Polyethylene particles stimulate monocyte chemotactic and activating factor production in synovial mononuclear cells in vivo:An immunohistochemical study in rabbits

Frøkjær, Jens Brøndum; Lind, Martin; Overgaard, Søren; Søballe, Kjeld; Bünger, Cody

doi:10.3109/17453679508995549

Cited by 36 publications

(16 citation statements)

References 19 publications

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“…Ishiguro et al 42 reported increased expression of MIP-1␣, MCP-1 and interleukin-8 (IL-8) in periprosthetic granulomatous tissue when compared with fibrous scar tissue. 42 Frokjar et al 43 showed induction of MCP-1 in synovial mononuclear cells and IL-8 in endothelial cells by the injection of polyethylene particles into rabbit knees. In our study, expression of RANTES was not observed in the monocyte/macrophage cultures with any particle concentration tested, but was stimulated by lipopolysaccharide.…”

Section: Discussionmentioning

confidence: 99%

Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles

Nakashima

Sun

Trindade

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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Particulate wear debris is associated with periprosthetic inflammation and loosening in total joint arthroplasty. We tested the effects of titanium alloy (Ti-alloy) and PMMA particles on monocyte/macrophage expression of the C-C chemokines, monocyte chemoattractant protein-1 (MCP-1), monocyte inflammatory protein-1 alpha (MIP-1␣), and regulated upon activation normal T expressed and secreted protein (RANTES). Periprosthetic granulomatous tissue was analysed for expression of macrophage chemokines by immunohistochemistry. Chemokine expression in human monocytes/macrophages exposed to Ti-alloy and PMMA particles in vitro was determined by RT-PCR, ELISA and monocyte migration.We observed MCP-1 and MIP-1␣ expression in all tissue samples from failed arthroplasties. Ti-alloy and PMMA particles increased expression of MCP-1 and MIP-1␣ in macrophages in vitro in a dose-and time-dependent manner whereas RANTES was not detected. mRNA signal levels for MCP-1 and MIP-1␣ were also observed in cells after exposure to particles. Monocyte migration was stimulated by culture medium collected from macrophages exposed to Ti-alloy and PMMA particles. Antibodies to MCP-1 and MIP-1␣ inhibited chemotactic activity of the culture medium samples.Release of C-C chemokines by macrophages in response to wear particles may contribute to chronic inflammation at the bone-implant interface in total joint arthroplasty.J Bone Joint Surg [Br] 1999;81-B:155-62.

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Section: Discussionmentioning

confidence: 99%

Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles

Nakashima

Sun

Trindade

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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“…However, as shown in Table, the amounts and sizes of particles have varied between the different studies (Howie et al 1988, Goodman 1994, Bobyn et al 1995, Dowd et al 1995, Frökjaer et al 1995, Goodman et al 1995, 1999, Kraemer et al 1995, Allen et al 1996, Aspenberg and Herbertsson 1996, Shanbhag et al 1997, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, 2001, Bechtold et al 2001, Bi et al 2001b, Sundfeldt et al 2002. The time of introduction of the particles and the design of the studies also varied greatly.…”

Section: Particle Diseasementioning

confidence: 99%

Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

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“…The continuous generation and presence of particulate wear debris in the periprosthetic tissue results in a chronic inflammatory state, i.e. macrophages and foreign body giant cells release a variety of cytokines after phagocytosis of different wear particles (3)(4)(5)(6). Hence, osteoblastic cells are suppressed, but osteoclastic cells show higher rates of proliferation leading to bone resorption.…”

Section: Introductionmentioning

confidence: 99%

The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles

Lochner

2011

Int J Mol Med

103

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Abstract. Aseptic loosening in total hip replacement is mainly caused by wear particles inducing inflammation and osteolysis. Wear can be a consequence of micromotions at the interface between implant and bone cement. Due to complex cellular interactions, different mediators (e.g. cytokines, proteinases) are released, which can promote osteolytic processes in the periprosthetic tissue followed by loosening of the implant. Furthermore, a reduced matrix synthesis and an induced apoptosis rate can be observed. The purpose of this study was to evaluate to what extent human primary osteoblasts exposed to wear particles are involved in the osteolysis. The viability, the secretion of collagen and collagenases and the variety of released cytokines after particle exposure was examined. Therefore, human osteoblasts were incubated with particles experimentally generated in the interface between hip stems with rough and smooth surface finishings as well as different material compositions (Ti-6Al-7Nb, Co-28Cr-6Mo and 316L) and bone cement mantle made of Palacos R containing zirconium oxide particles. Commercially pure titanium particles, titanium oxide, polymethylmethacrylate and particulate zirconium oxide were used as references. The results revealed distinct effects on the cytokine release of human osteoblasts towards particulate debris. Thereby, human osteoblasts released increased levels of interleukine (IL)-6 and IL-8 after treatment with metallic wear particles. The expression of VEGF was slightly induced by all particle entities at lower concentrations. Apoptotic rates were enhanced for osteoblasts exposed to all the tested particles. Furthermore, the de novo synthesis of type 1 collagen was reduced and the expression of the matrix metalloproteinase (MMP)-1 was considerably increased. However, wear particles of Co-28Cr-6Mo stems seemed to be more aggressive, whereas particles derived from stainless steel stems caused less adverse cellular reaction. Among the reference particles, which caused less altered reactions in the metabolism of osteoblasts in general, ZrO 2 can be assumed as the material with the smallest cell biological effects.

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Polyethylene particles stimulate monocyte chemotactic and activating factor production in synovial mononuclear cells in vivo:An immunohistochemical study in rabbits

Cited by 36 publications

References 19 publications

Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles

Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles

Aseptic loosening, not only a question of wear: A review of different theories

The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles

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