2023
DOI: 10.3389/fnut.2023.1217051
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Polyherbal formulation PL02 alleviates pain, inflammation, and subchondral bone deterioration in an osteoarthritis rodent model

Prabhat Upadhyay,
Diya Kalra,
Aishwarya Shrikant Nilakhe
et al.

Abstract: IntroductionOsteoarthritis (OA) is a debilitating disease with significant personal and socioeconomic burdens worldwide.MethodsTo address this, we developed a multitargeted formulation called PL02, which includes standardized extracts of Rosa canina L, Hippophae rhamnoides, and collagen peptide. We tested the pharmacological efficacy of PL02 in a rodent model of OA induced by Monosodium iodoacetate (MIA).ResultsOur results demonstrate that oral administration of PL02 has antioxidant effects by down-regulating … Show more

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