Polyheksanid – sikkerhet og effekt som antiseptikum

Fjeld, Hilde; Lingaas, Egil

doi:10.4045/tidsskr.14.1041

Cited by 39 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike in prokaryotes, eukaryotic cells present greater compartmentalization and eject the biocide from the nucleus. Therefore, a greater Minimum Inhibitory Concentration (MIC) of PHMB is required for human eukaryotic cells than for the microorganisms’ prokaryotic cells; thus, human cells can withstand the concentrations of biocide required for decontamination [ 27 , 28 , 29 , 30 ].…”

Section: Biguanidesmentioning

confidence: 99%

“…Machuca et al [ 27 ] demonstrated that PHMB-betaine solution was active against Gram-negative and Gram-positive bacteria, including biofilms of Klebsiella pneumoniae ST-716, Acinetobacter baumannii and S. aureus , all of which are of clinical concern due to rising antimicrobial resistance. This broad spectrum of activity both Gram-positive and Gram-negative bacteria has led to the use of PHMB against Mycobacterium species, including Mycobacterium smegmatis at an MIC of 5 mg/L for example [ 29 ]. Ongoing research aims to determine the suitability of PHMB as an antiseptic in wound dressings; Hübner et al [ 30 ] found that the presence of organic matter such as cartilage may affect the efficacy of PHMB against E. coli and S. aureus .…”

Section: Biguanidesmentioning

confidence: 99%

“…For example, the activity P-COOH-PHMB and P-COOH-CS-PHMB increased by 43.14% and 17.37% when the contact time was increased from 5 to 10 min. Nevertheless, P-COOH-CS-PHMB was the most effective at both exposure times and was 29.35% more effective after 5 min of exposure compared to P-COOH-PHMB [ 29 ]. Indeed, another study by Renzoni et al (2017) [ 32 ] found that PHMB was effective at decolonization of chlorhexidine-resistant strains of S. aureus strains at low PHMB concentrations, demonstrating the utility of PHMB as an antiseptic.…”

Section: Biguanidesmentioning

confidence: 99%

See 2 more Smart Citations

Biocide Use in the Antimicrobial Era: A Review

2021

View full text Add to dashboard Cite

Biocides are widely used in healthcare and industry to control infections and microbial contamination. Ineffectual disinfection of surfaces and inappropriate use of biocides can result in the survival of microorganisms such as bacteria and viruses on inanimate surfaces, often contributing to the transmission of infectious agents. Biocidal disinfectants employ varying modes of action to kill microorganisms, ranging from oxidization to solubilizing lipids. This review considers the main biocides used within healthcare and industry environments and highlights their modes of action, efficacy and relevance to disinfection of pathogenic bacteria. This information is vital for rational use and development of biocides in an era where microorganisms are becoming resistant to chemical antimicrobial agents.

show abstract

Section: Biguanidesmentioning

confidence: 99%

Section: Biguanidesmentioning

confidence: 99%

Section: Biguanidesmentioning

confidence: 99%

See 1 more Smart Citation

Biocide Use in the Antimicrobial Era: A Review

2021

View full text Add to dashboard Cite

show abstract

“…PHMB is a small molecule, with a characteristic carbon tail adjacent to a biguanide complex. PHMB's chemical structure closely resembles that of chlorhexidine, the most commonly used disinfectant and antiseptic of the skin prior to surgical operations [26]. At physiological pH, PHMB is polycationic due to the monoprotonation of each biguanide residue [27].…”

Section: Introductionmentioning

confidence: 98%

Nylon-6/chitosan core/shell antimicrobial nanofibers for the prevention of mesh-associated surgical site infection

et al. 2020

View full text Add to dashboard Cite

The state-of-the-art hernia meshes, used in hospitals for hernia repair, are predominantly polymeric textile-based constructs that present high mechanical strength, but lack antimicrobial properties. Consequently, preventing bacterial colonization of implanted prosthetic meshes is of major clinical relevance for patients undergoing hernia repair. In this study, the co-axial electrospinning technique was investigated for the development of a novel mechanically stable structure incorporating dual drug release antimicrobial action. Core/shell structured nanofibers were developed, consisting of Nylon-6 in the core, to provide the appropriate mechanical stability, and Chitosan/Polyethylene oxide in the shell to provide bacteriostatic action. The core/shell structure consisted of a binary antimicrobial system incorporating 5-chloro-8-quinolinol in the chitosan shell, with the sustained release of Poly(hexanide) from the Nylon-6 core of the fibers. Homogeneous nanofibers with a "beads-in-fiber" architecture were observed by TEM, and validated by FTIR and XPS. The composite nanofibrous meshes significantly advance the stress-strain responses in comparison to the counterpart single-polymer electrospun meshes. The antimicrobial effectiveness was evaluated in vitro against two of the most commonly occurring pathogenic bacteria; S. aureus and P. aeruginosa, in surgical site infections. This study illustrates how the tailoring of core/shell nanofibers can be of interest for the development of active antimicrobial surfaces.

show abstract

“…Polyhexamethylene biguanide (PHMB) is a polymer with the biocidal activity which is widely used as a preservative and as a broad-spectrum antiseptic. It is used as an antiseptic in the medical field in wound therapy [16], on skin and mucosa [17], and in eye disinfection [18][19][20][21][22][23]. In dentistry, PHMB is currently commercially available in mouthrinses and oral gels at various percentages up to 2% w/w [24].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled PHMB Titanium Coating Enables Anti-Fusobacterium nucleatum Strategy

et al. 2021

View full text Add to dashboard Cite

Fusobacterium nucleatum (F. nucleatum) is a gram-negative obligate anaerobe bacterium that threatens human periodontal health. It can cause many oral diseases, including periodontitis, gingivitis and peri-implantitis, and even some diseases such as colorectal cancer are related to it. This paper aims to develop a novel and simple surface modification method for anti-Fusobacterium nucleatum on titanium, i.e., the material for implants. In this study, different concentrations (0.0–1.0%) of PHMB were dip-coated on the titanium surface. The surface properties were examined with the aid of Scanning electron microscopy, Energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, and the antibacterial property against F. nucleatum was investigated using colony-forming unit. It was found that the PHMB successfully formed a self-assembled coating on the titanium surface and the PHMB-coated titanium had a strong capability of inhibiting F. nucleatum. Even though differences were found among the several concentrations, PHMB exhibited promising results as a simple coating strategy for dental implants.

show abstract

Polyheksanid – sikkerhet og effekt som antiseptikum

Cited by 39 publications

References 30 publications

Biocide Use in the Antimicrobial Era: A Review

Biocide Use in the Antimicrobial Era: A Review

Nylon-6/chitosan core/shell antimicrobial nanofibers for the prevention of mesh-associated surgical site infection

Self-Assembled PHMB Titanium Coating Enables Anti-Fusobacterium nucleatum Strategy

Contact Info

Product

Resources

About