2023
DOI: 10.1093/bjsopen/zrad028
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Polyethylene glycol-coated haemostatic patch for prevention of clinically relevant postoperative pancreatic fistula after pancreatoduodenectomy: randomized clinical trial

Abstract: Background The potential of haemostatic patches to reduce the rate of postoperative pancreatic fistula remains unclear. The aim of this trial was to evaluate the impact of a polyethylene glycol-coated haemostatic patch on the incidence of clinically relevant postoperative pancreatic fistula after pancreatoduodenectomy. Methods In this randomized, single-centre, clinical trial, patients undergoing pancreatoduodenectomy were ra… Show more

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Cited by 4 publications
(12 citation statements)
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“…Out of 613 studies identified during the systematic literature search, 18 RCTs were included in the analysis 1 , 23–39 . Reasons for exclusion were wrong study type, wrong intervention, wrong organ investigated, or different field of investigation; two studies were excluded due to an inappropriate control group 40 , 41 and four studies were excluded due to duplication.…”
Section: Resultsmentioning
confidence: 99%
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“…Out of 613 studies identified during the systematic literature search, 18 RCTs were included in the analysis 1 , 23–39 . Reasons for exclusion were wrong study type, wrong intervention, wrong organ investigated, or different field of investigation; two studies were excluded due to an inappropriate control group 40 , 41 and four studies were excluded due to duplication.…”
Section: Resultsmentioning
confidence: 99%
“…In DP, the stump was covered. A total of 13 RCTs used an artificial coverage technique 23–35 , 4 RCTs applied autologous material 1 , 36–38 , and 1 RCT used a combination of the two 39 . A total of 11 studies used fibrin-based materials, such as patches 24 , 27 , 30–32 and fibrin glue 25 , 26 , 33–35 , 39 .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Various materials have been reported to possess favorable characteristics in bleeding management. A variety of hemostatic materials are commercially available, including zeolite powder (ZLP) [ 1 ], silica [ 2 ], montmorillonite [ 2 ], kaolin [ 3 ], oxidized cellulose [ 4 ], collagen [ 5 ], gelatin [ 6 , 7 ], chitosan [ 8 , 9 ], silk fibroin [ 10 ], calcium alginate [ 8 ], fibrin [ 11 ], starch [ 12 ], peptides [ 13 ], polyethylene glycol [ 14 ], cyanoacrylate [ 15 ], and so on. Although these materials are hemostatic, they also have several limitations, including being expensive, having limited hemostatic or antibacterial effects, and being poorly biodegradable.…”
Section: Introductionmentioning
confidence: 99%
“…Taking the morbidity of a clinically relevant fistula into account, prophylactic measurements and treatment options have become a hot topic in recent years. In pancreatoduodenectomy, fibrin sealants or omental wrapping did not achieve consistent results regarding the incidence of POPF [ 5 , 6 , 7 ]. In distal pancreatectomy, different stump closure methods (stapler vs. hand-sewn), reinforcement of the resection margin with an absorbable fibrin sealant or a teres ligament patch and minimally invasive techniques such as a laparoscopic or robotic-assisted approach did not show a significant reduction [ 6 , 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%