Polyhydroxyalkanoates and their advances for biomedical applications

Gregory, David A.; Taylor, Caroline S.; Fricker, Annabelle T. R.; Asare, Emmanuel; Tetali, S.S.V.; Haycock, John W.; Roy, Ipsita

doi:10.1016/j.molmed.2022.01.007

Cited by 60 publications

(40 citation statements)

References 80 publications

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“…PHA has gained great interest in the area of biological tissue healing and engineering because of its structural variety and excellent physicochemical properties. PHA has been employed in soft and hard tissue regeneration fields, which include nerve repair, regeneration of heart valves and organs, and vascular, bone and cartilage tissue engineering [ 11 , 33 ]. PHA scaffolds are also employed to transport cells to a specific site during insertion, wherein cells are initially seeded onto the PHA-based scaffolding prior to utilization.…”

Section: Biomedical Applications Of Phamentioning

confidence: 99%

“…Skin may regenerate on its own and, in rare situations, small skin injuries can cure themselves [ 11 , 90 ]. However, depending on the length and severity of the defect, the degree of microbial invasion, and the patient’s health, skin transplants and tissue engineered skin may be necessary in the event of severe defects, as well as material intervention.…”

Section: Biomedical Applications Of Phamentioning

confidence: 99%

“…PHA is regularly categorized into two categories: short chain length (scl-PHAs) with four to five carbons, such as poly(3-hydroxyvalerate), (PHV) and poly(3-hydroxybutyrate), (PHB) and medium chain length (mcl-PHAs) with six to thirteen carbons, including poly(3-hydroxyhexanoates), (PHHx), and poly(3-hydroxyoctanoates) (PHO) [ 11 , 12 ]. Mcl-PHAs and scl-PHAs may be categorized as homo-polymers (scl-PHAs and/or mcl-PHAs) or copolymers (a combination of various monomers of scl-PHA and/or mcl-PHA monomers) based on the change in the length of the side chain caused by the addition of carbon atoms [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Mcl-PHAs and scl-PHAs may be categorized as homo-polymers (scl-PHAs and/or mcl-PHAs) or copolymers (a combination of various monomers of scl-PHA and/or mcl-PHA monomers) based on the change in the length of the side chain caused by the addition of carbon atoms [ 13 ]. Due to its high melting point, low ductility, and high crystallinity, PHB is an example of a scl-PHA with outstanding biomaterial properties for hard tissue engineering [ 11 ]. In comparison, due to its elastomeric characteristics and low melting-point, mcl-PHA is an excellent scaffolding material for the majority of soft tissue engineering applications [ 11 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Due to its high melting point, low ductility, and high crystallinity, PHB is an example of a scl-PHA with outstanding biomaterial properties for hard tissue engineering [ 11 ]. In comparison, due to its elastomeric characteristics and low melting-point, mcl-PHA is an excellent scaffolding material for the majority of soft tissue engineering applications [ 11 , 14 ]. Covalently connected copolymers may be created by adjusting the substrate sources throughout the manufacturing process, which can affect the mechanical and thermal characteristics of the PHAs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering

et al. 2022

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Tissue engineering technology aids in the regeneration of new tissue to replace damaged or wounded tissue. Three-dimensional biodegradable and porous scaffolds are often utilized in this area to mimic the structure and function of the extracellular matrix. Scaffold material and design are significant areas of biomaterial research and the most favorable material for seeding of in vitro and in vivo cells. Polyhydroxyalkanoates (PHAs) are biopolyesters (thermoplastic) that are appropriate for this application due to their biodegradability, thermo-processability, enhanced biocompatibility, mechanical properties, non-toxicity, and environmental origin. Additionally, they offer enormous potential for modification through biological, chemical and physical alteration, including blending with various other materials. PHAs are produced by bacterial fermentation under nutrient-limiting circumstances and have been reported to offer new perspectives for devices in biological applications. The present review discusses PHAs in the applications of conventional medical devices, especially for soft tissue (sutures, wound dressings, cardiac patches and blood vessels) and hard tissue (bone and cartilage scaffolds) regeneration applications. The paper also addresses a recent advance highlighting the usage of PHAs in implantable devices, such as heart valves, stents, nerve guidance conduits and nanoparticles, including drug delivery. This review summarizes the in vivo and in vitro biodegradability of PHAs and conducts an overview of current scientific research and achievements in the development of PHAs in the biomedical sector. In the future, PHAs may replace synthetic plastics as the material of choice for medical researchers and practitioners.

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Section: Biomedical Applications Of Phamentioning

confidence: 99%

Section: Biomedical Applications Of Phamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering

et al. 2022

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Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications

Dobrzyńska‐Mizera,

Dodda,

Liu

et al. 2024

Adv Healthcare Materials

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Herein, the recent advances in the development of resorbable polymeric‐based biomaterials, their geometrical forms, resorption mechanisms, and their capabilities in various biomedical applications are critically reviewed. A comprehensive discussion of the engineering approaches for the fabrication of polymeric resorbable scaffolds for tissue engineering, drug delivery, surgical, cardiological, aesthetical, dental and cardiovascular applications, are also explained. Furthermore, to understand the internal structures of resorbable scaffolds, representative studies of their evaluation by medical imaging techniques, e.g., cardiac computer tomography, are succinctly highlighted. This approach provides crucial clinical insights which help to improve the materials’ suitable and viable characteristics for them to meet the highly restrictive medical requirements. Finally, the aspects of the legal regulations and the associated challenges in translating research into desirable clinical and marketable materials of polymeric‐based formulations, are presented.

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Application of biomaterials in cardiac tissue engineering: Current status and prospects

Zhang,

He,

et al. 2024

MedComm – Biomaterials and Applications

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Cardiovascular diseases have become one of the leading causes of death and illness worldwide, posing significant challenges to global health. Due to the limited regenerative capacity of the heart, conventional approaches to treating heart diseases have demonstrated limited effectiveness. Therefore, leveraging biomaterials and biotechnologies in cardiac tissue engineering has emerged as a promising therapeutic strategy. This review aims to summarize the various characteristics of biomaterials in cardiac tissue engineering and their significance in addressing heart diseases. We categorize biomaterials into natural, synthetic, and conductive types based on their sources and unique properties, focusing on their applications in cardiac tissue engineering. We then present current applications of biomaterials in cardiac tissue engineering, followed by a discussion of existing challenges such as long‐term material stability, biocompatibility, adverse reactions, and precise application methodologies. Additionally, we provide insights into potential strategies for overcoming these challenges, aiming to enhance the effectiveness and safety of biomaterials in cardiac tissue engineering applications. Finally, this review highlights the potential of emerging biomaterials and technologies, underscoring the critical role of interdisciplinary collaboration in driving innovation and progress in cardiac tissue engineering.

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Polyhydroxyalkanoates and their advances for biomedical applications

Cited by 60 publications

References 80 publications

Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering

Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering

Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications

Application of biomaterials in cardiac tissue engineering: Current status and prospects

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