Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort

Laarhoven, Constance J.H.C.M. van; Setten, Jessica van; Herwaarden, Joost A. van; Pasterkamp, Gérard; Kleijn, Dominique P. V. de; Borst, Gert J. de; Laan, Sander W. van der

doi:10.1038/s41598-019-56230-3

Cited by 3 publications

(3 citation statements)

References 36 publications

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“… Duan et al 279 107 National Taiwan University Hospital To study the clinical manifestations and genetic characteristics of patients with TAA and dissection in Taiwan. Constance et al 281 415 Aneurysm-Express biobank To investigate the association between variation in genetic susceptibility to aneurysms and clinical phenotypes including aneurysm diameter, artery type, and aneurysm-related symptoms. Hosaka et al 282 862 National Clinical Database To study postoperative survival in patients with primary aortic or common iliac artery (CIA) aneurysms treated surgically.…”

Section: Clinical Cohort Studymentioning

confidence: 99%

“…Constance et al 281 415 Aneurysm-Express biobank To investigate the association between variation in genetic susceptibility to aneurysms and clinical phenotypes including aneurysm diameter, artery type, and aneurysm-related symptoms.…”

Section: University Hospital Of Colognementioning

confidence: 99%

“…Multigene NGS detection can not only help with early diagnosis but also suggest that diagnosed patients with aortic aneurysm may be at risk of dissection. Constance et al 281 selected 415 patients with aortic and peripheral aneurysms from the thesis-Express Biobank (a biobank consisting of surgically treated aortic and peripheral aneurysms) to study the association between genetic susceptibility to aneurysm variation and clinical phenotype. The mean age was 69 ± 8.1 years, the majority (85%) were male, and 349 (84%) had been treated.…”

Section: University Hospital Of Colognementioning

confidence: 99%

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The mechanism and therapy of aortic aneurysms

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Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally asymptomatic, it poses a significant threat to human life due to a high risk of rupture. Because of its strong concealment, it is difficult to diagnose the disease in the early stage. At present, there are no effective drugs for the treatment of aneurysms. Surgical intervention and endovascular treatment are the only therapies. Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm, the specific mechanisms remain unclear. Researchers are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and treatment. To better understand aortic aneurysm, this review elaborates on the discovery history of aortic aneurysm, main classification and clinical manifestations, related molecular mechanisms, clinical cohort studies and animal models, with the ultimate goal of providing insights into the treatment of this devastating disease. The underlying problem with aneurysm disease is weakening of the aortic wall, leading to progressive dilation. If not treated in time, the aortic aneurysm eventually ruptures. An aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic wall. The disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.

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