Polyhydroxyalkanoates: the natural biopolyester for future medical innovations

Ren, Zi-Wei; Wang, Zeyu; Ding, Yanwen; Dao, Jin-Wei; Li, Hao-Ru; Xue, Ming; Yang, Xinyu; Zhou, Ziqi; Liu, Jiaxuan; Mi, Chen-Hui; Gao, Zhengxiang; Peng, Hua; Wei, Daixu

doi:10.1039/d3bm01043k

Cited by 12 publications

(2 citation statements)

References 386 publications

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“…3 b) also demonstrated consistent experimental results. Compared with widely studied biodegradable polymers in biomedical applications, such as polylactic acid (PLA) and polylactic acid-polyethylene glycol copolymer (PLGA), PHA exhibits higher biocompatibility, its surface properties and chemical structure help reduce adverse reactions of organisms to the material, making it more compatible with living tissues and organisms [ 72 , [82] , [83] , [84] , [85] ]. In addition, PHA as hydrophobic drug carriers for controlled release offer advantages due to their tunable properties, high biocompatibility, and biodegradability, providing an effective and sustainable solution for drug delivery.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Ding,

Li,

Zhang

et al. 2024

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Ding,

Li,

Zhang

et al. 2024

Bioactive Materials

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“…Polymers play an important role in preparing medical material and are widely used in the medical field [1][2][3][4][5][6][7]. Sometimes they are not fully suitable for the clinical applications as using for interventional materials and infecting by bacteria susceptibly, resulting in catheter-related bloodstream infections (CRBSI) [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Non-soluble antibacterial polyurethane based on cation mechanism and functionalized by chitosan and heparin azide

Li,

Zhang,

Liu

et al. 2024

Biomed. Mater.

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Nowadays, medical polyurethanes with favorable and durable antibacterial properties received more attention, because of avoiding repeated replacement of interventional materials and reducing patients’ pain. In this thesis, non-soluble antibacterial polyurethane (NAPU) based on cation antibacterial mechanism was prepared by photo-grafting chitosan azide and heparin azide into polyurethane (PU). –NH3 + of chitosan azide absorbed bacteria, inhibiting and breaking their mobility and structures. Heparin azide prevented cations from penetrating bacteria’s membranes and inhibited their growth. The results showed that chitosan azide and heparin azide were successfully grafted into PU. The highest antibacterial rate was 92.07%, cytotoxicity grade ranging from 0–1 (RGR standard) and water contact angle exhibiting 60°, attributing to cation antibacterial effect and –OH existing. Tensile strength was up to 23.91 MPa and was suitable for using as medical materials. NAPU with long-lasting coating both possessed antibacterial properties and persistence, which can solve the problem of medical catheters’ long-term using.

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Poly(Butylene Succinate) Copolyesters Modified with Linear‐Chain Diols toward Adjustable Thermal, Mechanical, and Biodegradable Properties

Wang,

Yu,

et al. 2024

Macro Chemistry & Physics

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The production and application of poly(butylene succinate) (PBS) still face challenges such as high production costs, insufficient toughness, and slow biodegradation. This study utilizes the ring‐opening condensation polymerization method to prepare PBS copolyesters using succinic anhydride (SAA) and 1,4‐butanediol (BDO) as raw materials, with 20 moL% different lengths of linear‐chain diols as third monomers (carbon numbers are 3, 5, 6, 8, 9,10, and 12). Both PBS and its copolyesters exhibit high weight average molecular weights (18.8 × 104–26.1 × 104 g moL−1), much higher than those obtained through the traditional conventional direct esterification method. Incorporating the third monomer reduces the glass transition temperature (Tg), crystallinity, and melting point (Tm) of the copolyesters. As the chain length of the third monomer increases, the copolyesters show improved toughness, with the elongation at break and notch impact strength of poly(butylene succinate‐ran‐dodecylene succinate) (P(BS‐ran‐DoS)) increasing from 374.1% and 5.6 KJ m−2 of PBS to 723.2% and 64.8 KJ m−2, respectively. The degradation rate of the copolyesters modified with short‐chain diols increases significantly, and as the chain length of the third monomer increases, the degradation rate of the copolyesters slows down. Therefore, the selection of the third monomer can be used to adjust the properties of the polymer.

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Polyhydroxyalkanoates: the natural biopolyester for future medical innovations

Abstract: Polyhydroxyalkanoates (PHAs) are a family of natural microbial biopolyesters with the same basic chemical structure and diverse side chain groups. Based on their excellent biodegradability, biocompatibility, thermoplastic properties and diversity,...

Cited by 12 publications

References 386 publications

Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Non-soluble antibacterial polyurethane based on cation mechanism and functionalized by chitosan and heparin azide

Poly(Butylene Succinate) Copolyesters Modified with Linear‐Chain Diols toward Adjustable Thermal, Mechanical, and Biodegradable Properties

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