Polyherbal drug loaded starch nanoparticles as promising drug delivery system: Antimicrobial, antibiofilm and neuroprotective studies

Alginates derived from macroalgae have been widely used in a variety of applications due to their stability, biodegradability and biocompatibility. Alginate was extracted from Egyptian Sargassum latifolium thallus yielding 17.5% w/w. The chemical composition of S. latifolium is rich in total sugars (41.08%) and uronic acids (47.4%); while, proteins, lipids and sulfates contents are 4.61, 1.13 and 0.09%, respectively. NMR, FTIR and TGA analyses were also performed. Crystallinity index (0.334) indicates alginate semicrystalline nature. Sodium alginate hydrolysate was evaluated as Chlorella vulgaris growth promoter. The highest stimulation (0.7 g/L biomass) was achieved by using 0.3 g/L alginate hydrolysate supplementation. The highest total soluble proteins and total carbohydrates were 179.22 mg/g dry wt and 620.33 mg/g dry wt, respectively. The highest total phenolics content (27.697 mg/g dry wt.), guaiacol peroxidase activity (2.899 µmol min−1 g−1) were recorded also to 0.3 g/L alginate hydrolysate supplementation. Riboflavin-entrapped barium alginate-Arabic gum polymeric matrix (beads) was formulated to achieve 89.15% optimum drug entrapment efficiency (EE%). All formulations exhibited prolonged riboflavin release over 120 min in simulated gastric fluid, followed Higuchi model (R2 = 0.962–0.887) and Korsmeyer–Peppas model with Fickian release (n ranges from 0.204 to 0.3885).

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“…Encapsulation efficiency percent (EE %) was determined following the equation of Nallasamy et al . 99 . …”

Section: Methodsmentioning

confidence: 99%

Characterization of alginate extracted from Sargassum latifolium and its use in Chlorella vulgaris growth promotion and riboflavin drug delivery

Dalal

Hussein

El‐Naggar

et al. 2021

Sci Rep

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“…The antimicrobial activity of the prepared samples was investigated using the well‐diffusion method [ 34 ]. The gram‐positive ( S. aureus and S. pneumoniae ) and gram‐negative ( K. pneumoniae, S. typhi, and P. aeruginosa ) bacteria were grown in nutrient agar medium and incubated at 37°C for 24 h followed by frequent subculture to fresh medium and were used as test bacteria.…”

Section: Methodsmentioning

confidence: 99%

Antibiofilm and antimicrobial efficacy evaluation of polypyrrole nanotubes embedded in aminated gum acacia based nanocomposite

Dhananjayan

Karthika

Wilson

et al. 2021

IET Nanobiotechnology

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The sustainable development of natural polysaccharide‐based hybrid composites is highly important for the effective replacement of metal nanoparticles in diverse applications. Here, polypyrrole nanotubes (PPyNTs) were embedded on the surface of aminated gum acacia (AGA) to produce ecofriendly nanocomposites for biomedical applications. The morphology of a PPyNT‐enhanced AGA (PPyNT@AGA) hybrid nanocomposite was studied by scanning electron microscopy and transmission electron microscopy and their affirmed interactions were characterised by X‐ray diffraction, Raman, Fourier transform‐infrared and UV‐visible spectroscopy. Interestingly, the prepared PPyNT@AGA nanocomposite exhibited 90% biofilm inhibition against gram‐negative Pseudomonas aeruginosa, gram‐positive Streptococcus pneumoniae and fungal strain Candida albicans with promising antimicrobial performance. This study establishes the good inhibition of a PPyNT@AGA hybrid composite against various microorganisms. The stability of the nanocomposite coupled with antimicrobial activity enables an effective strategy for diagnosing and controlling pathogens.

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“…By encapsulation of tridoshic rasayana Triphala Churna in starch NPs of 282.9 nm fast drug release at physiological pH 7 was achieved, and the NPs exhibited superb free radical scavenging activity, acetylcholinesterase inhibitory activity and antibacterial activity against Salmonella typhi and Shigella dysenteriae as well as antibiofilm activity against ATCC MRSA 33591 [ 232 ]. After cleavage of the azomethine bond, the conjugate of sodium cefotaxime and potato starch containing 68 mol% of CHO groups enabled prolonged-release delivery of the antibiotic, achieving ~83% after 10 h in normal saline and >90%, after 6–10 h in Tris-HCl buffer, and it was able to maintain therapeutic levels of the antibiotic [ 233 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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Polyherbal drug loaded starch nanoparticles as promising drug delivery system: Antimicrobial, antibiofilm and neuroprotective studies

Cited by 57 publications

References 34 publications

Characterization of alginate extracted from Sargassum latifolium and its use in Chlorella vulgaris growth promotion and riboflavin drug delivery

Characterization of alginate extracted from Sargassum latifolium and its use in Chlorella vulgaris growth promotion and riboflavin drug delivery

Antibiofilm and antimicrobial efficacy evaluation of polypyrrole nanotubes embedded in aminated gum acacia based nanocomposite

Advances in Nanostructures for Antimicrobial Therapy

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