Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

Liu, Hongju; Chen, Senhua; Liu, Weiyang; Liu, Yayue; Huang, Xishan; She, Zhigang

doi:10.3390/md14120217

Cited by 64 publications

(41 citation statements)

References 20 publications

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“…Microorganisms from the mangrove environment produce a multitude of novel and biologically-active natural products [2,3]. According to genomic studies, numerous microorganisms have far greater potential to produce specialized metabolites than was thought from classic bioactivity screens.…”

Section: Introductionmentioning

confidence: 99%

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

et al. 2017

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Two new sesquiterpenes, microsphaeropsisin B (1) and C (2), and two new de-O-methyllasiodiplodins, (3R, 7R)-7-hydroxy-de-O-methyllasiodiplodin (4) and (3R)-5-oxo-de-O-methyllasiodiplodin (5), together with one new natural product (6) and twelve known compounds (3, 7–17), were isolated from the co-cultivation of mangrove endophytic fungus Trichoderma sp. 307 and aquatic pathogenic bacterium Acinetobacter johnsonii B2. Their structures, including absolute configurations, were elucidated by extensive analysis of spectroscopic data, electronic circular dichroism, Mo2(AcO)4-induced circular dichroism, and comparison with reported data. All of the isolated compounds were tested for their α-glucosidase inhibitory activity and cytotoxicity. New compounds 4 and 5 exhibited potent α-glucosidase inhibitory activity with IC50 values of 25.8 and 54.6 µM, respectively, which were more potent than the positive control (acarbose, IC50 = 703.8 µM). The good results of the tested bioactivity allowed us to explore α-glucosidase inhibitors in lasiodiplodins.

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Section: Introductionmentioning

confidence: 99%

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

et al. 2017

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“…1α-isopropyl-4α,8-dimethylspiro dec-8-ene-3β,7αdiol (26) Trichoderma sp. Xy24 Xylocarpus granatum [15] 10.…”

Section: -Epichaetomugilin I (57)mentioning

confidence: 99%

“…The compounds were isolated from a variety of fungi and were found to exhibit ROS and NO inhibition effect. The compounds included xylarenones C, D, F and G (16)(17)(18)(19), periconianone A and B (20-21), glomeremophilane A, C and D (22)(23)(24), cyclonerodiol B (25), 1α-isopropyl-4α,8-dimethylspiro [4.5]dec-8-ene-2β,7α-diol (26), and pestaloporinate B (27) (▶ Fig. 3).…”

Section: Ai Sesquiterpenes and Sesquiterpenoidsmentioning

confidence: 99%

“…They were active against TNF-α and IL-6 in the LPS-induced human monocytic cell line (THP-1) (▶ Table 2). Ergoflavin (47) was found to be highly active showing IC 50 values of 1.9 µM and 1.2 µM against TNF-α and IL-6, respectively [26,30].…”

Section: Ai Xanthone and Xanthenesmentioning

confidence: 99%

“…Corynesidone A (103) was found to be significantly active against NO production, exhibiting an IC 50 value of 1.88 µM. Compound 1,8-dimethoxynaphthalene (102) showed an IC 50 value of 2.0 µM against the secretion of IL-6 (▶ Table 2) [9,11,16,18,20,21,24,26,27,29,31,34,44].…”

Section: Miscellaneous Compoundsmentioning

confidence: 99%

See 2 more Smart Citations

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

2020

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A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

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Chemistry and Bioactivities of Secondary Metabolites from the Genus Talaromyces

Lan

2020

Chemistry & Biodiversity

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Fungi have especially captured the interest and fascination of natural product chemists in that they produce a dizzying array of natural organic molecules with many unique functional groups and atom arrangements. In this review, we focus on the genus Talaromyces (Trichocomaceae) which has been a hot spot of natural product studies over the last three decades. This review summarized the discovery, structures, and bioactivities of various classes of 151 compounds isolated from both terrestrial and marine derived fungal strains of the genus Talaromyces reported from 1994 to 2019.

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Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

Cited by 64 publications

References 20 publications

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

Chemistry and Bioactivities of Secondary Metabolites from the Genus Talaromyces

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