PLLA) were subjected to this type of surface modification under the same conditions. Efficiency of aminolysis was evaluated on the basis of ninhydrin tests and ATR–FTIR spectroscopy. Also, impact of this treatment on the mechanical properties, crystallinity, and wettability of polyesters was compared and discussed from the perspective of aminolysis efficiency. It was shown that aminolysis is less efficient in the case of nanofibers, particularly for PCL nanofibers. Our hypothesis based on the fundamentals of classical high speed spinning process is that the lower efficiency of aminolysis in the case of nanofibers is associated with the radial distribution of crystallinity of electrospun fiber with more crystalline skin, strongly inhibiting the reaction. Moreover, the water contact angle results demonstrate that the effect of free amino groups on wettability is very different depending on the type and the form of polymer. The results of this study can help to understand fundamentals of aminolysis-based surface modification.

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Section: Introductionmentioning

confidence: 99%

Aminolysis of Various Aliphatic Polyesters in a Form of Nanofibers and Films

Jeznach

Kołbuk

2019

Polymers

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“…Finally, frictional sliding operates mainly at the interface between the fiber and the matrix and plays an important role in the effective stress transfer between the two constituents so that more energy is dissipated and less fractures occur. 63…”

Section: Results and Discussionmentioning

confidence: 99%

Thermoresponsive Brushes Facilitate Effective Reinforcement of Calcium Phosphate Cements

Petre

Nadar

et al. 2019

ACS Appl. Mater. Interfaces

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Calcium phosphate ceramics are frequently applied to stimulate regeneration of bone in view of their excellent biological compatibility with bone tissue. Unfortunately, these bioceramics are also highly brittle. To improve their toughness, fibers can be incorporated as the reinforcing component for the calcium phosphate cements. Herein, we functionalize the surface of poly(vinyl alcohol) fibers with thermoresponsive poly( N -isopropylacrylamide) brushes of tunable thickness to improve simultaneously fiber dispersion and fiber–matrix affinity. These brushes shift from hydrophilic to hydrophobic behavior at temperatures above their lower critical solution temperature of 32 °C. This dual thermoresponsive shift favors fiber dispersion throughout the hydrophilic calcium phosphate cements (at 21 °C) and toughens these cements when reaching their hydrophobic state (at 37 °C). The reinforcement efficacy of these surface-modified fibers was almost double at 37 versus 21 °C, which confirms the strong potential of thermoresponsive fibers for reinforcement of calcium phosphate cements.

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“…2d, the presence of the P 2p signals at 134 eV further demonstrated that bisphosphonate groups were successfully introduced into GelMA. Thus, the FTIR, 1 H NMR, 31 P NMR and XPS data demonstrated that alendronate was successfully grafted onto GelMA.…”

Section: Characterization Of Gelma and Gelma-alnmentioning

confidence: 90%

“…27,28 Furthermore, BP groups strongly and reversibly bind calcium ions 29,30 and can also bind to hydroxyapatite, calcium phosphate and other calcium crystals. 31,32 BP groups were shown to have a high affinity for bone minerals, which leads to their selective uptake by bone. 33 Although the activity [34][35][36][37][38][39] and osteogenesis [40][41][42][43][44][45] of cells encapsulated in 3D GelMA hydrogels have been widely studied, fewer studies have focused on the osteogenesis of cells cultured in 3D BP-functionalized hydrogels.…”

Section: Introductionmentioning

confidence: 99%