Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

Keliher, Edmund J.; Ye, Yuxiang; Wojtkiewicz, Gregory R.; Aguirre, Aaron D.; Tricot, Benoit; Senders, Max L.; Groenen, Hannah; Fay, François; Pérez-Medina, Carlos; Calcagno, Claudia; Carlucci, Giuseppe; Reiner, Thomas; Sun, Yuan; Courties, Gabriel; Iwamoto, Yoshiko; Kim, Hye-Yeong; Wang, Cuihua; Chen, John W.; Świrski, Filip K.; Wey, Hsiao‐Ying; Hooker, Jacob M.; Fayad, Zahi A.; Mulder, Willem J. M.; Weissleder, Ralph; Nahrendorf, Matthias

doi:10.1038/ncomms14064

Cited by 130 publications

(101 citation statements)

References 31 publications

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“…Experimental atherosclerosis has been quantified and characterized by several modalities, including ultrasound, 202 magnetic resonance imaging, 203,204 and positron emission tomography, sometimes in combination with computed tomography. 205,206 There have also been applications to experimental atherosclerosis using multimodality imaging such as positron emission tomography/magnetic resonance imaging. 207 Although noninvasive imaging holds promise, the resolution of these modalities provides a barrier to accurately determining lesion size in experimental atherosclerosis, particularly in mice.…”

Section: Noninvasive Imagingmentioning

confidence: 99%

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

Daugherty¹,

Tall²,

Daemen³

et al. 2017

ATVB

293

215

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Abstract-Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies. Recommendations include the following: (1) animal model selection, with commentary on the fidelity of mimicking facets of the human disease; (2) experimental design and its impact on the interpretation of data; and (3) standard methods to enhance accuracy of measurements and characterization of atherosclerotic lesions. (Arterioscler Thromb Vasc Biol. 2017;37:e131-e157.

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Section: Noninvasive Imagingmentioning

confidence: 99%

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

Daugherty¹,

Tall²,

Daemen³

et al. 2017

ATVB

293

215

View full text Add to dashboard Cite

show abstract

“…Intravital microscopy displayed extravasation and cellular uptake kinetics in CX3CR1 GFP reporter mice: 30 minutes after injection, Macroflor nanoparticles cleared from the blood stream and colocalized with CX3CR1 GFP macrophages in the myocardium (Fig. 3A, B) 32 . The optical time-lapse data on uptake by macrophages revealed that these nanoparticles were ingested by macrophages within a time frame that enables 1 PET imaging with the short isotope blood half-life of 18 F (~20 min).…”

Section: Immune - Cardiovascular System Interactionsmentioning

confidence: 99%

“…(F) In vivo MRI contrast to noise ratio (CNR) in infarct 90 min after IV myeloperoxidase -Gd injection. From Keliher et al 32 .…”

Section: Figurementioning

confidence: 99%

“…Radioisotopes solve the problem of agent detection in deep tissues where microscopic resolution is insufficient. Several studies have shown the exquisite match between optical and radionuclide labels in interrelated systems 32 .…”

Section: Multichannel Optical Imagingmentioning

confidence: 99%

“…Thus, these two imaging biomarkers could identify macrophage number (by Macroflor PET) and phenotype (by myeloperoxidase MRI) to uniquely differentiate between increasing and resolving inflammation (Fig. 3C–E; Supplemental movie 3) 32 .…”

Section: Immune - Cardiovascular System Interactionsmentioning

confidence: 99%

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Multiparametric Imaging of Organ System Interfaces

Vandoorne

Nahrendorf

2017

Circ: Cardiovascular Imaging

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Cardiovascular diseases are a consequence of genetic and environmental risk factors that together generate arterial wall and cardiac pathologies. Blood vessels connect multiple systems throughout the entire body and allow organs to interact via circulating messengers. These same interactions facilitate nervous and metabolic system influence on cardiovascular health. Multiparametric imaging offers the opportunity to study these interfacing systems’ distinct processes, to quantify their interactions and to explore how these contribute to cardiovascular disease. Noninvasive multiparametric imaging techniques are emerging tools that can further our understanding of this complex and dynamic interplay. PET/MRI and multichannel optical imaging are particularly promising because they can simultaneously sample multiple biomarkers. Preclinical multiparametric diagnostics could help discover clinically relevant biomarker combinations pivotal for understanding cardiovascular disease. Interfacing systems important to cardiovascular disease include the immune, nervous and hematopoietic systems. These systems connect with ‘classical’ cardiovascular organs, like the heart and vasculature, and with the brain. The dynamic interplay between these systems and organs enables processes such as hemostasis, inflammation, angiogenesis, matrix remodeling, metabolism and fibrosis. As the opportunities provided by imaging expand, mapping interconnected systems will help us decipher the complexity of cardiovascular disease and monitor novel therapeutic strategies.

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Understanding the In Vivo Fate of Advanced Materials by Imaging

Garlin

et al. 2020

Adv Funct Materials

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Engineered materials are ubiquitous in biomedical applications ranging from systemic drug delivery systems to orthopedic implants, and their actions unfold across multiple time‐ and length‐scales. The efficacy and safety of biologics, nanomaterials, and macroscopic implants are all dictated by the same general principles of pharmacology as applied to small molecule drugs, comprising how the body affects materials (pharmacokinetics, PK) and conversely how materials affect the body (pharmacodynamics, PD). Imaging technologies play an increasingly insightful role in monitoring both of these processes, often simultaneously: translational macroscopic imaging modalities such as magnetic resonance imaging and positron emission tomography/computed tomography offer whole‐body quantitation of biodistribution and structural or molecular response, while ex vivo approaches and optical imaging via in vivo (intravital) microscopy reveal behaviors at subcellular resolution. In this review, the authors survey developments in imaging the in situ behavior of systemically and locally administered materials, with a particular focus on using microscopy to understand transport, target engagement, and downstream host responses at a single‐cell level. The themes of microenvironmental influence, controlled drug release, on‐target molecular action, and immune response, especially as mediated by macrophages and other myeloid cells, are examined. Finally, the future directions of how new imaging technologies may propel efficient clinical translation of next‐generation therapeutics and medical devices are proposed.

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Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

Cited by 130 publications

References 31 publications

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

Multiparametric Imaging of Organ System Interfaces

Understanding the In Vivo Fate of Advanced Materials by Imaging

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