Polygodial, a sesquiterpene isolated from Drimys brasiliensis (Winteraceae), triggers glucocorticoid-like effects on pancreatic β-cells

Barrosa, Kaidu H.; Mecchi, Murilo C.; Rando, Daniela; Ferreira, Ari J. S.; Sartorelli, Patrı́cia; Valle, Maíra Mello Rezende; Bordin, Silvana; Caperuto, Luciana C.; Lago, João Henrique G.; Lellis‐Santos, Camilo

doi:10.1016/j.cbi.2016.09.013

Cited by 5 publications

(6 citation statements)

References 37 publications

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“…brasiliensis on β ‐cell survival. Biological response in pancreatic β ‐cell was triggered by the polygodial via the glucocorticoids pathway which includes the involvement of AMPK activation and in vitro survival of pancreatic β ‐cells (Barrosa et al, 2016). Some medicinal plants contain acyclic monoterpene alcohol called geraniol which was also found to have antidiabetic activity.…”

Section: Natural Products Having Antidiabetic Effect Via Targeting β‐mentioning

confidence: 99%

“…Pancreatic β-cell model (INS 1E) was used to test the efficacy of D. brasiliensis on β-cell survival. Biological response in pancreatic β-cell was triggered by the polygodial via the glucocorticoids pathway which includes the involvement of AMPK activation and in vitro survival of pancreatic β-cells(Barrosa et al, 2016). Some medicinal plants contain acyclic monoterpene alcohol called geraniol which was also found to have antidiabetic activity.Wistar albino rats were orally administered with 100-400 mg/kg geraniol dissolved in 2.5 ml/kg of corn oil and an aqueous solution of 5 mg/kg glyclazide.…”

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confidence: 99%

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Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreaticβ‐cells and restoring their dysfunction

Semwal

Kumar

Aswal

et al. 2020

Phytotherapy Research

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Diabetes mellitus is a growing public health concern and an increasing interest has been raised to search for new compounds with therapeutic effects on β-cells. There are chronic insulin resistance and loss of β-cell mass in the case of type-2 diabetes which covers about 90% of total diabetic patients. This work aims to critically review the protective and regenerative effects of various antidiabetic natural products on pancreatic β-cells. A thorough literature survey was conducted on the natural molecules and extracts having a protective, regenerative, and repairing effect on β-cells. The primary source of the literature was online scientific databases such as PubMed, Scopus, and Google Scholar. Besides, selected relevant textbooks were also consulted. Various natural molecules including berberine, curcumin, mangiferin, stevioside and capsaicin, and extracts obtained from the plants like Capsicum annum, Gymnema sylvestre, Stevia rebaudiana and Nymphaea stellate, were found to produce regenerative and anti-apoptosis effects on β-cells. These natural products were also found to increase insulin secretion by stimulating β-cells. The present review concluded that a large number of molecules and extracts, abundantly found in nature, possess antidiabetic effect via targeting β-cells. Further research is warranted to use these agents as a drug against diabetes.

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Section: Natural Products Having Antidiabetic Effect Via Targeting β‐mentioning

confidence: 99%

mentioning

confidence: 99%

Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreaticβ‐cells and restoring their dysfunction

Semwal

Kumar

Aswal

et al. 2020

Phytotherapy Research

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show abstract

“…traditionally in the aforementioned regions without apparent ill effects (Wayman et al, 2010;Huq et al, 2014;Barrosa et al, 2016). Perhaps the toxicity of warburganal and polygodial is mitigated by other phytochemicals or the toxicity of these two compounds may be limited in vivo.…”

Section: Discussionmentioning

confidence: 99%

Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial

Liu

Kipanga

Hung

et al. 2018

International Journal for Parasitology

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“…The chemical nature of polygodial is sesquiterpene, a plant derived compound used for various health conditions such as thyroiditis, asthma, allergies, arthritis, and autoimmune diseases (Barrosa et al, 2016). Sesquiterpene lactones (SLs) compounds can induce apoptosis of cancer cell by decreasing the levels of intracellular reduced glutathione (GSH).…”

Section: 0 Discussionmentioning

confidence: 99%

Polygodial analog induces apoptosis in LNCaP prostate cancer cells

Dasari

Samy

Narvekar

et al. 2018

European Journal of Pharmacology

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Prostate cancer (PCa) is the second leading cause of death in American men. The chemotherapeutic treatment strategies are generally not effective and can lead to side effects. Hence, there is an urgent need to identify novel chemotherapeutic agents. The aim of this study was to synthesize and evaluate the therapeutic effects of a synthetic analog of polygodial (PG), a pungent constituent abundantly present in mountain pepper, water pepper and dorrigo pepper, on LNCaP PCa cell line and its anti-cancer mechanisms in a preclinical study. We evaluated the anti-cancer potential of the PG analog namely DRP-27 using various assays such as cell viability by MTT assay, anchorage independent growth by soft agar assay, reactive oxygen species generation by 2',7'-dichlorofluorescein probe-based fluorescence assay, and apoptosis by Annexin-V and TUNEL assays respectively. Western blot analysis was performed to identify the molecular mechanism of DRP-27-induced cell death. Our results showed that DRP-27 significantly inhibited LNCaP cell proliferation in a dose-dependent manner at 48 h treatment in vitro. In addition, DRP-27 potently inhibited anchorage-independent growth of these cells. Flow cytometry, Annexin-V and TUNEL assays confirmed that DRP-27 induces apoptosis in LNCaP cells. DRP-27 also induced the activation of intracellular reactive oxygen species. Western blot analysis revealed that DRP-27 downregulated the expression of survivin, while activating Bax and DNA damage marker pHAX in LNCaP cells. In conclusion, our study suggests that DRP-27 might be an effective anti-cancer agent for PCa.

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Polygodial, a sesquiterpene isolated from Drimys brasiliensis (Winteraceae), triggers glucocorticoid-like effects on pancreatic β-cells

Cited by 5 publications

References 37 publications

Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreaticβ‐cells and restoring their dysfunction

Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreaticβ‐cells and restoring their dysfunction

Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial

Polygodial analog induces apoptosis in LNCaP prostate cancer cells

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