Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations

Janićijević, Željko; Radovanović, Filip

doi:10.1016/j.polymer.2018.05.065

Cited by 11 publications

(6 citation statements)

References 31 publications

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“…Hydrophilic PAA-rich aggregates remain attached to the hydrophobic PLGA support due to the residual common chains. Such chains result from incomplete polymer/polymer demixing during phase separation as was also the case with the porous hydrophobic polyethersulfone matrix and PAA in our previous study (Janićijević and Radovanović, 2018).…”

Section: Sem Characterizationsupporting

confidence: 61%

“…Composite materials comprising a biocompatible hydrophobic polymer matrix and a crosslinked hydrogel capable of ion exchange are interesting candidates for innovative drug reservoirs. Such materials can be used for efficient storage and controlled passive or active release https://doi.org/10.1016/j.radphyschem.2019.108466 Received 11 February 2019; Received in revised form 17 July 2019; Accepted 25 August 2019 of cationic drugs, as demonstrated by our previous studies (Janićijević et al, 2019;Janićijević and Radovanović, 2018).…”

Section: Introductionmentioning

confidence: 90%

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Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties

Janićijević

Vujčić

Veljović

et al. 2020

Radiation Physics and Chemistry

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Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs.Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission.Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.

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Section: Sem Characterizationsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 90%

Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties

Janićijević

Vujčić

Veljović

et al. 2020

Radiation Physics and Chemistry

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“…In our previous work, we synthesized the poly(ether sulfone)/PAA composite hydrogel membrane reservoirs for transdermal delivery of cationic drug formulations by sequential application of photoirradiation and immersion precipitation . As we show here, this innovative synthesis method can be modified and adapted for the fabrication of implantable drug reservoirs.…”

Section: Introductionmentioning

confidence: 99%

Poly(DL‐Lactide‐co‐ε‐Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs

Janićijević

Ninkov

Kataranovski

et al. 2018

Macromolecular Bioscience

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Poly(DL‐lactide‐co‐ε‐caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy‐attenuated total reflection (FTIR‐ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion‐exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion‐controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days.

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“…Previous investigations have indicated that the polymeric vehicles (e.g., polyvinyl alcohol cryogel [ 71 ], polyethersulfone/polyacrylic acid composite hydrogel membrane [ 72 ], polyethylene oxide/pentaerythritol triacrylate/multi-walled carbon nanotubes composites [ 73 ], copolymer (PVA-co-PE) nanofiber membrane [ 74 ], and gelatin-polyacrylamide hydrogel [ 75 ]) have been commonly utilized in TDD systems. However, there are some potential problems/concerns that may arise when using the polymeric vehicles for drug delivery systems.…”

Section: Resultsmentioning

confidence: 99%

Application of Amyloid-Based Hybrid Membranes in Drug Delivery

et al. 2023

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The properties of amyloid fibrils, e.g., unique structural characteristics and superior biocompatibility, make them a promising vehicle for drug delivery. Here, carboxymethyl cellulose (CMC) and whey protein isolate amyloid fibril (WPI-AF) were used to synthesize amyloid-based hybrid membranes as vehicles for the delivery of cationic and hydrophobic drugs (e.g., methylene blue (MB) and riboflavin (RF)). The CMC/WPI-AF membranes were synthesized via chemical crosslinking coupled with phase inversion. The zeta potential and scanning electron microscopy results revealed a negative charge and a pleated surface microstructure with a high content of WPI-AF. FTIR analysis showed that the CMC and WPI-AF were cross-linked via glutaraldehyde and the interacting forces between membrane and MB or RF was found to be electrostatic interaction and hydrogen bonding, respectively. Next, the in vitro drug release from membranes was monitored using UV-vis spectrophotometry. Additionally, two empirical models were used to analyze the drug release data and relevant rate constant and parameters were determined accordingly. Moreover, our results indicated that in vitro drug release rates depended on the drug–matrix interactions and transport mechanism, which could be controlled by altering the WPI-AF content in membrane. This research provides an excellent example of utilizing two-dimensional amyloid-based materials for drug delivery.

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Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations

Cited by 11 publications

References 31 publications

Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties

Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties

Poly(DL‐Lactide‐co‐ε‐Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs

Application of Amyloid-Based Hybrid Membranes in Drug Delivery

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